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    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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We await the participation of motivated indivisuals。We will vigorously nurture young researchers who will lead the future of basic science.。
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Top News

Kainate receptors act as synaptogenic molecules

kainate-type glutamate receptor (KAR)A paper on the function of synapse formation is available online.became。KAR is、through ionotropic and metabotropic effects.、Involved in various neuropsychiatric and neurological disorders。However、Compared to AMPA-type and NMDA-type glutamate receptors,、The biological properties of KARs remain unclear in many ways。In this research、K.A.R.、Completely separate from ion channels and metabotropic effects、We revealed that it acts as a synapse organizer that creates synapses themselves.。In joint research with the Juan Lerma laboratory in Spain.、Associate Professor Kakegawa and Ana Paternain are first authors。For Press releaseClick here. 。

posted on 07/10/2024 9:40 AM

LGI1 is secreted from axons during neural activity

A paper co-authored with Jaime de Juan-Sanz of the Sorbonne University in France was published.Published in Cell Reportsit was done。LGI1, like Cbln1, is a synaptogenic molecule that belongs to the class of "extracellular scaffold proteins."。On this occasion、Like Cbln1, LGI1 is also secreted in response to neural activity and promotes synapse formation.、It was also found that it suppresses glutamate release.。Interestingly, Cbln1 is tetanus toxin (TeNT)(VAMP1-3 independent)、Secreted by Syntaxin-4 and SNAP49-dependent SNAREs。In contrast, LGI1 secretion was partially inhibited by TeNT.、Because it does not depend on SNAP29、found to be released by separate SNARE complexes。Yuzaki Lab provided analysis technology for the SNARE complex developed by Ibata。

posted on 05/10/2024 12:58 AM

A review article was published in Experimental Medicine (special issue)

 Experimental Medicine Special Issue April 2024 “Neuroscience opened up by large-scale data and AI”A review article by Mr. Takano and Mr. Sogabe titled ``The shape of synapses elucidated by proximity labeling and expansion microscopy'' was published in。

posted on 04/23/2024 1:44 PM

Congratulations on your success, Takano-san!

Mr. Takano、Promoted as an independent associate professor in the field of brain function and molecular systems at Kyushu University Institute of Advanced Research and Biodefense Medicine.。Thank you for meeting me! Busy with moving work、We had a small celebration party with champagne.。

posted on 03/06/2024 3:31 PM

The Purple Ribbon Medal Celebration Party was held.

2024Yuzaki at the Imperial Hotel on March 3, 2017.Purple Ribbon Medal Celebrationwas held。Despite the sunny Sunday、Approximately 100 people gathered from all over the country.。Thank you very much again。(Tokyo Marathon was being held on the road in front of the hotel.)。)

posted on 03/03/2024 3:23 PM

Physiology class reunion was held

It was canceled for a while due to the coronavirus pandemic.Physiology class reunion was held。In the first half, there was a lecture by Professor Ayako Ishida, who studied abroad at the Yuzaki Lab and now works independently as a team leader at RIKEN CBS.、In the second half, we moved to the restaurant park to exchange opinions.、And it ended with the regular chorus of young blood.。

posted on 02/11/2024 10:44 AM

The results of joint research with Hoshino Lab were published in Nat Commun

in the central nervous system、Astrocytes clear glutamate from the synaptic cleft.、Achieves proper synaptic function。However、How does the astrocytic glutamate transporter GLAST function around synapses?、it was still unclear。In this paper、Cell adhesion molecule (DSCAM) expressed in Purkinje cells、By controlling the localization of GLAST expressed in Bergmann glia、Climbing fibers were shown to be involved in Purkinje cell synapse formation and cerebellar motor learning.。This is a huge amount of work done by Mr. Dewa of Hoshino Lab.。For the Yuzaki lab, Kakegawa was in charge of electrophysiological analysis and eye movement learning test.。Nat Commun. 15:458, 2024.

posted on 02/03/2024 10:52 AM

The results of joint research with Hamachi Lab have been published in PNAS

How to covalently chemically label proteins without genetic manipulation、A powerful method for analyzing receptors。However、Selective target receptor labeling in the brain has not yet been established。there、In this research led by Mr. Nonaka of Kyoto University's Hamachi Laboratory,、using ligand-directed chemical reactions、We show that synthetic probes can selectively bind to target endogenous receptors in the brain of living mice。Kakegawa of Yuzaki Lab、As part of the joint research between CREST and ERATO, Arai、In this study, we showed that chemical labeling does not change receptor function.。Proc Natl Acad Sci USA. 121:e2313887121, 2024

posted on 01/31/2024 10:22 AM

Research Highlight has been published in Cell Research

GABA acts as a ligand for GluD1、A paper by Pierre Paoletti, Radu Aricescu et al. that reported that it promotes long-term potentiation of inhibitory synapses.(Science 2023)Mr. Ito wrote an explanatory article, Research Highlight, about (Ito and Yuzaki, Cell Research)。

posted on 01/24/2024 11:33 AM

Gave a lecture at the University of Bergen

Sponsored by Dept Biomedicine at the University of Bergen, NorwayAt BBB Seminar、Yuzaki gives a lectureThe we。It's a polar night and there's almost no daylight.、It was a rare heavy snow day even in Bergen, but we enjoyed a lively discussion.。

posted on 01/18/2024 10:19 AM

Brain Club was held with Dr. Keiko Muguruma.

The 162nd Brain Club welcomed Dr. Keiko Muguruma (Kansai Medical University School of Medicine)。The title of the presentation is "Brain development and disease research using pluripotent stem cells"。Please explain the development of technology for differentiating brain tissue from ES cells and iPS cells, which is rooted in developmental biology research, with historical considerations in mind.、Finally, he talked about the current status and prospects of application to disease research.。Along with the importance of brain embryology research、We learned about the difficulty and fun of creating brain tissue from human-derived iPS cells, which take time for brain development.。

posted on 11/30/2023 6:53 PM

Brain Club was held with Dr. Takero Saneyoshi.

The 161st Brain Club welcomed Dr. Takero Saneyoshi (Kyoto University)。The title of the presentation was ``Cofilin inside the dendritic spine exhibits molecular activity through liquid-liquid phase separation."forming a sexual gradient"。Long-term potentiation (LTP) is considered a fundamental process of memory learning.) paper、Structural changes occur in which dendritic spines become larger over time, but the mechanism was not fully understood.。Dr. Saneyoshi found that the temporarily increased Ca concentration within the spine、Continuously activates calmodulin kinase (CaMKII) and its downstream enzymes.、As a result, the mechanism that changes the actin skeleton has been successfully clarified.。We all listened with great interest.。

posted on 11/29/2023 6:45 PM