131st Brain Club was to welcome the Iino Masamitsu teacher (Nihon University School of Medicine) carried out under the heading of "physiological and pathological conditions of the central nervous system to explore with calcium imaging"。

75th Fujiwara Symposium (The Cerebellum as a CNS Hub) is、12From one day a month of 4 days、It was held at the Tokyo Medical and Dental University。Mizusawa Professor、Ken Professor as organizer、Timothy from abroad Ebner, Michael Hausser, Germund Hesslow, Hong Jiang, Sheng-Han Kuo, Phil Hyu Lee, Stephen Lisberger, Mario Manto, Javier Medina, Chris Miall, Christopher Person, Stefan Plust, Jennifer Raymond, Jeremy Schmahmann, Reza Shadmehr, John Simpson, Peter Strickland, Catherine Stoodley, Bing-Wen Soong, Peter Their, Dagmar Timmann, Jan Voogt, Chris De Zeeuw、It is an international symposium that led to the cerebellum researchers 30 people coming further from Japan。Is the father of the cerebellum study of the 90 th birthday of Masao Ito teacher celebration was also serves as。PhotoHere →

Ishida lecturer has been adopted in the pharmaceutical Foundation research expenses Kanae。

It gave a celebration meeting of Gakushin DC graduate of conference-kun and Nozawa-kun。Congrats!

J Physiology (London)PhD 4 years of the magazineKono's thesisIt came out。
It is well known that the expression of LTP and LTD, which is considered as the basis for processes of memory NMDA receptor (NMDA receptor) is essential。In the previous study、In the important cerebellum to the motor learning、NMDA receptor had been shown to be required for the expression of LTD and LTP。But almost no NMDA receptor expression in the cerebellar Purkinje cells after mature。 paper、NMDA receptors expressed together which cells、How do you control the LTP / LTD? In this paper、Purkinje cells、Granulosa cells、We were challenged with this problem by deficient NMDA receptor gene in each intervening neurons。

Muscle fibers are created by the fusion of myoblasts。Fusion of myoblasts happened even during muscle regeneration after damage, not only during development、It has been strictly controlled。We've discovered as a molecule to control the strengthening and pruning of climbing fibers of the cerebellum so far BAI3 is、Although the muscle fibers to be involved in the fusion of myoblasts had been shown so far、The detailed molecular mechanism was not well understood。In this paper、C1qL4 suppresses the BAI3、Stabilin-2 has revealed that temporally and spatially controlled fusion of myoblasts by activating (→ paper is here.）。Synapse formation is C1qL1-BAI3 in the cerebellum、In the muscle it is extremely interesting that C1qL4-BAI3 to control the muscle formation。As a joint research with Canada's Jean-François Côté laboratory、Conference and Kakegawa, Associate Professor of short-term come the Viviane Tran's a graduate student was indebted to Keio。

River Iwasaki Hiroshi teacher(Kanazawa University of Medicine, Neurosurgery, School of Medicine,)The 130 times Brain Club due to have been made。The title is "analysis of the cerebral cortex formation mechanism using the mouse and ferret"。

On this occasion、For the development of JST ERATO Keio University bases ( "neuro molecular techniques", Kyoto University Hamachi Summary - 2018- 2024) (representative, Kakegawa)、We are looking for new Fellow in the (engineer)。

In this ERATO study、By the creation of chemical biology molecular techniques、The changes in the synapses associated with neuronal activity and memory and learning、And elucidation at the individual protein molecule level。As a result、Changes in the synapses in normal and psychiatric and neurological disorders pathology elucidated at the molecular level、We aim that will lead to new treatment and diagnostic technology。Close collaboration will be required of the Kyoto base for this purpose (bio-organic chemistry and supramolecular chemistry) and Keio base (neuroscience)。

As the business of the special researcher、As Keio base of this studyAdministrative and public relationsWith、Research SupportIt will be carried out。
(1) those who want to try to participate in the Keio base as a member of the research team
(2)Those who have a sense of responsibility and cooperative spirit
(3) If there is a research experience and laboratory work experience (desirable but not required)
Please apply all means。

If you are interested, please prepare 1) CV with、2) 2 people Reference destination (name and contact information)、3)Preferred interview date、and contact Lab Secretaries (hirayama@keio.jp, yuri.y@keio.jp) to Please apply。For further questions, please contact them, too.。.、Please note that Application documents should not be returned。Payroll will be determined according to the University rules。The recruitment will be closed as soon as personnel are found。It was closed。

On this occasion、Conference-kun of the graduate students of this laboratory (D3)And Nozawa-kun (D1)Each but、Japan Society for the Promotion of Science Research Fellow (DC)It became a pre - approved in。Congratulations!。

Yuzusaki reblogged Talk in place the Cold Spring Harbor Asia symposium in Awaji Island。Conference (D3)And Nozawa (D1)Each also、I gave a poster presentation。

Development process of the dendrites of nerve cells are not fully reproduced in the in vitro。For example, juvenile type of neurites but will be trimmed once in the in vivo、This behavior does not know the mechanism may not be observed in in vitro。In this study by observing neurite development process in in vivo by performing intrauterine electroporation、It was revealed that Caveolin-1 controls the development process of dendrites via endocytosis of N- cadherin and L1。It is the job of when the Sendai's has been stayed's with Shikanai to yuzu Saki Research。Paper is here →

Activity-dependent endocytosis of AMPA receptors at postsynaptic sites、which underlies long-term depression (LTD), is thought to mediate certain forms of learning and memory in vivo。However、whether LTD at synaptic levels is causally related to learning and memory at system levels has remained unclear。In thisNeuron paper、using a new optogenetic tool, termed PhotonSABER, which could acutely and reversibly inhibit LTD in a light-dependent manner、we show that LTD at parallel fiber-Purkinje cell synapses、is essential for eye movement-based motor learning in vivo。Dr. Kakegawa, Associate Professor at Keio University、and Dr. Matsuda, Associate Professor at the University of Electro-Communications、performed all experiments with great helps from Dr. Kato, Associate Professor (Tokai Univ.), Dr. Fukasawa, Professor (Fukui Univ) and Dr. Kohda, Professor (St. Mali University School of Medicine)。

TheVideo Abstract has been published in Neuron.。YouTube is here.→。