Welcome to Yuzaki Lab
    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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We await the participation of motivated indivisuals。We will vigorously nurture young researchers who will lead the future of basic science.。
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Be present in the axons in cerebellar development is important CAPS2 (PLoS One)2014.6.20
Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Oregon C, Ishizaki Y, Yuzaki M, Where M, Furuichi T. Axonal localization of Ca2 -dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum.PLoS One. 2014 June 12;9(6):e99524.

Given Mr. Fang、Furuichi is a joint research with teacher。Kakegawa lecturer was in charge of the electrical physiology。

Towards the standardization of the minimum necessary information of experimental spinal cord injury (J Neurotrauma)2014.6.10
Lemmon VP, Ferguson AR…,Yuzaki M, Zheng B, Zhou F, Zou Y. Minimum Information About a Spinal Cord Injury Experiment (MIASCI) – a proposed reporting standard for spinal cord injury experiments.J Neurotrauma. Epub.

Lemmon et al., Miami group is the paper on standardization of spinal cord injury experiments became the center (MIASCI)。

Abundantly expressed in specific synapses of the cerebellum and forebrain delta type 1 glutamate receptors (J Neurosci)2014.6.6
Konno K, Matsuda K, Nakamoto C, Uchigashima M, Miyazaki T, Yamasaki M, Sakimura K, Yuzaki M, Watanabe M. Enriched Expression of GluD1 in Higher Brain Regions and Its Involvement in Parallel Fiber-Interneuron Synapse Formation in the Cerebellum.J Neurosci. 34:7412-7424, 2014.

Delta type 1 glutamate receptor (GluD1) is、Delta receptor type 2 with (GluD2)、Not know function while belong to the glutamate receptor family、It has been treated as an orphan receptor。The GluD1 protein has been considered also a little present in the mature brain。However、Abnormalities GluD1 gene in human mental disorders are reported one after another in recent years、It can be seen that the phenotype, such as aggression increased and social deterioration even in GluD1 gene-deficient mice can be seen、Function of GluD1 has been attracting attention。In this paper,、By developing GluD1 specific antibody、Specifically GluD1 was the first time that the expression evident in various brain regions such as the brain, the limbic system, striatum, cerebellum also in the mature brain。In particular by GluD1 genetic defects in the cerebellum、Synapses between parallel fibers (granule cell axons) intervening neurons were found to decrease significantly。This paper is the result of joint research with Niigata cerebral Research, Sakimura Institute with a focus on School of Medicine Ken Watanabe Hokkaido。

Directly to the nerve cell reprogramming (Molecular Brain) skin fibroblasts marmoset2014.4.6

Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, Okano HJ, Sasaki E, Okano H. Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.Molecular Brain. Epub.

This paper that reprogramming skin fibroblasts of marmoset directly to the nerve cells。It is the thesis of Ken Okano Satoshi Shu, et al.。Koda, Associate Professor in the yuzu Saki Research、Ibata Assistant Professor gave a functional analysis as a nerve cell。

Role of Cbln1 in Purkinje cell synapse formation between (Neurosci Res)2014.3.7

Ito-Ishida A, Okabe S, Yuzaki M. The role of Cbln1 on Purkinje cell synapse formation. Neurosci Res. Epub.

Cbln1 parallel fibers released from granule cells (granule cell axons) - with strongly promotes the formation of a functional excitatory synapses between Purkinje cells、And indirectly suppress the formation and function of inhibitory synapses between intervening neural over Purkinje cells。This review is the commemorative paper of Ishida's our department-born was awarded the Japan Neuroscience Society of Young Scientist Award (currently the United States during the study)。

Is Cbln1 suppress the formation and function of inhibitory synapses of nerve-mediated over Purkinje cells between (Eur J Neurosci)2014.1.14

Ito-Ishida A, Kakegawa W, Kohda K, Okabe S, Yuzaki M. Cbln1 down-regulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells. Eur J Neurosci. Epub.

One of the formation and function of the excitatory synaptic and inhibitory synaptic input to the nerve cells is believed to have been controlled in conjunction with each other, but we do not know well the entity。Cerebellar parallel fibers and secretion in this paper、Is Cbln1 to strongly promote the formation of a functional excitatory synapses between Purkinje cell - parallel fibers、It has revealed that to suppress the formation and function of inhibitory synapses between intervening neural over Purkinje cells in the opposite。This study is the work centered on the Ishida's graduate student OB (currently the United States during the study)。