■神経細胞のタンパク質NP2がシナプス後AMPA受容体（AMPAR）に結合するのを阻害するVHH抗体の開発 (J Biol Chem) 2025.11.25 Yokoo T, Nakado M, Matsuda K, Caaveiro JMM, Fernandez-Perez J, Yuzaki M, Tsumoto K. Development of a VHH that inhibits the binding of neuronal pentraxin 2 to a post-synaptic glutamate receptor, AMPAR. J Biol Chem. 2025 Nov 25:110975. doi: 10.1016/j.jbc.2025.110975. Epub ahead of print. PMID: 41308985. 脳では神経細胞同士が「シナプス」でつながり、exchanging information。This study、シナプス作りを助けるタンパク質NP2が、How it binds to the receptor (AMPAR) and works、Elucidated using a small antibody (VHH) that specifically binds to NP2。This antibody was found to be able to prevent the binding of NP2 and AMPAR.、Detection of NP2、Expected to be applied to the treatment of chronic itch。This is the dissertation of Mr. Yokoo, who joined the Yuzaki lab from the University of Tokyo Tsumoto lab and Nakakido lab as a JSPS Research Fellow PD.。

■Chemical probes that glow quickly and reversibly、It is now possible to repeatedly capture AMPA receptor movement during learning. (Sci Adv) 2025.6.1 Soga K, Fujiwara T, Nakagawa M, Shibata A, Adriel h, Yatsuzuka K, Kakegawa W, Yuzaki M, Hamachi I, Dear E, Kiyonaka S. Rapid and reversible fluorescent probe enables repeated snapshot imaging of AMPA receptors during synaptic plasticity. Sci Adv. 11:eadt6683, 2025. doi: 10.1126/sciadv.adt6683. PMID: 40479050. When we learn and remember、The connections (synapses) between the brain's nerve cells change。This change、The movement of molecules called AMPA receptors on the surface of neurons play an important role.。Until now、To observe the movement of these molecules in detail,、Methods have been used to manipulate genes to make receptors light.、There was a problem that genetic manipulation did not allow successful reproduction of the original function of neurons.。In this study、PFQX1(AF488)By using a chemical probe,、We showed that we can observe the movement of AMPA receptors on the surface of neurons without genetic manipulation。This chemical probe is quick、Moreover, it can repeatedly light up the receptors、It is possible to capture synaptic changes that occur during learning and memory like a "snapshot."。This is a wonderful job at Nagoya University's Seichu Research Institute, which was collaboratively researched at ERATO/CREST.。Kakegawa and Yuzuzaki helped out a little bit。