GLP-1-directed NMDA receptor antagonism for obesity treatment

Jonas Petersen, Mette Q Ludwig, Vaida Juozaityte, et al.

Nature. 2024 May;629(8014):1133-1141.
DOI: 10.1038/s41586-024-07419-8

UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression

Yi Nong, David C. Stoppel, Mark A. Johnson, Morgane Boillot, Jelena Todorovic, Jason Shen, Xinyu Zhou, Monica J.S. Nadler, Carrie Rodriguez, Yuda Huo, Ikue Nagakura, Ekkehard M. Kasper, Matthew P. Anderson
doi: https://doi.org/10.1101/2023.02.28.530462

Nature 609: 374–380. Published online 13 July 2022
Dopamine subsystems that track internal states.
Grove JCR, Gray LA, La Santa Medina N, Sivakumar N, Ahn JS, Corpuz TV, Berke JD, Kreitzer AC, Knight ZA
DOI: 10.1038/s41586-022-04954-0

Reverse-translational identification of a cerebellar satiation network

Aloysius Y T Low, Nitsan Goldstein, Jessica R Gaunt, Kuei-Pin Huang , Norliyana Zainolabidin, Alaric K K Yip, Jamie R E Carty, Ju Y Choi, Alekso M Miller, Helen S T Ho, Clara Lenherr, Nicholas Baltar, Eiman Azim, October M Sessions, Toh Hean Ch’ng, Amanda S Bruce, Laura E Martin , Mark A Halko, Roscoe O Brady Jr, Laura M Holsen, Amber L Alhadeff, Albert I Chen, J Nicholas Betley

Nature. 2021 Dec;600(7888):269-273. doi: 10.1038/s41586-021-04143-5. Epub 2021 Nov 17.

The Journal of  Clinical Investigation. 2021 Apr 13

Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward auto-activation loop in mice

Luis Varela, Bernardo Stutz, Jae Eun Song, Jae Geun Kim, Zhong-Wu Liu, Xiao-Bing Gao, and Tamas L. Horvath

DOI: 10.1172/JCI144239

Pancreatic Islets Communicate With the Brain via Vagal Sensory Neurons
Madina Makhmutova, Jonathan Weitz, Alejandro Tamayo, Elizabeth Pereira, Joana Almaça, Rayner Rodriguez-Diaz, Alejandro Caicedo
bioRxiv 780395; doi: https://doi.org/10.1101/780395

Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus.

Claire Gao, Yan Leng, Jun Ma, Victoria Rooke, Shakira Rodriguez-Gonzalez, Charu Ramakrishnan, Karl Deisseroth & Mario A. Penzo
Nature Neuroscience volume 23, pages217–228(2020)

Neuron. 2019;102:653–6.
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits
Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, et al. Neuron. Cell Press; 2019.

Journal club by Shigetomo Suyama