Welcome to Yuzaki Lab
    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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We await the participation of motivated indivisuals。We will vigorously nurture young researchers who will lead the future of basic science.。
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Unique modification mechanism path through the P2-type purinergic receptors in the mouse retina (Eur. J. Neurosci. ) 2008.12.31
Kaneda, M., Ishii, T., Hosoya, T. Pathway-dependent modulation by P2-purinoceptors in the mouse retina. Eur. J. Neurosci., 28:128-136, 2008.

Delta-2 receptor and Cbln1 mechanisms of synaptic plasticity by two molecular forms with old and new (Invited review; Neuroscience) 2008.12.3
Yuzaki, M. New (but old) molecules regulating synapse integrity and plasticity: Cbln1 and the delta2 glutamate receptor. Neuroscience 162, 633-643, 2009.

AP-mysterious relationship between autophagy and 4 (Invited Addendum; Autophagy) 2008.7.3
Matsuda, S., Yuzaki, M. AP-4: Autophagy-four mislocalized proteins in axons. Autophagand 4:815-6, 2008.

Cbln1 can induce rapid formation of mature excitatory synapses in the cerebellum but also in vivo in vitro (J Neurosci) 2008.4.28
Ito-Ishida, A., Miura, E., Emi, K., Matsuda, K., Iijima, T., Kondo, T., Kohda, C. Watanabe, M., Yuzaki, M. Cbln1 Regulates Rapid Formation and Maintenance of Excitatory Synapses in Mature Cerebellar Purkinje Cells in vitro and in vivo. J. Neurosci. 28:5920-5930, 2008.

Sites of phosphorylation by protein kinase C-delta 2 receptor is not required to express LTD (Keio J Med)2008.4.12
Nakagami, R., Kohda, K., Kakegawa, W., Kondo, T., Kato, N., and Yuzaki, M. Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression. Keio J. Med., 57:105-110, 2008.

AP-4 controls the polarity of transport and autophagy to dendritic receptors AMPA (Neuron) 2008.2.8

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Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M., Yuzaki, M. Accumulation of AMPA Receptors in Autophagosomes in Neuronal Axons Lacking Adaptor Protein AP-4. Neuron. 57: 730-745, 2008.

New nerve-derived cytokines:Cbln and C1q family (invited review;CMLS) 2008.1.7
Yuzaki, M. Cbln and C1q family proteins―new transneuronal cytokines, Candll. Mol. Life Sci., 65: 1698-1705, 2008.

2 C-terminus of the delta receptor in the brain synapse formation is necessary but not involved in LTD induction in the brain (J Neurosci) 2008.1.1
Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M., Yuzaki, M. Differential Regulation of Synaptic Plasticity and Cerebellar Motor Learning by the C-terminal PDZ-Binding Motif of GluRdelta2. J. Neurosci. 28:1460-1468, 2008.