A paper by Kakegawa has been published in Journal of NeuroscienceIt became Accept to。Under the title "top N-terminal region of δ2 receptors rapidly induce cerebellar parallel fiber synapses in in vivo"、It is a joint research with Miyazaki Watanabe teacher of Hokkaido University。「It has been featured in "This Week in The Journal." "As was featured in this week's attention paper。

The last paper (J. Neurosci. 28:1460-1468, 2008)so、Delta 2 receptors controls the LTD signal transduction system via intracellular domain (C-terminal)、From that had been proposed to control the morphological synapse formation via a separate extracellular domain (N-terminal)。We found that it is actually induced synapse formation delta 2 receptor in just one day after when expressed in the cerebellum of the mature animal using a viral vector in this paper。We also see that the N-terminal domain is necessary and sufficient for this action。

Assistant Professor Iijima's paperJournal of NeuroscienceIt became Accept to。"Cbln1 is expressed suppressed by neural activity - homeostatic control in the development stage and mature stage" is the title of。

We、We previously reported that the new secreted factor Cbln1 is essential to maintain and synapse formation between cerebellar granule cells and Purkinje cells。In this paper、When neural activity in granule cells continuously increased to Cbln1 expression is decreased、As a result, we found that the synapse is out。With such a mechanism、Or maintaining the homeostasis prevent over-excitement、Possibility of motor learning related to that and go synaptic modification is suggested。

Invited review of Yuzusaki became in press in the cerebellum special issue of Neuroscience magazine。The title of "synaptic morphology and plasticity of the control mechanism by the two new molecules delta 2 receptor and Cbln1- old."。

Paperback review where the citrus fruit "Handbook of Neurochemistry & Now and in press in the Molecular Neurobiology "。It is titled "glutamate receptor -NMDA receptor and delta receptor"。

Matsuda (Megumi) thesis of Assistant Professor Kondo visiting researcher co-author is now Accept the European Journal of Neuroscience。
The Matsuda (Megumi) Assistant Professor and Miura Hokkaido University、Now Accept the joint research also European Journal of Neuroscience of the Watanabe teacher。

In the two papers is a new secretory synapse formation factor Cbln1 is、It is what was revealed for the first time to specifically bind to the postsynaptic membrane between cerebellar granule cells and Purkinje cells。That specific receptor has clearly indicated the presence at this site。
Despite using a completely different approach、This is where the fun was arrived at a common conclusion。

Graduate students of Ishida was appointed as Society for the Promotion of Science Research Fellow -SPD from the next fiscal year。Congrats!

Thesis of Matsuda Assistant Professor is now Accept the Autophagy magazine。this is、This invited paper as an Addendum to the Neuron paper。

Matsuda Assistant Professor is、He was awarded the 2008 of the Japan Neuroscience Society Award。Congrats!

Graduate student of Ishida's paper is now Accept the Journal of Neuroscience。Congrats。It was featured in the preface of TWIJ page as this week of attention paper。

Although this variety of synapse formation factors have been known to date、Ya what activity was confirmed in the individual brain (in vivo)、There is no little thing that action has been confirmed in the brain after mature。We are the administration of molecules that are secreted by nerve cells that Cbln1 the cerebellum of adult mice、2A new synapses are formed within days、Movement disorders of cerebellar ataxia mouse has discovered that remission。But since the effect is temporary、Cbln1 that there was sustained was found to be necessary for the maintenance of normal synaptic。

Cbln1 and because the family molecules are also expressed in brain regions other than the cerebellum、By elucidating the signaling system through Cbln1、I can better understand the formation and maintenance of synapses in the adult brain、as a result、It will be expected to lead to elucidation of conditions such as movement disorders and memory impairment。

Graduate student relationship God-kun of the paper is now Accept the Keio Journal of Medicine。Congrats。

Cerebellum exercise learning、It is believed to have been borne by long-term suppression phenomenon of cerebellar granule cells over Purkinje cell synaptic transmission (LTD)。Although the LTD we know that there is a need for protein kinase C and delta type 2 glutamate receptor、The detailed molecular mechanism is unknown。It was first demonstrated that not to participate in the LTD to be directly phosphorylated by protein kinase C in a delta receptor itself in this paper。

Kakegawa Assistant Professor was awarded the 2007 Japan Physiological Society Award。Congrats!

Mr. Ishida, a healthy baby girl graduate (3265g; Apgar 9-10-10) was born。It is Chie-chan。Congrats!

Thesis of Matsuda Assistant Professor is now Accept the Neuron。Congrats。

AMPA receptor is responsible for the fast neurotransmitter in our brain、We have to control the memory and learning process。AMPA receptors are usually transported to the postsynaptic (dendrites)、Do not go to the presynaptic (axons)。The mechanism of this "polar transport" It was long a mystery、We、AP-4 of the adapter protein that controls the vesicular transport membrane proteins、Was the first time revealed that responsible for this polarity transport。further、Since AMPA receptors that are erroneously transported to the axon is decomposed captured by autophagosomes transchromosomic internally axon、AP-4 is to be involved in autophagy activity has been suggested。

This work is the result of joint research with Hokkaido University Miura, Watanabe teacher。