Translation

Welcome to Yuzaki Lab

・柚﨑研は慶應義塾大学 ヒト生物学-微生物叢-量子計算研究センター(WPI-Bio2Q)に移動しました。

・中枢神経系に加えて、末梢・自律・腸管神経系でのシナプス形成機構に焦点をあて、神経系と多臓器の連関機構やその破綻による病態の解明と治療法の開発を目指します。

Past News

Journal Club

2025/5/12 Journal Club (Suyama)

Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

Míriam Toledo, Sara Martínez-Martínez, Matthias Van Hul…Patrice D Cani , Rubén Nogueiras, Marc Claret
Nat Metab. 2025 Apr 22.
doi: 10.1038/s42255-025-01280-3.

posted on 05/10/2025 8:26 PM

2025/4/28 Journal club (Thomas)

Thomas presented the following paper

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Wright et al., Science, 2025

https://www.science.org/doi/10.1126/science.ads4706#supplementary-materials

posted on 04/28/2025 1:44 PM

2025/04/21 Journal Club (Dilina)

TNF-NF-kB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

Tae Wan Kim, So Yeon Koo, Markus Riessland, …, Ralph Garippa, Doron Betel, Lorenz Studer.

Cell. 187,3671–3689, Published. July11,2024.

PMID: 38866017. DOI: 10.1016/j.cell.2024.05.030

posted on 04/18/2025 8:16 PM

2025.02.17 Journal club (Ishikawa)

Visual experience reduces the spatial redundancy between cortical feedback inputs and primary visual cortex neurons
Neuron (2024)112(19):3329-3342.. doi: 10.1016/j.neuron.2024.07.009. Epub 2024 Aug 12.

Rodrigo F Dias , Radhika Rajan , Margarida Baeta , Beatriz Belbut , Tiago Marques , Leopoldo Petreanu

posted on 02/16/2025 1:12 PM

2025.2.10 Journal club (Thomas)

“Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites.” Cell vol. 188,2 (2025): 484-500.e22. doi:10.1016/j.cell.2024.11.029 Benedetti, Lorena et al.

posted on 02/10/2025 11:44 AM

2025.1.27 Journal club (Arai)

Nat Commun. 2024 Dec 12;15(1):10340. doi: 10.1038/s41467-024-53901-2.
Membrane potential states gate synaptic consolidation in human neocortical tissue
Mittermaier and Geiger et al.

posted on 01/27/2025 8:34 AM

2025/1/20 Journal Club (Shiozaki)

Defects in hair cells disrupt the development of auditory peripheral circuitry

Bottom, R.T., Xu, Y., Siebald, C. et al. Defects in hair cells disrupt the development of auditory peripheral circuitry. Nat Commun 15, 10899 (2024). https://doi.org/10.1038/s41467-024-55275-x

posted on 01/18/2025 9:14 PM

2025年1月6日 Journal Club (松田)

https://www.nature.com/articles/s41593-024-01813-1#Sec1

posted on 01/04/2025 5:25 PM

2024/12/16 Journal Club (Haowei Li)

Hypothalamic deep brain stimulation augments walking after spinal cord injury.

Cho, N., Squair, J.W., Aureli, V. et al.
Nat Med 30, 3676–3686 (2024).
https://doi.org/10.1038/s41591-024-03306-x

posted on 12/14/2024 8:14 PM

2024/12/2 Journal Club (Takasugi)

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.

Nees, T.A., Wang, N., Adamek, P. et al. Nat Commun 14, 1899 (2023). https://doi.org/10.1038/s41467-023-37602-w

posted on 12/02/2024 3:38 PM

2024/1125 Journal Glub(A.Ishikawa)

NMDA receptors regulate the firing rate set point
of hippocampal circuits without altering
single-cell dynamics

Neuron
. 2024 Nov 5:S0896-6273(24)00735-9. doi: 10.1016/j.neuron.2024.10.014. Online ahead of print.

 

posted on 11/24/2024 8:06 PM

2024/11/18 Journal Club (M. Itoh)

Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization.

Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH.

Nat Struct Mol Biol. 2024 Oct;31(10):1601-1613. doi: 10.1038/s41594-024-01369-5. Epub 2024 Aug 13.

PMID: 39138332

https://pubmed.ncbi.nlm.nih.gov/39138332/

https://www.nature.com/articles/s41594-024-01369-5

posted on 11/15/2024 5:03 PM