Dr. Yuzaki participated and gave a talk at the NUS-Keio Joint Symposium at the National University of Singapore on January 10-11th, 2017. See photos.

Symposium held at the "brain circuit creation of Elucidation and control technology of the formation and operation principle of the forefront 2017- brain circuit of research" is January 20 (Friday) 10:00 30 minutes to Conference Square M (Marunouchi Mitsubishi building 10F) willTodid。This symposium by eight research team that has been adopted in AMED-CREST research expenses。People Ya, which is engaged in the life science and medical research、Planning is that target to the general public who are interested in the mechanism of the brain。Alone with participation tightening is up to 13 days。Click here for detailsUntil。

Otsuka-kun’s thesis paper has been published in J Neurosci. This work was done in collaboration with Dr. Konno (co-first author) in Prof. Watanabe’s laboratory and Dr. Abe in Prof. Sakimura’s laboratory. It was featured as “It has been featured in "This Week in The Journal." .”

 Dr. Yuzaki gave a talk at The 47th NIPS International Symposium “Decoding Synapses,” held at the National Institute of Physiological Science on October 26-28, 2016.

Prof. Yuzaki gave a talk at the OIST mini-symposium/the Core-to-Core program of JSPS, entitled “Nanoscale mechanisms of synaptic functions,” which was held on September 25- 27 at Okinawa. Other speakers include: Larry Trussell, Robert Edwards, Volker Hauck, Nils Brose, If Kavalalı, Ian Forsythe, Peter Jonas, Stephan Sigrist, Reinhard Jahn,Ryuichi Shigemoto, Stephan Hallermann, Alan Marty, Tobias Moser, Ko Matsui, Hiroaki Misonou, Haruhiko Bito, Shinya Kawaguchi, Toshihisa Otsuka, Sumiko Mochida and Tomoyuki Takahashi.

A review for general readers"Science in Keio University School of Medicine"A review of Keiko Matsuda lecturer was published in the。

A new group grantIn the "dynamic control of brain function due to scrap and build" Kakenhi new academic area studies、As kick-off symposium and public research briefing the following will be heldYou。、It ended on a high note。
Date and time：2016On September 8 (wood) 13:00-17:00
Meeting place：The University of Tokyo Faculty of Science, Building No. 1 Koshiba Hall
http://www.u-tokyo.ac.jp/campusmap/cam01_00_25_j.html

For more details, until the Grants-in-Aid for Scientific Research Scientific Research on Innovative Areas "dynamic control of by the scrap-and-build brain function."。
http://www.scrapandbuild.bs.s.u-tokyo.ac.jp/

A new paper, based on collaboration with Dr. Arisesuku's lab at Oxford University, 7has been published in Science on July 15th..。In this research、It is a joint of nerve cells and nerve cells to reveal the structure of the bridge that connects the "synapse"、Nerve cells in conjunction with each other was to elucidate the new mechanisms regulating neural network function。The results of this research”It was featured in the "This week in Science“But it was introduced as "Transmitting signals across the synapse (signal beyond the synapse)."。

In the synapse、Glutamate is released from presynaptic、Excitement to the next nerve cell is transmitted by binding to the glutamate receptor of postsynaptic。Furthermore, from presynaptic、It has been revealed in our laboratory that the group of molecules similar to "complement" of the immune system be released to adjust the synaptic function so far。However、And excitement transmission path through the glutamic acid、How to work and how synaptic regulatory pathways by complement family molecules did not know well。

In small brain circuit、Presynaptic releases complement family molecules referred to as CB El N. 1 (Cbln1)、And then binds to a receptor that neurexins (Nrx) present in the presynaptic。On the other hand、Cbln1 will cause the synapse formed by combining at the same time also to the postsynaptic delta type 2 glutamate receptor (GluD2)。Nozawa-kun, together with Hayashi-san、Nrx-Cbln1-GluD2 the structure of the three-party complex that was the first time Tokiakasa。as a result、Cbln1 not only serve to anchor the presynaptic and postsynaptic as adhesive、By adjusting the working styles itself postsynaptic GluD2 the subtle、It was found to control the happened ease of excitement transmission in the synapse (= memory and learning process)。

Complement family molecules · Nrx · glutamate receptors are also present in various brain regions other than the cerebellum。Therefore、This was revealed、Functional regulation mechanism of glutamate receptors by complement family molecules are expected to be working as well in a variety of neural circuits。

Glutamate receptors conformation of the ligand binding site will change by the binding of glutamate。It introduced two His residues to the appropriate site of the ligand binding site、By varying the conformation by Pd molecules administration、Methods of modulating artificially activated, inactivation of ionotropic and metabotropic glutamate receptors has been developed。In this study of the Qing in Kubota teacher of Ken Kyoto University Hamachi your job、6A month 28 daysAOP in Nature Chemistry magazineIt was published as。Yuzusakiken has participated as CREST sharing research。

In this laboratory、With the expansion of the promotion and research of predecessor、Newly started the recruitment of assistant professors 1-2 people。In response to this until the experience、Depending on the qualification, we considereitherIt expects to。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

There is interest in these areas、If it is aimed at the future of the step-up、I'd love to、１）CV、 2) Research proposal、3) Two references (name and contact information)Writing、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。Thank you for a lot of applicants。

Keiko Matsuda lecturer and Tim Budisantoso kun is first author of the paper4Online version of Neuron of the month 28 days.。

Kainate receptors of the glutamate receptor、There was particularly high in specific synapses of the hippocampus, an important brain region in memory and learning、The transmission rate that is slow not to other receptors、And the essential role in the integration of hippocampal neural network activity。However、Whether incorporated only to certain synaptic kainate receptors what mechanism、The mechanism was not well understood。In this paper, the、By neurons secrete proteins called the C1ql2 and C1ql3、I found that coming to collect the kainate receptors directly。Also、In the hippocampus of mice lacking the C1ql2 and C1ql3、Kainate receptors is not incorporated into the synapse、Be less likely to occur epileptic seizures was found be given a stimulus to induce epileptic artificially。

C1ql2、C1ql3 is also present in various brain regions、Are considered each by controlling the built-in and function of kainate receptor synaptic neural make up the appropriate neural network activity。The results of this research、It is expected to be of use in the therapy method development and cause elucidation of epilepsy and autism。

This paper、As this month's attention paper of Neuron magazinePreview “Synaptic Menage a Trois”Was introduced as (ThreesomesPlease check out our own meaning of。）

Koda, Associate Prof. promotion as St. Marianna University School of Medicine Department of Physiology professor from April 1。1996St. Jude (but was back in the temporary Tokyo University psychiatry in the middle) Children's Research yuzu Saki Institute at the hospital since joined as the first post-doc at the time of the birth is the beginnings of the oldest founding life member in year。I wish more and more of your success future。

4It belated celebration meeting a month 15 days (farewell party) at the Art Complex。As Koda teacher himself Violin player、Miura (Violin)、Nozawa Jun (Viola)、Great string quartet by Takeo's (Cello) have been made。Photos here→