Translation

Welcome to Yuzaki Lab

・柚﨑研は慶應義塾大学 ヒト生物学-微生物叢-量子計算研究センター(WPI-Bio2Q)に移動しました。

・中枢神経系に加えて、末梢・自律・腸管神経系でのシナプス形成機構に焦点をあて、神経系と多臓器の連関機構やその破綻による病態の解明と治療法の開発を目指します。

Past News

Journal Club

9/12/2016 Journal Club (Otsuka)

Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD

Cell. 2016 Jul 14;166(2):299-313

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs

 

 

posted on 09/09/2016 9:53 PM

9/5/2016 Journal Club (Takeo)

Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY.

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.

 

 

posted on 09/02/2016 2:16 PM

8/29/2016 Journal Club (Yuzaki)

Oh WC, Lutzu S, Castillo PE, Kwon HB.
De novo synaptogenesis induced by GABA in the developing mouse cortex.
Science. 2016 Aug 11. [Epub ahead of print] PubMed PMID: 27516412

posted on 08/28/2016 6:09 PM

8/8/2016 Journal Club (Suzuki)

Ai-Hui Tang, Haiwen Chen, Tuo P. Li, Sarah R. Metzbower, Harold D. MacGillavr  & Thomas A. Blanpied

Nature(2016)doi:10.1038/nature19058

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

posted on 08/04/2016 8:07 AM

8/1/2016 Journal Club (Miura)

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM

Yan Zhao, Shanshuang Chen, Craig Yoshioka, Isabelle Baconguis & Eric Gouaux

Nature (2016) doi:10.1038/nature18961

 

(参考)

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy

Edward C. Twomey1,2, Maria V. Yelshanskaya1, Robert A. Grassucci1,4, Joachim Frank1,3,4,*, Alexander I. Sobolevsky1,*

Science 01 Jul 2016: Vol. 353, Issue 6294, pp. 83-86

posted on 07/29/2016 12:18 PM

journal,20160725(ibata)

Hemi-fused structure mediates and controls fusion and fission in live cells
Wei-Dong Zhao,
Edaeni Hamid, Wonchul Shin, Peter J. Wen, Evan S. Krystofiak, Seth A. Villarreal, Hsueh-Cheng Chiang, Bechara Kachar & Ling-Gang Wu

posted on 07/24/2016 5:26 PM

7/11/2016 Journal Club (Nozawa)

Feng Gao, Xiao Z Shen, Feng Jiang, Yongqiang Wu, Chunyu Han.

DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

Nature Biotechnology 2016 May 2.

doi: 10.1038/nbt.3547. [Epub ahead of print]

 

posted on 07/08/2016 6:55 PM

7/4/2016 Journal Club (Aimi)

Lrp4 in astrocytes modulates glutamatergic transmission.

Nature Neuroscience(2016)doi:10.1038/nn.4326

Sun XD, Li L, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, Mei L.

Published online 13 June 2016

http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4326.html

posted on 07/01/2016 8:53 PM

6/20/2016 Journal Club (Kono)

Weilinger et al., Nat Neurosci (2016) 19, 432

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity.

posted on 06/17/2016 8:24 PM

6/9/2016 Journal Club (Arai)

Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation.

Boyce et al., Science  13 May 2016: Vol. 352, Issue 6287, pp. 812-816

posted on 06/05/2016 9:11 PM

5/30/2016 Journal Club (Otsuka)

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Dheeraj S. Roy , Autumn Arons , teryn I. Mitchell , Michele Pignatelli , tomás J. Ryan  & Susumu tonegawa

Nature531,508–512(24 March 2016)doi:10.1038/nature17172

posted on 05/28/2016 12:25 AM

5/16/2016 Journal Club (Takeo)

Lisa Traunmüller, Andrea M. Gomez, Thi-Minh Nguyen, Peter Scheiffele

Control of neuronal synapse specification by a highly dedicated alternative splicing program

Science 12 May 2016 (published online ahead of print)

DOI: 10.1126/science.aaf2397

posted on 05/15/2016 12:16 PM