A paper by Kakegawa has been published in Journal of NeuroscienceIt became Accept to。Under the title "top N-terminal region of δ2 receptors rapidly induce cerebellar parallel fiber synapses in in vivo"、It is a joint research with Miyazaki Watanabe teacher of Hokkaido University。「It has been featured in "This Week in The Journal." "As was featured in this week's attention paper。

The last paper (J. Neurosci. 28:1460-1468, 2008)so、Delta 2 receptors controls the LTD signal transduction system via intracellular domain (C-terminal)、From that had been proposed to control the morphological synapse formation via a separate extracellular domain (N-terminal)。We found that it is actually induced synapse formation delta 2 receptor in just one day after when expressed in the cerebellum of the mature animal using a viral vector in this paper。We also see that the N-terminal domain is necessary and sufficient for this action。

03/29/2009 9:11 PM | What's New