Translation

Welcome to Yuzaki Lab

・柚﨑研は慶應義塾大学 ヒト生物学-微生物叢-量子計算研究センター(WPI-Bio2Q)に移動しました。

・中枢神経系に加えて、末梢・自律・腸管神経系でのシナプス形成機構に焦点をあて、神経系と多臓器の連関機構やその破綻による病態の解明と治療法の開発を目指します。

Past News

Journal Club

2024/05/20 Journal Club (Kakegawa)

Wang et al. (Dr. Bender group)

Neuron. 2024 May 1;112(9):1444-1455.e5. doi: 10.1016/j.neuron.2024.01.029. Epub 2024 Feb 26.

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.

posted on 05/18/2024 6:22 PM

2024. 5. 13 Journal club (Arai)

Neuron. 2024 Apr 26:S0896-6273(24)00248-4. doi: 10.1016/j.neuron.2024.04.010.

Online ahead of print.

Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells

Elizabeth P Lackey, Luis Moreira, Aliya Norton, Marie E Hemelt, Tomas Osorno, Tri M Nguyen, Evan Z Macosko, Wei-Chung Allen Lee, Court A Hull, Wade G Regehr

PMID: 38692278

posted on 05/13/2024 11:00 AM

2024.4.15 Journal club (Takeo)

Jiaxing Li, Tania G. Miramontes, Tim Czopka & Kelly R. Monk

Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation

Nature Neuroscience volume 27, pages219–231 (2024)

posted on 04/12/2024 8:32 PM

2024/4/1 Journal Cub (松田)

https://www.nature.com/articles/s41593-024-01585-8

posted on 04/01/2024 9:14 AM

2024/03/18 Journal Club (Dilina)

Interaction of an a-synuclein epitope with HLA- DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease

Francesca Garretti, Connor Monahan, Nicholas Sloan, …, Ellen Kanter, Dritan Agalliu, David Sulzer

Neuron 111, 3397–3413; Published: November 1, 2023

PMID: 37597517  DOI: 10.1016/j.neuron.2023.07.015

posted on 03/15/2024 1:28 PM

2024/3/11 Journal Club (Shiozaki)

Lateral olivocochlear neurons modulate cochlear responses to noise exposure

Austen A. Sitko1 *, Michelle M. Frank1 *, Gabriel E. Romero1 *, Lisa V. Goodrich1

1 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA

https://doi.org/10.1101/2024.03.04.583418

posted on 03/08/2024 7:13 PM

2024/1/31 Journal club (Oishi)

Circuit mechanism for suppression of frontal cortical ignition during NREM sleep

Bing Li, Chenyan Ma,Yun-An Huang, Xinlu Ding, Daniel Silverman, Changwan Chen, Dana Darmohray, Lihui Lu, Siqi Liu,Gabriel Montaldo, Alan Urban, and Yang Dan*

Cell

VOLUME 186, ISSUE 26, P5739-5750.E17, DECEMBER 21, 2023

https://www.cell.com/cell/fulltext/S0092-8674(23)01229-1

posted on 01/31/2024 8:52 PM

2023/12/04 Journal Club (Takasugi)

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon

Rachel L. Wolfson,1,2,3 Amira Abdelaziz,1,2 Genelle Rankin,1,2 Sarah Kushner,1,2 Lijun Qi,1,2 Ofer Mazor,1 Seungwon Choi,1,2 Nikhil Sharma,1,2,4 and David D. Ginty1,2,5,*

https://www.cell.com/cell/pdf/S0092-8674(23)00740-7.pdf

posted on 12/03/2023 10:17 PM

2023/11/20JC (Ishikawa)

The projection-specific signals that establish
functionally segregated dopaminergic synapses

Cell 2023 Aug 31;186(18):3845-3861.e24. doi: 10.1016/j.cell.2023.07.023.

Akiko Terauchi, Patricia Yee,Erin M. Johnson-Venkatesh, David D. Ginty, Wei-Chung A. Lee,Hisashi Umemori

posted on 11/20/2023 12:46 AM

2023/11/06 Journal Club (Yuzaki)

今回はシンガポールで行われたA Symposium on Neuroscience of Dementiaの内容をシェアします。特にKeynote Lectureの一つDr. Hee-Sup Shinの講演について元となったいくつかの論文を紹介します。
resumeはSlackで配布します。

I will report on the proceedings of “A Symposium on the Neuroscience of Dementia,” which was recently held in Singapore. In particular, I will introduce the following two papers, on which the one of the keynote lectures by Dr. Hee-Sup Shin was based.
The resume will be distributed via Slack.

Key reference:
1.Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.
Kim SW, Kim M, Baek J, Latchoumane CF, Gangadharan G, Yoon Y, Kim DS, Lee JH, Shin HS.
Neuron. 2023 Feb 1;111(3):418-429.e4. doi: 10.1016/j.neuron.2022.11.001.PMID: 36460007

2.A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse.
Keum S, Kim A, Shin JJ, Kim JH, Park J, Shin HS.
Neuron. 2018 May 2;98(3):588-601.e5. doi: 10.1016/j.neuron.2018.03.041. PMID: 29681532

posted on 11/05/2023 4:35 PM

2023/10/16 Journal Club (M. Itoh)

A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors.

Boudkkazi S, Schwenk J, Nakaya N, Brechet A, Kollewe A, Harada H, Bildl W,

Kulik A, Dong L, Sultana A, Zolles G, Schulte U, Tomarev S, Fakler B.

Neuron. 2023 Aug 16;111(16):2544-2556.e9. doi: 10.1016/j.neuron.2023.07.013. PMID: 37591201

posted on 10/13/2023 5:19 PM

2023. 8. 28 Journal club (Arai)

Nat Commun. 2023 May 30;14(1):3113. doi: 10.1038/s41467-023-38854-2.

Afferent convergence to a shared population of interneuron AMPA receptors

Reagan L Pennock, Luke T Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I Wadiche

PMID: 37253743

posted on 08/28/2023 8:22 AM