Ibata's paper、In Neuron magazine May 6, online version (US Eastern time 11:00).。Protein Cbln1 which has a function to create a new synapses、That is secreted from the lysosomes of nerve cells in response to neuronal activity、This study, which was revealed by the experiments using a mouse。
Lysosomes is、A cell organelles with enzymes that break down proteins、It plays a decomposition of no longer needed intracellular protein。Cbln1 was found to be present in the lysosome in the axons of nerve cells by this time of the study。Also, when the neural activity is enhanced、The contents of the lysosomes from axons that (a proteolytic enzyme and Cbln1) are both secreted out of the cells was found for the first time。From these experimental results、Destruction and synapse formation by Cbln1 extracellular environment by proteolytic enzymes、By working in concert、Possibility that the restructuring takes place in the synapse in response to neural activity is suggested。Synaptic reorganization is an entity of memory and learning、The failure have been reported in a number of mental illnesses and neurodevelopmental disorder、The results of this research are expected to lead to the development of understanding and new treatments for the normal development mechanism and these conditions。
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Suzuki KuniMichisuke Christian papers of (Adjunct)Frontiers in Neurosci誌.。As part of its international activities support business Young Glia of the new academic area (glial assembly) is the result of joint research with Alexander Ditytatev Institute of Germany DZNE。Suzuki-kun is co-first author。Congratulations!。

135th Brain Club was held titled "dementia and the prion-like propagation" to welcome the Naruhito Hasegawa teacher (Tokyo Medical Research Institute, dementia, higher brain function research field)。

Brain Bee (Brain Science Olympics)Japan representative candidate 4 people came to visit the laboratory。1After the time of the lecture、I was eager to learn to slow down the training, such as an electrical recording by the patch-clamp technique in the prism adaptation and brain sections。

Brain Bee is in the event that the NPO "the century of the brain" is performed in order to foster the next generation to learn the brain science、Japan Neuroscience Society and JapanBrain Science Society of AssociationThere has sponsored。northeast·Shikoku medium andKyushu, Kanto, the four people who won the district of qualifying Kansai Japan representative candidates will head to the world tournament after this。Also7Japan Neuroscience Society of the monthAlso done award ceremony at。

134th Brain Club is Matthew P. Mr. Anderson (Harvard Medical School)Welcomed Shi、It was held titled "Mapping the Circuits that Control Aggression via Autism Gene Convergence"。

133rd Brain Club is Shi welcomed Haruhiko Shiomi teacher (Keio University School of Medicine molecular biology classroom)、It was held titled "De novo DNA methylation and chromatin architecture during mouse gonocyte" (methylation and chromatin structure of DNA in the mouse Gore Roh site)。

Kono-san's doctoral paper、which was published in the Journal of Physiology, was featured in Perspective.。According to the comment, ”These results by Kono et al. (2019) represent a major step forward to cut the Gordian knot regarding the precise subcellular localization of NMDARs in the cerebellar microcircuitry and the cellular mechanism of PF–CF signal integration”.、They also describe that this paper represents a major step to fully understand where and how NMDA receptors function in the cerebellar circuit。The expression "cut the Gordian knot"、means "put an end to a long-standing question in an unexpected way."。Since it was tied by Gordius King、nobody was able to untie it (the Gordian knot)、when the Alexander the Great cut the knot by the sword。

Kaichi as part of the "quest activities" of high school、1Grade of Omino Mr.、3 people's Seino has been come to yuzu Saki Research。After a brief lecture、It gave a enthusiastic question and answer session with the laboratory tour。I hope you went interested in neuroscience even a little to the people of the next generation。

Hokkaido University of Education University Hakodate junior high school sophomore Maeda Mr.、Igarashi-kun、Machiya-kun of 3 people、It came to yuzu Saki Research as part of the graduation study。After a brief lecture、It gave a enthusiastic question and answer session with the laboratory tour。I hope you go interested in the future even a little neuroscience。

The UK Medical Research Council (MRC: Based Medical Research Council) and the MOC (memorandum of understanding on cooperation) of Japan medical research and development mechanism (AMED)、Following the open day English neuroscience symposium last year in London、The second meeting was held in the dates of February 9-11 days in Chiba Prefecture Kisarazu of Kazusa Academia Hall。Yuzusaki has participated as an organizer from AMED side。

132nd Brain Club has been done to welcome the Atsushi Yamagata teacher (University of Tokyo quantitative Institute of Life Sciences tip quantitative life science research departments) entitled "infrastructure of control by selective splicing and complex formation of synaptic organizer" It was。

Yuzusaki isSeminar at Nagoya University Research Institute of Environmental Medicine,It gave a (Medicine Advanced Course)。”Getting started of new synapses (and break the way)How to Construct and Deconstruct Synapses”It is titled。We had a good time to interact with many of the young researchers, including the mountains (Akihiro) Research and Ken Osakada。