Welcome to Yuzaki Lab
    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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We await the participation of motivated indivisuals。We will vigorously nurture young researchers who will lead the future of basic science.。
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P2X3 in the mouse retina, P2X5, immunohistochemical distribution of P2X6 purinergic receptor types (J. Mol. Histol.) 2007.12.31
Shigematsu Y., Shimoda Y., Kaneda M. Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.J. Mol. Histol., 38:369-371, 2007.

Voltage-dependent ion channels in mouse retina cholinergic amacrine cells (J. Neurophysiol.) 2007.12.31

Kaneda, M., Ito, K., Morishima, Y., Shigematsu, Y., and Shimoda, Y. Characterization of voltage-gated ionic channels in cholinergic amacrine cells in the mouse retina. J. Neurophysiol., 97:4225-4234, 2007.

Double-membrane structures accumulate in neurons and axon terminals lacking autophagy (Autophagy) 2007.9.5

Nishiyama,J., Miura, E., Mizushima, N., Watanabe, M., Yuzaki, M. Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy,3:591-6, 2007.

The LTD-inducing delta-2 receptors are not involved in channel function (J Physiol) 2007.8.13

Kakegawa,W., Kohda, K., Yuzaki, M. The delta2 “ionotropic” glutamate receptor functions as a non-ionotropic receptor to control cerebellar synaptic plasticity. J Physiol., 584:89-96, 2007.

Lurcher:Old and new cerebellar ataxia mouse (invited review; Brain Res) 2007.4.6

Bird, MW, Caston, J., Yuzaki, M., Mariani, J. The Lurcher mouse: fresh insights from an old mutant. Brain Res, 1140:4-18, 2007.

And delta receptors (co-author The Glutamate Receptors Paperback) 2007.4.6

Yuzaki, M. Delta receptors. In: The Glutamate Receptors. (Gereau, RW, and Swanson, G.T. eds), 2008, The Humana Press, New Jersey.

Delta 2 C-terminus of the receptor is essential for inducing LTD (Eur J Neurosci) 2007.4.6

Kohda, K., Kakegawa, W., Matsuda, S., Nakagami, R., Kakiya, N., Yuzaki, M. The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices. Eur. J. Neurosci., 25:1357-1362, 2007.

The new mutant receptors spontaneously ho15J Delta 2 (Brain Res) 2007.4.6

Motohashi, J., Kakegawa, W., Yuzaki, M. Ho15J―a new hotfoot allele in a hot spot in the gene encoding the delta2 glutamate receptor. Brain Res. 1140:153-160, 2007.

In rat models of PTSD is going on glucocorticoid receptor activation (Neurosci) 2007.4.6

Kohda K, Harada K, Kato K, Hoshino A, Motohashi J, Yamaji T, Morinobu S, Matsuoka N, Kato N. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: A putative post-traumatic stress disorder model. Neuroscience. 148:22-33, 2007.

Abnormal cerebellar development and function in mice lacking the CAPS2 involved in the secretion Neurotrophin (J Neurosc) 2007.3.3

Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh-Semba, R., Shutoh, F., Okamoto, T., Nakashima., H., Kimura, K., Tanaka, M., Sekine, Y., Itohara, S., Yuzaki, M., Nagao,S., Furuichi, T. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J. Neurosci., 27:2472-2482, 2007.

Ca2 -permeable receptor-inducing delta-2 is not involved in synapse formation and LTD (J Physiol) 2007.1.15

Kakegawa, W., Miyazaki, T., Hirai, H., Motohashi, J., Mishina, M., Watanabe, M., Yuzaki, M. Ca2 permeability of the channel pore is not essential for the delta2 glutamate receptor to regulate synaptic plasticity and motor coordination. J. Physiol. 579.3:729-735, 2007.

Analysis of synaptogenesis Cbln factor protein family (Eur J Neurosci) 2007.1.1

Iijima, I., Miura, E., Matsuda, K., Kamekawa, Y., Watanabe, M., Yuzaki, M. Characterization of a transneuronal cytokine family Cbln―Regulation of secretion by heteromeric assembly. Eur. J. Neurosci., 25:1049-1057, 2007.