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    Yuzaki Lab's (Department of Neurophysiology, Keio University School of Medicine) research theme is to elucidate "how neural activity and environmental changes induce memory and learning,、, 、and how they change the neural network itself ."。For details please Click here.
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Synapse formation mechanism by the C1q family protein(Neurosci Res)2016.11.12
Matsuda K. Synapse organization and modulation via C1q family proteins and their receptors in the central nervous system. Neurosci Res in press, 2016.

It is Invited Review for synapse formation mechanism by complement C1q family proteins by Keiko Matsuda lecturer。

Cbln1 controls the "non" motor learning(J Neurosci)2016.11.18
Otsuka S, Konno K, Abe M, Motohashi J, Kohda K, Sakimura K, Watanabe M, Yuzaki M. Roles of Cbln1 in Non-Motor Functions of Mice. J Neurosci 36 :11801-11816, 2016.

Cerebellum is thought to be involved in non-motor learning in motor learning and other。actually、Cbln1 and GluD2 but we know it is possible to control the selectively expressed in synapse formation in the cerebellum synapse、By these genetic mutations will occur human cognitive impairment。But these disorders was not clear about whether due to abnormality in the cerebellum。In this study、By examining fear conditioning training using mice lacking forebrain or cerebellum specifically Cbln1、Cbln1 each expressing before the brain and cerebellum、That you are responsible for specific functions in fear conditioning learning it was revealed for the first time。Otsuka is Mr. of the thesis of yuzu 﨑研。Hokkaido University Ken Watanabe of Konno teacher (co-first author)、It is the result of joint research with Abe teacher of Niigata Osaki village Research。

Involvement of δ2 receptor on heart fear conditioning learning(PLoS One)2016.11.14
Kotajima-Murakami H, Narumi S, Yuzaki M, Yanagihara D. Involvement of GluD2 in Fear-Conditioned Bradycardia in Mice. PLoS One 11:e0166144, 2016.

δ2 glutamate receptor (GluD2) is、It has been known to be involved in a variety of non-motor learning。In the present study was to clarify the involvement of GluD2 for bradycardia reaction of the heart caused by the fear stimulus。It is Kotajima's your work of the University of Tokyo Yanagihara laboratory。

The structure of the bridge that connects between the nerve cells and nerve cells(Science)2016.7.15
Elegheert J, Kakegawa W, clay, Shanks N, Behiels e, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Them so M *, Aricescu AR *. Structural basis for integration of GluD receptors within synaptic organizer complexes.  Science 353:295-299, 2016.(*co-corresponding author).

In small brain circuit、Presynaptic releases a complement family molecule Cbln1、It will combine to Nrx present in the presynaptic。On the other hand、Cbln1 will cause the synapse formed by combining at the same time also to the postsynaptic delta type 2 glutamate receptor (GluD2)。Nozawa-kun, together with Hayashi-san、Nrx-Cbln1-GluD2 the structure of the three-party complex that was the first time Tokiakasa。as a result、Cbln1 not only serve to anchor the presynaptic and postsynaptic as adhesive、To adjust the work of the GluD2 of postsynaptic、Synaptic plasticity (long-term depression (LTD)) It is possible to control the now clear。This study is a result of joint research with Aricescu Dr. Oxford University、It is a joint responsibility author paper。

Development of methods of artificially chemically activated glutamate receptors(Nature Chemistry)2016.6.28
Kiyonaka S, Kubota R, Michibata Y, Sakakura M, Takahashi H, Numata T, Inoue R, Yuzaki M, Hamachi I. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells. Nature Chemistry 8 :958-967, 2016.

Glutamate receptors conformation of the ligand binding site will change by the binding of glutamate。It introduced two His residues to the appropriate site of the ligand binding site、By varying the conformation by Pd molecules administration、Methods of modulating artificially activated, inactivation of ionotropic and metabotropic glutamate receptors has been developed。This study is your work of Ken Kyoto University Hamachi。Yuzusakiken has participated as CREST sharing research。

C1q-like protein "、It controls the position and function of the kainate receptor beyond the synapse(Neuron)2016.4.28
Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. Trans-synaptic modulation of kainate receptor functions by C1q-like proteins.  Neuron. 2016 May 18;90(4):752-67.

Kainate receptors of the glutamate receptor、There was particularly high in specific synapses of the hippocampus, an important brain region in memory and learning、The transmission rate that is slow not to other receptors、And the essential role in the integration of hippocampal neural network activity。However、Whether incorporated only to certain synaptic kainate receptors what mechanism、The mechanism was not well understood。In this paper, the、By neurons secrete proteins called the C1ql2 and C1ql3、I found that coming to collect the kainate receptors directly。further、In the hippocampus of mice lacking the C1ql2 and C1ql3、Kainate receptors is not incorporated into the synapse、Be less likely to occur epileptic seizures was found be given a stimulus to induce epileptic artificially。C1ql2、C1ql3 is also present in various brain regions、Are considered each by controlling the built-in and function of kainate receptor synaptic neural make up the appropriate neural network activity。The results of this research、It is expected to be of use in the therapy method development and cause elucidation of epilepsy and autism。Keiko Matsuda is a lecturer and Tim Budisantoso Mr. of work。

Notch signaling controls the expression of synaptic vesicle protein in excitatory neurons(Scientific Reports)2016.4.7
Hayashi Y, Nishimune H, Hozumi K, And saga, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of
synaptic vesicle proteins in excitatory neurons.  Sci Rep2016 Apr 4;6:23969.
doi: 10.1038/srep23969. PubMed PMID: 27040987.
A paper on the regulation of expression of the synaptic vesicle protein by Notch signaling has been published in Scientific Reports。Takeo Assistant Professor (Adjunct) is the work that was carried out in Tomita Research。

Mathematical model of the cerebellar LTD by AMPA receptor dual phosphorylation(PLOS Computational Biology)2016.1.28
AR Gallimore, Aricescu AR, Yuzaki M, Calinescu R. A Computational Model of the GluA2-Y876/GluA2-S880 Master Switch for Cerebellar Long-Term Depression. PLOS Computational Biology12(1): e1004664. doi:10.1371/journal.pcbi.1004664.
δ2 receptors by controlling the tyrosine phosphorylation of the AMPA receptor GluA2 subunit、Adjacent to the tyrosine phosphorylation sites of GluA2 is a computer simulation based on our discovery that controlling the serine phosphorylation。Is it really beautifully reproduced the behavior of the cerebellum LTD。