Graduate student of Ishida's paper is now Accept the Journal of Neuroscience。Congrats。It was featured in the preface of TWIJ page as this week of attention paper。

Although this variety of synapse formation factors have been known to date、Ya what activity was confirmed in the individual brain (in vivo)、There is no little thing that action has been confirmed in the brain after mature。We are the administration of molecules that are secreted by nerve cells that Cbln1 the cerebellum of adult mice、2A new synapses are formed within days、Movement disorders of cerebellar ataxia mouse has discovered that remission。But since the effect is temporary、Cbln1 that there was sustained was found to be necessary for the maintenance of normal synaptic。

Cbln1 and because the family molecules are also expressed in brain regions other than the cerebellum、By elucidating the signaling system through Cbln1、I can better understand the formation and maintenance of synapses in the adult brain、as a result、It will be expected to lead to elucidation of conditions such as movement disorders and memory impairment。

Graduate student relationship God-kun of the paper is now Accept the Keio Journal of Medicine。Congrats。

Cerebellum exercise learning、It is believed to have been borne by long-term suppression phenomenon of cerebellar granule cells over Purkinje cell synaptic transmission (LTD)。Although the LTD we know that there is a need for protein kinase C and delta type 2 glutamate receptor、The detailed molecular mechanism is unknown。It was first demonstrated that not to participate in the LTD to be directly phosphorylated by protein kinase C in a delta receptor itself in this paper。

Kakegawa Assistant Professor was awarded the 2007 Japan Physiological Society Award。Congrats!

Mr. Ishida, a healthy baby girl graduate (3265g; Apgar 9-10-10) was born。It is Chie-chan。Congrats!

Thesis of Matsuda Assistant Professor is now Accept the Neuron。Congrats。

AMPA receptor is responsible for the fast neurotransmitter in our brain、We have to control the memory and learning process。AMPA receptors are usually transported to the postsynaptic (dendrites)、Do not go to the presynaptic (axons)。The mechanism of this "polar transport" It was long a mystery、We、AP-4 of the adapter protein that controls the vesicular transport membrane proteins、Was the first time revealed that responsible for this polarity transport。further、Since AMPA receptors that are erroneously transported to the axon is decomposed captured by autophagosomes transchromosomic internally axon、AP-4 is to be involved in autophagy activity has been suggested。

This work is the result of joint research with Hokkaido University Miura, Watanabe teacher。

Baby girl first child was born in Kakegawa Assistant Professor。It is auction-chan。Congrats!!

Kakegawa Assistant Professor of paper is now Accept the Journal of Neuroscience。

Delta 2 receptors、It is essential for synapse formation in the cerebellum、At the same time synaptic plasticity phenomena underlying course of motor learning (long-term depression：Controls LTD)。In other words、Delta receptor is a unique molecule that controls the functional synaptic plasticity and morphological synaptic plasticity。By our lab work so far、Delta 2 receptors、Although it belongs to ionotropic glutamate receptor family、It does not bind to glutamate、And it has been reported that does not function as an ion channel。

In this study the intracellular site of delta 2 receptors (C-terminal) is、It is essential for functional synaptic plasticity features such as LTD and motor learning (eyeblink conditioning)、On the other hand、The morphological synapse formation was the first time revealed that the C-terminus is not essential。In other words、Delta 2 receptors、Through the C-terminal controls the functional synaptic plasticity、Other sites、Probably involved in morphological synapse formation through the extracellular domain (N-terminal)、It is thought that each driving a separate signaling system。

Graduate students of Nishiyama Mr. of paper is now Accept the Autophagy magazine。Congrats。

The relationship between the nerve cell death and autophagy has been attracting attention。For example,、In lurcher mutant mice、When the Delta 2 receptor is constantly activated、Neurodegenerative be seen along with the enhancement of autophagy in Purkinje cells。This molecular mechanism has been conducting research in our laboratory。

In this research、The Atg5 gene is essential for autophagy pathway has been created and studied the Purkinje cell-specific defects are not mice。Prior to denaturation of the Purkinje cells Interestingly、Swelling of the axons is observed、Image intracellular membrane structure is accumulation was observed in tumor most。It is considered an important finding in considering the origin and role of the auto phagocytosis transchromosomic in nerve cells。(Is a joint research with Ken Watanabe Medicine and Dentistry of Ken Mizushima Hokkaido University。）

Journal of Physiology paper is Assistant Professor Kakegawa (London)Now Accept to。Congrats。

Delta 2 receptors、Although it belongs to ionotropic glutamate receptor family、Whether it is unknown still what is functioning as an ion channel。In this paper、The channel domain was mutated to "channel dead" delta 2 receptor、By expressing the delta receptor null mutant mice、It was the challenge of this problem。

Surprisingly、"Channel dead" delta 2 receptors、As with normal delta 2 receptor、From to restore the cerebellum LTD failure、Delta 2 receptor is now for the first time clear that does not function as an ion channel。

Koda lecturer of paper is Publish to Eur J Neurosci、It was on the cover。Congrats。

Although the delta receptor is a molecule that controls the long-term depression (LTD) which is a basis course of motor learning in the cerebellum、It was so far unknown how the function to。In this paper、To deficient cerebellum the delta 2 receptor、By introducing a delta receptor with a viral vector、The LTD succeeded to be restored。

Interestingly、When the deficient C-terminus of the intracellular domain of Delta 2 receptor、That the LTD induction function of the delta 2 receptor is lost it was found。As a result、Delta 2 receptors、Rather than ionotropic glutamate receptor、Function as metabotropic receptors that transmit signals through the intracellular domain was suggested。

Iijima an assistant of the marriage celebration was conducted by Alice Garden。You happy!!

Joint research with RIKEN BSI FuruichiKen is now Accept the Journal of Neuroscience magazine。Kakegawa Assistant Professor has electrophysiological analysis of parallel fibers over Purkinje cells neurotransmission another Lobule of the cerebellum。