Welcome to Yuzaki Lab
    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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We await the participation of motivated indivisuals。We will vigorously nurture young researchers who will lead the future of basic science.。
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Voltage-gated sodium channel gene refractory epilepsy patients (αII gene SCN2A) novel mutation was found in (Neurology) 2009.12.31
Ogiwara I., Ito K., Sawaishi Y., Osaka H., Mazak E., Inoue I., Montal M., Hashikawa T., Shike T., Fujiwara T., Y. Inoue, Kaneda M., Yamakawa K. De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology,73:1046-1053, 2009.

Efficient way of differentiating Purkinje cells from mouse ES cells (J Neurosci Res) 2009.9.2
The Tao, Shimazaki T, Okada Y, Naka H, Kohda K, Yuzaki M, Mizusawa H, Okano H. Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells. J Neurosci Res 88:234-47,2010.

AP-AMPA receptors are transported to dendrites by four polar (invited review; Neurosci Res) 2009.5.29
Matsuda, S., Yuzak, M. Polarized Sorting of AMPA Receptors to the Somatodendritic Domain Is Regulated by Adaptor Protein AP-4. Neurosci. Res., 65:1-5, 2009

most N-terminal region of δ2 receptors are rapidly induced in the cerebellar parallel fiber synapses in vivo (J Neurosci) 2009.3.26
Kakegawa, W., Miyazaki, T., Kohda, K., Matsuda, K., Emi, K., Motohashi, J., Watanabe, M., Yuzaki, M. The N-terminal domain of GluD2 (GluRd2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo, J. Neurosci. 29:5738-5748, 2009

Cbln1 expressed by neuronal activity is suppressed - in the homeostatic control during development and maturation (J Neurosci) 2009.3.24
Iijima, T., Emi., K., Yuzaki, M. Activity-dependent repression of Cbln1 expression: mechanism for developmental and homeostatic regulation of synapses in the cerebellum. J. Neurosci.29:5425-5434、2009.

Glutamate receptor delta-receptors and NMDA receptor (Invited review; Handbook of Neurochem & Mol Neurobiol) 2009.1.8
Yuzaki, M. Glutamate Receptors: NMDA and Delta Receptors. In: Neural Signaling Mechanisms (Mikoshiba, C. and), Handbook of Neurochemistry and Molecular Neurobiology (Lajtha, A. ed-in-chief), , Springer, New York, 2009, in press.

Endogenous Cbln1 parallel fiber - Cbln3 and δ2 receptor is localized with Purkinje cells in the synaptic cleft (Eur J Neurosci) 2009.1.1
Miura, E., Matsuda, K., Morgan, J.I., Yuzaki, M., Watanabe, M. Cbln1 accumulates and colocalizes with Cbln3 and GluRδ2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum. Eur. J. Neurosci. 29:693–706, 2009.

Recombinant Cbln1 specifically bind to the postsynaptic parallel fiber Purkinje cell synapses over (Eur J Neurosci) 2009.1.1
Matsuda, K., Kondo, T., Iijima, T., Matsuda, S., Watanabe, M., Yuzaki, M. Cbln1 binds to specific postsynaptic sites at parallel fiber–Purkinje cell synapses in the cerebellum. Eur. J. Neurosci. 29:707-717, 2009.