■Chemical probes that glow quickly and reversibly、It is now possible to repeatedly capture AMPA receptor movement during learning. (Sci Adv) 2025.6.1 Soga K, Fujiwara T, Nakagawa M, Shibata A, Adriel h, Yatsuzuka K, Kakegawa W, Yuzaki M, Hamachi I, Dear E, Kiyonaka S. Rapid and reversible fluorescent probe enables repeated snapshot imaging of AMPA receptors during synaptic plasticity. Sci Adv. 11:eadt6683, 2025. doi: 10.1126/sciadv.adt6683. PMID: 40479050. When we learn and remember、The connections (synapses) between the brain's nerve cells change。This change、The movement of molecules called AMPA receptors on the surface of neurons play an important role.。Until now、To observe the movement of these molecules in detail,、Methods have been used to manipulate genes to make receptors light.、There was a problem that genetic manipulation did not allow successful reproduction of the original function of neurons.。In this study、PFQX1(AF488)By using a chemical probe,、We showed that we can observe the movement of AMPA receptors on the surface of neurons without genetic manipulation。This chemical probe is quick、Moreover, it can repeatedly light up the receptors、It is possible to capture synaptic changes that occur during learning and memory like a "snapshot."。This is a wonderful job at Nagoya University's Seichu Research Institute, which was collaboratively researched at ERATO/CREST.。Kakegawa and Yuzuzaki helped out a little bit。