A critical role for microglia in regulating metabolic homeostasis and neural repair after spinal cord injury

Huan Jian, Kailin Wu, Yigang Lv, Jiawei Du, Mengfan Hou, Chi Zhang, Jianqing Gao, Hengxing Zhou, Shiqing Feng

Free Radical Biology and Medicine, 20 November 2024, Volume 225, 469-481
DOI: 10.1016/j.freeradbiomed.2024.10.288

This Journal Club examines how microglia shape the tissue environment for repair after spinal cord injury. The study shows that microglial depletion disrupts lipid metabolism, increases neuronal oxidative stress, and impairs motor recovery.
The discussion focuses on the protective functions of microglia in maintaining metabolic homeostasis, highlighting how preserving these functions could complement strategies aimed at promoting neural regeneration and rebuilding functional connections.

11/04/2026 11:34 AM | Journal Club