The 161st Brain Club welcomed Dr. Takero Saneyoshi (Kyoto University)。The title of the presentation was ``Cofilin inside the dendritic spine exhibits molecular activity through liquid-liquid phase separation."forming a sexual gradient"。Long-term potentiation (LTP) is considered a fundamental process of memory learning.) paper、Structural changes occur in which dendritic spines become larger over time, but the mechanism was not fully understood.。Dr. Saneyoshi found that the temporarily increased Ca concentration within the spine、Continuously activates calmodulin kinase (CaMKII) and its downstream enzymes.、As a result, the mechanism that changes the actin skeleton has been successfully clarified.。We all listened with great interest.。

The projection-specific signals that establish
functionally segregated dopaminergic synapses

Cell 2023 Aug 31;186(18):3845-3861.Sarah Cheng. doi: 10.1016/j.cell.2023.07.023.

Akiko Terauchi, Patricia Yee,Erin M. Johnson-Venkatesh, David D.. Ginty, Wei-Chung A. Lee,Hisashi Umemori

This time I will share the contents of A Symposium on Neuroscience of Dementia held in Singapore.。Especially one of the Keynote Lectures, Dr.. I would like to introduce some papers that are the basis for Hee-Sup Shin's lecture.。
Resumes will be distributed via Slack。

I will report on the proceedings of “A Symposium on the Neuroscience of Dementia,” which was recently held in Singapore. In particular, I will introduce the following two papers, on which the one of the keynote lectures by Dr. Hee-Sup Shin was based.
The resume will be distributed via Slack.

Key reference:
１．Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.
Kim SW, Kim M, Baek J, Latchoumane CF, Gangadharan G, Yoon Y, Kim DS, Lee JH, Shin HS.
Neuron.. 2023 Feb 1;111(3):418-429.e4. doi: 10.1016/j.neuron.2022.11.001.PMID: 36460007

２．A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse.
Keum S, Kim A, Shin JJ, Kim JH, Park J, Shin HS.
Neuron.. 2018 May 2;98(3):588-601.e5. doi: 10.1016/j.neuron.2018.03.041. PMID: 29681532

Yuzaki will enjoy the honor of receiving the Medal with Purple Ribbon in the fall of 2023.。The Purple Ribbon Medal、Inventions and discoveries in the fields of science and technology、This is a badge of honor given by the country to people who have made outstanding achievements in academics, sports, and the arts.。The transmission ceremony and audience were held on November 13th.。The photo shows Machi Tawara representing the recipients at the ceremony.。This award was given in recognition of my achievements in the field of neuroscience.、of course、I would like to thank all the staff, postdocs, graduate students, technicians, secretaries, and many co-researchers who have worked with me thus far.。I am grateful for the congratulatory telegrams and emails I received from many people.。

10Held in Singapore on March 30th-31st、”A symposium on Neuroscience of Dementia“attended、Yuzaki gave a Keynote lecture。Another Keynote lecturer was Professor Hee-Sup Shin from South Korea.。This symposium is a group study similar to AMED in Japan.、It was the culmination of five and a half years of major grant research into dementia led by Professor George Augustine of Lee Kong Chian School of Medicine.。Additionally, on October 31st, Duke-NUS (National University of Sigapore)、We held a seminar。This was at the invitation of Mr. Nishiyama, who graduated from Yuzaki Lab and is independent at Duke=NUS (Photos here）。