Ms. DILINA Tuerde、JSPS Special Fellow for Foreigners(PD)Adopted by。Congratulations!。For outstanding young researchers from other countries who have just obtained their Ph.D.、This program provides opportunities to engage in research at Japanese universities and other research institutes.。Only 8 people in all of Japan are employed in biological sciences.。

Nature 609: 374–380. Published online 13 July 2022
Dopamine subsystems that track internal states.
Grove JCR, Gray LA, The Holy Medina N, Sivakumar N, Ahn JS, Body TV, Berke JD, Kreitzer AC, Knight ZA
DOI: 10.1038/s41586-022-04954-0

4th year doctoral student Kazuya Nozawa's dissertationOnline version of Neuron.。For Press releaseClick here. 2022。
by improving Expansion Microscopy (ExM), a high-resolution microscopy technique、Molecules that determine the individuality of synapses in the brain at the nano level (one millionth of a millimeter is one nanometer)：nm) revealed the structure of。

The neural network that underpins the functioning of the brain、Nerve cells are connected to each other by synapses。Various molecules that connect synapses are、Because it is concentrated in a narrow region of about 100 to 1000 nm in the synapse、Its detailed distribution cannot be observed with the resolution of conventional optical microscopes (approximately 200 nm).。there、Nozawa-kun, together with Hayashi-san、We further improved ExM, a technology that expands the specimen itself to about 1000 times its volume.、By optimizing for synaptic observation、For the first time, we succeeded in clarifying the structure and interrelationships of molecular groups that connect excitatory synapses in mouse neural networks at the nano-level.。According to the comment, 、A group of synaptic molecules that bind to neurexin (neurexin ligand)、It was discovered that they accumulate as units of ``nanodomains'' of several tens of nanometers each within synapses.。further、Depending on the type of neurexin present at the presynaptic site、It has been found that the arrangement of nanodomains of post-synaptic synaptic molecules and glutamate receptors is determined。
From the results of this research、The characteristics of synapses that support brain function、It turns out that each specialized synaptic molecule is created by interacting at the nano level.。These molecular groups have been reported to be associated with many psychiatric disorders and neurodevelopmental disorders.、It is expected that the results of this research will lead to an understanding of the pathogenesis of these diseases and the developmental mechanisms of normal neural circuits.。Taku Sogabe, a fifth-year medical student, also contributed greatly to the development of ExM.。

The 151st BrainClub presenters include:、We invited Dr. Takuya Sasaki from the Graduate School of Pharmaceutical Sciences, Tohoku University (Friday, July 15, 2022).、Face-to-face and web hybrid format)。heavy rain、Welcome to Keio University、He gave a lecture titled "Operating Principles of the Hippocampal Circuit Controlling Learning and Memory".。from the hippocampus and related brain regionsin vivoCan be deciphered from analysis results using multi-unit recording、Changes in neural activity during individual learning and memory、He talked about the research results obtained so far.。Also、Please also make a presentation on a new attempt to expand the recording target beyond the brain with the latest knowledge.、Lively discussions took place。

The photo is a commemorative photo taken after the lecture。Sasaki-sensei is in the center back row。Yuzusaki lab has many electrophysiology members。* There is no deep meaning in blurring the background (automatic adjustment of a certain Google smartphone used for trial)。After all, clean up a little ry (conference)

Assistant Professor Takano received the Young Investigator Award from Keio University School of Medicine in the 4th year of Reiwa.。Congratulations!

bioRxiv.  Posted May 29, 2022.

Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

V. C. Wong, P.R. Houlihan, H. Liu, D. They passed by, M.C. DeSantis, Z. Liu, and E. C. O’Shea

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147

doi: https://doi.org/10.1101/2022.05.29.493906

This article is a preprint and has not been certified by peer review.

※Paper printing"not recommended"

The following treatises will be introduced at JC next Monday.。Which L, et al., Neuron.. 2022 Mar 2;110(5):809-823.e5.
Glutamate in primary afferents is required for itch transmission.
PMID: 34986325 doi: 10.1016/j.neuron.2021.12.007. Epub 2022 Jan 4. Thank you.。

https://pubmed.ncbi.nlm.nih.gov/34986325/

Cutando et al., Nature Neuroscience (2022) June 16 online

Cerebellar dopamine D2 receptors regulate social behaviors.

PMID: 35710984 DOI: 10.1038/s41593-022-01092-8

(If you cannot return due to the influence of the Okinawa typhoon、Including whether or not it is implemented、Please let consultation。）

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
Simon Bossi 1, Dhanasak Dhanasobhon 2, Graham C R Ellis-Davies 3, Jimena Frontera 1, Marcel de Brito Van Velze 2, Joana Lourenço 2, Alvaro Murillo 4, Rafael Lujan 4, Married Mariano 1, Isabel Perez-Otano 5, Alberto Bacci 2, Daniela Popa 1, Pierre Paoletti 6, Nelson Rebola 7
Neuron. 2022 June 10;S0896-6273(22)00457-3.

doi: 10.1016/j.neuron.2022.05.016. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

To understand how neural circuits in the brain work、There is a need for technology that selectively activates glutamate receptors, which are neurotransmitter receptors that control memory and learning.。In this research、While maintaining the original glutamate response ability、Developed a mutant glutamate receptor (metabolized type) activated by an artificial compound。We created mice that actually expressed this artificial glutamate receptor in a specific cell type.、It was shown that the administration of artificial compounds activates metabotropic glutamate receptors in a cell-type selective manner.。It is expected that the understanding of neural circuits will be accelerated by using this new technology "coordination chemogenetics method".。This research was supported by ERATO / CREST, Nagoya University Kiyonaka Lab.、This is a joint research with Kyoto University Hamaji Lab.。Click here for the paper

Emergent reliability in sensory cortical coding and inter-area communication
Sadegh Ebrahimi 1 2 3 4, Jerome Lecoq 5 6 7 8, Oleg Rumyantsev 5 6 9, Tugce Tasci 5 6 10, Yanping Zhang 5 6 11, Cristina Irimia 5 6 7, Jane Li 5 7, Surya Ganguli 5 9,

2022 May;605(7911):713-721.
doi: 10.1038/s41586-022-04724-y. Epub 2022 May 19.