Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2026/08/24 Journal Club (Dilina)

 

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Y. J. Lin†, A. Takahashi-Nakazato†, C. Tsutsumi†, T. Takahashi†, D. Mercier, H. Ashitomi, M. C. Chiang, M. Haberl, M. Uytiepo, A. Maximov, Y. Makino, T. And the car, R. Enoki, A. Hirano, C. Rope, S. Walking razor trick, N. Ohno, Y. Kubota, T. Sakurai, C. Z. Tanaka

Science. 393(6812):eaee7004. Published. August 13, 2026.

PMID: 42594194 DOI: 10.1126/science.aee7004

posted on 08/22/2026 11:43 AM

2026/07/27 JC (Ishikawa)

Oxytocin promotes socially triggered cataplexy
Carrie E Mahoney et al.,

Nature neuroscience. 2026 Jul 14. doi: 10.1038/s41593-026-02352-7. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

https://pubmed.ncbi.nlm.nih.gov/42449131/

posted on 07/27/2026 12:24 AM

2026/7/13 Journal Club (Suyama)

Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets

Herman Munguba ∙ Anisul Arefin ∙ Ryota Hasegawa ∙ Luca Posa ∙ Giovanna R. Romano ∙ Teja N. Peddada ∙ Alexander Donatelle ∙ Ashna Singh ∙ Vanessa A. Good time ∙ Akshara Vijay ∙ Prerana Vaddi ∙ Melanie Krist ∙ Daniel Shaver ∙ Shanjida Hoque ∙ Johannes Broichhagen ∙ Joseph M. Stujenska ∙ Francis S. Lee ∙ Evan O’Brien ∙ Joshua Levitz ∙ Conor Liston
Cell, Volume 189, Issue 9p2612-2632.e24April 30, 2026

posted on 07/12/2026 12:26 PM

2026.5.25. Journal Club (Takeo)

Excitatory synapses onto axonic spines jump-start action potentials and route information flow

Which, …, Shu et al., Nat Neurosci. 2026 May 15. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

PMID: 42141306 DOI: 10.1038/s41593-026-02282-4

posted on 05/22/2026 2:02 PM

Journal club 2026/03/15 (Ishikawa)

Neuron. 2026 Feb 17:

Juvenile-to-adult refinement of thalamic reticular circuits via LRRTM3 enables high-resolution sensory encoding

Lee et al.,
https://pubmed.ncbi.nlm.nih.gov/41709459/

posted on 03/15/2026 4:39 PM

Journal Club 2026/3/2 (Thomas)

I presented this recent paper on fast AMPAR dynamics at the synapse, and the effects on short term plasticity (STP)

Nowacka, Agata et al. “Synapse-specific and plasticity-regulated AMPA receptor mobility tunes synaptic integration.” Neuron., S0896-6273(25)00931-6. 4 Feb. 2026, doi:10.1016/j.neuron.2025.12.004

https://www.sciencedirect.com/science/article/pii/S0896627325009316

posted on 02/27/2026 12:45 PM

2026.2.9. Journal club (Takeo)

Vinh Nguyen, Nasturtium Big, Brandon M Stell

Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals

Nat Neurosci. 2026 Jan;29(1):136-146. doi: 10.1038/s41593-025-02126-7.

PMID: 41345279

posted on 02/06/2026 6:47 PM

2026/2/2 Journal Club (Suyama)

Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer’s disease

Yun Lei, Jayvon Nougaisse, Maryam Malek, Miskatul M. Mishu, Yu Bai, Dundee, Quansheng Du, Alexis M. Stranahan, Jacob C. Garza & Xin-Yun Lu
Molecular Psychiatry volume 30, pages 4720–4735 (2025)

posted on 02/01/2026 6:31 PM

2026/1/26 Journal Club (Oishi)

Geometric principles of dendritic integration of excitation and inhibition in cortical neurons

Soroush Darvish-Ghane, Pankaj Gaur, and Graham C. R. Ellis-Davies.

Science Advances Vol 12, Issue 3.

DOI: 10.1126/sciadv.adx2045

 

posted on 01/21/2026 10:01 AM

2026. 1. 19 Journal club (Arai)

Science. 2025 Dec 11;390(6778):eadn0623. doi: 10.1126/science.adn0623. Epub 2025 Dec 11.
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability
Vincent Robert et al.

PMID: 41166439

 

posted on 01/19/2026 9:21 AM

2026/1/5 Journal Club (Thomas)

I presented the paper “Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning”

https://www.nature.com/articles/s41593-025-02072-4

posted on 01/05/2026 10:10 AM

2025. 12. 22 Journal club (Arai)

Science. 2025 Oct 16;390(6770):eads7954. doi: 10.1126/science.ads7954. Epub 2025 Oct 16.
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
Chang-Lu Tao et al.

PMID: 41100620

posted on 12/22/2025 2:00 PM