Endosomal hyper-acidification via proton-activated chloride channel delation in neurons impairs AMPA receptor endocytosis and LTD.

Kevin H. Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard Huganir, Zhaozhu Qiu: bioRxiv (posted September 30, 2024)

BioRxiv

A dendritic substrate for temporal diversity of cortical inhibition

Annunziato Morabito, Yann Zerlaut, Dhanasak Dhanasobhon, Emmanuelle Berthaux, Alexandra Tzilivaki, Gael Moneron, Laurence Cathala, Panayiota Poirazi, Alberto Bacci, David DiGregorio, Joana Lourenço, Nelson Rebola
doi: https://doi.org/10.1101/2024.07.09.602783

Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity

Matsumoto N, Barson D, Liang L, Crair MC.

Science 2024 Aug 16;385(6710):eadh7814. doi: 10.1126/science.adh7814. Epub 2024 Aug 16

https://www.sciencedirect.com/science/article/pii/S0896627324004537?via%3Dihub#sec2

Adaptation to photoperiod via dynamic neurotransmitter segregation

Maddaloni , Y. J. Chang , R. A. Senft & S. M. Dymecki

Department of Genetics, Harvard Medical School

Nature. 632, pages 147–156 (2024); Published: August 1, 2024

PMID: 39020173  DOI: 10.1038/s41586-024-07692-7

Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development.

Wang DC, Santos-Valencia F, Song JH, Franks KM, Luo L.

Neuron. 2024 Jun 27:S0896-6273(24)00414-8. doi: 10.1016/j.neuron.2024.06.007. Epub ahead of print. PMID: 38964330.

Integrity of neural extracellular matrix is required for microglia-mediated synaptic remodeling.

C. Cangalaya, W. Sun, S. Stoyanov, I. R. Dunay, A. Dityatev,

GLIA, doi: 10.1002/glia.24588 (2024).

GLP-1-directed NMDA receptor antagonism for obesity treatment

Jonas Petersen, Mette Q Ludwig, Vaida Juozaityte, et al.

Nature. 2024 May;629(8014):1133-1141.
DOI: 10.1038/s41586-024-07419-8

The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders.

Tasnim, A., Alkislar, I., Hakim, R. et al.

Nat Neurosci 27, 484–496 (2024). https://doi.org/10.1038/s41593-023-01552-9

皆様、

山崎が担当の6/17のJournal clubは、以下の論文を紹介させていただきます。

11時開始になります。どうぞよろしくお願いいたします。

Cell Rep. 2024 Jan 23, 43: 113634

Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity

Miyazaki et al.,

https://www.sciencedirect.com/science/article/pii/S2211124723016455?via%3Dihub

所用のため、時間が取れなかったので、今回は同じラボからの次の2報を概説してdiscussionします。
Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons
Stephanie C Gantz, Khaled Moussawi, Holly S Hake
eLife 2020;9:e56054.

LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
Aleigha Gugel, Erik A Ingebretsen, Holly S Hake, Stephanie C Gantz
Neuropsychopharmacology 2024 May;49(6):1014-1023.

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.

Araki Y, Rajkovich KE, Gerber EE, Gamache TR, Johnson RC, Tran THN, Liu B, Zhu Q, Hong I, Kirkwood A, Huganir R.

Science. 2024 Mar;383(6686):eadk1291. doi: 10.1126/science.adk1291. Epub 2024 Mar 1.

PMID: 38422154

https://pubmed.ncbi.nlm.nih.gov/38422154/

https://www.science.org/doi/10.1126/science.adk1291