Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

journal club @ 2023-07-24 by T. Yamasaki,,en,e3,,bg,j.neuron.2018.03.034,,en,Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors,,en,Regan MC,,en,Grant T,,en,McDaniel MJ,,en,Karakas E,,el,Zhang J,,zh-CN,Traynelis SF,,en,Grigorieff N,,af,Furukawa H,,en

I’d like to introduce the following paper published in Nature.

Inhibitory input directs astrocyte morphogenesis through glial GABABR

https://www.nature.com/articles/s41586-023-06010-x#Sec39

posted on 07/21/2023 2:20 PM

2023/7/10 Journal Club (Takeo)

Developmental Cell Available online 7 June 2023

Fujimoto S, Imai T et al.,

Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice

PMID: 37290446

posted on 07/07/2023 5:17 PM

Journal Club (Takano)

Spatially Resolved Proteomic Profiling Uncovers Structural and Functional Regulators of the Axon Initial Segment

bioRxiv, https://www.biorxiv.org/content/10.1101/2023.03.06.531334v1

posted on 07/03/2023 2:48 PM

2023/06/12 Journal Club (Dilina)

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Shu-Hsien Sheu, Sri Gokul Upadhyayula, …, david e. Clapham
Cell 185, 18; Published. 2022 Sep 1;
PMCID: PMC9789380 DOI: 10.1016/j.cell.2022.07.026

posted on 06/09/2023 2:31 PM

2023/6/5 Journal Club Shiozaki

Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

eLife, https://doi.org/10.7554/eLife.03564

posted on 06/05/2023 9:02 AM

2023/05/15 Journal Club (Oishi)

Cortico-cortical feedback engages active dendrites in visual cortex

Mehmet Fisek, Dustin Herrmann, Alexander Egea-Weiss, Matilda Cloves, Lisa Bauer, Tai-Ying Lee, Lloyd E. Russell & Michael Hausser

DOI: 10.1038/s41586-023-06007-6

posted on 05/12/2023 1:08 PM

2023/05/08 Journal Club (Suyama)

UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression

Yi Nong, David C. Stubble, Mark A. Johnson, Morgane Boillot, Jelena Todorovic, Jason Shen, Xinyu Zhou, Monica J.S. Nadler, Carrie Rodriguez, Yuda Huo, Ikue Nagakura, Ekkehard M. Kasper, Matthew P. Anderson
doi: https://doi.org/10.1101/2023.02.28.530462

posted on 05/08/2023 10:11 AM

2023/05/01 Journal Club (Takasugi)

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

Shan Meltzer, Katelyn C. Boulanger, you M. Cyrillic, Emmanuella Osei-Asante, Michelle DeLisle, Qiyu Zhang, Brian T. Kalish, Anika Tasnim, Erica L. Huey, Leah C. Fuller, Erin K. Flaherty, Tom Maniatis, Andrew M. Garrett, Joshua A. Weiner, David D.. Ginty.

posted on 04/28/2023 7:07 PM

2023/04/17 Journal Club (Kakegawa)

Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human.
Silas E. Busch and Christian Hansel, bioRxiv (April 6 2023)

posted on 04/15/2023 2:48 PM

2023/04/10 Journal Club (Ishikawa)

Cardiogenic control of affective behavioural state.

Brian Hsueh et al., Nature 615, pages292–299 (2023)

posted on 04/09/2023 8:35 PM

2023/03/20 Journal Club (Yuzaki)

Engineered adhesion molecules drive synapse organization.
In Dylan Hale, Thomas C Südhof, Richard L Huganir
Proc Natl Acad Sci USA 120(3):e2215905120, 2023.

FYI:

Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
--Richard Sando, Milan Lyndie Ho, Xinran Liu, Thomas C. Südhof
J Cell Biol (2022) 221 (2): e202109111.

posted on 03/19/2023 3:00 PM

2023/03/13 Journal Club (M. Itoh)

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.
Gao Y, hongy, Huang L, Zheng S, Zhang H, Wang S, Yao Y, ZhaoY, Zhu L, Xu Q, Chai X, Zeng Y,
Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang YOU, Zheng Q, Xu H, Money X.
Cell. 2023 Mar 2;186(5):1026-1038.e20. doi: 10.1016/j.cell.2023.01.021.
PMID: 36868208

 

 

posted on 03/10/2023 6:20 PM