Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2024/05/20 Journal Club (Kakegawa)

Wang et al. (Dr. Bender group)

Neuron.. 2024 May 1;112(9):1444-1455.e5. doi: 10.1016/j.neuron.2024.01.029. Epub 2024 Feb 26.

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.

posted on 05/18/2024 6:22 PM

2024. 5. 13 Journal club (Arai)

Neuron.. 2024 Apr 26:S0896-6273(24)00248-4. doi: 10.1016/j.neuron.2024.04.010.

ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells

Elizabeth P Lackey, Luis Moreira, Aliya Norton, Marie E Hemelt, Tomas Osorno, Tri M Nguyen, Evan From Macosko, Wei-Chung Allen Lee, Court A Hull, Wade G Regehr

PMID: 38692278

posted on 05/13/2024 11:00 AM

2024.4.15 Journal club (Takeo)

Jiaxing Li, Tania G. Miramontes, Tim Czopka & Kelly R. Monk

Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation

Nature Neuroscience volume 27, pages219–231 (2024)

posted on 04/12/2024 8:32 PM

2024/4/1 Journal Cub (Matsuda)

https://www.nature.com/articles/s41593-024-01585-8

posted on 04/01/2024 9:14 AM

2024/03/18 Journal Club (Dilina)

Interaction of an a-synuclein epitope with HLA- DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease

Francesca Garretti, Connor Monahan, Nicholas Sloan, …, Ellen Kanter, Dritan Agalliu, David Sulzer

Neuron. 111, 3397–3413; Published: November 1, 2023

PMID: 37597517 DOI: 10.1016/j.neuron.2023.07.015

posted on 03/15/2024 1:28 PM

2024/3/11 Journal Club (Shiozaki)

Lateral olivocochlear neurons modulate cochlear responses to noise exposure

Austin A. Sitko1 *, Michelle M. Frank1 *, Gabriel E. Romero1 *, Lisa V. Goodrich1

1 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA

https://doi.org/10.1101/2024.03.04.583418

posted on 03/08/2024 7:13 PM

2024/1/31 Journal club (Oishi)

Circuit mechanism for suppression of frontal cortical ignition during NREM sleep

Bing Li, Chenyan Ma,Yun-An Huang, Xinlu Ding, Daniel Silverman, Changwan Chen, Darmohray Fund, Lihui Lu, Siqi Liu,Gabriel Montaldo, Alan Urban, and Yang And*

Cell

VOLUME 186, ISSUE 26, P5739-5750.E17, DECEMBER 21, 2023

https://www.cell.com/cell/fulltext/S0092-8674(23)01229-1

posted on 01/31/2024 8:52 PM

2023/12/04 Journal Club (Takasugi)

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon

Rachel L. Wolfson,1,2,3 Amira Abdelaziz,1,2 Genell Rankin,1,2 Sarah Kushner,1,2 Lijun Qi,1,2 Ofer Mazor,1 Seungwon Choi,1,2 Nikhil Sharma,1,2,4 and David D. Ginty1,2,5,*

https://www.cell.com/cell/pdf/S0092-8674(23)00740-7.pdf

posted on 12/03/2023 10:17 PM

2023/11/20JC (Ishikawa)

The projection-specific signals that establish
functionally segregated dopaminergic synapses

Cell 2023 Aug 31;186(18):3845-3861.Sarah Cheng. doi: 10.1016/j.cell.2023.07.023.

Akiko Terauchi, Patricia Yee,Erin M. Johnson-Venkatesh, David D.. Ginty, Wei-Chung A. Lee,Hisashi Umemori

posted on 11/20/2023 12:46 AM

2023/11/06 Journal Club (Yuzaki)

This time I will share the contents of A Symposium on Neuroscience of Dementia held in Singapore.。Especially one of the Keynote Lectures, Dr.. I would like to introduce some papers that are the basis for Hee-Sup Shin's lecture.。
Resumes will be distributed via Slack。

I will report on the proceedings of “A Symposium on the Neuroscience of Dementia,” which was recently held in Singapore. In particular, I will introduce the following two papers, on which the one of the keynote lectures by Dr. Hee-Sup Shin was based.
The resume will be distributed via Slack.

Key reference:
1.Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.
Kim SW, Kim M, Baek J, Latchoumane CF, Gangadharan G, Yoon Y, Kim DS, Lee JH, Shin HS.
Neuron.. 2023 Feb 1;111(3):418-429.e4. doi: 10.1016/j.neuron.2022.11.001.PMID: 36460007

2.A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse.
Keum S, Kim A, Shin JJ, Kim JH, Park J, Shin HS.
Neuron.. 2018 May 2;98(3):588-601.e5. doi: 10.1016/j.neuron.2018.03.041. PMID: 29681532

posted on 11/05/2023 4:35 PM

2023/10/16 Journal Club (M. Itoh)

A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors.

With Boudkkazi, swivel J, Nakaya N, Brechet A, colleague A, Harada H, Bildel W,

Kulik A, Dong L, Sultana A, Zolles G, Schulte U, Tomarev S, Torches B.

Neuron.. 2023 Aug 16;111(16):2544-2556.e9,,ar,j.neuron.2017.06.029,,en,Chai H,,en,Diaz-Castro B,,es,Shigetomi E,,ja,And Monte,,it,Octeau JC,,en,Cohn W,,en,Rajendran PS,,en,Vondriska TM,,ar,Whitelegge JP,,en,Coppola G,,es,Khakh BS,,bg,Neural Circuit-Specialized Astrocytes,,en,Transcriptomic,,en,Proteomic,,en,Morphological,,en,and Functional Evidence,,en,See also Nature,,en,NEWS,,en,VIEWS,,en. doi: 10.1016/j.neuron.2023.07.013. PMID: 37591201

posted on 10/13/2023 5:19 PM

2023. 8. 28 Journal club (Arai)

Nat Commun. 2023 May 30;14(1):3113. doi: 10.1038/s41467-023-38854-2.

Afferent convergence to a shared population of interneuron AMPA receptors

Reagan L Pennock, Luke T Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I Wadiche

PMID: 37253743

posted on 08/28/2023 8:22 AM