Dr. Teruhiro Okuyama of the Institute for Quantitative Life Sciences, The University of Tokyo, visited us.、The 152nd BrainClub was held (12/23(Fri) 16:00~17:30）。The title of his presentation was "Neural Mechanisms of Social Memory in the Hippocampus"。How "social memory" is processed as information in the ventral hippocampus、Obtained using calcium imaging and optogenetics、He gave a lecture on the results of his research to date.。In addition, please introduce the latest data on the brain representation mechanism of life and death.、It was a lively time for discussion from beginning to end.、I thought it was good too.)。

The photo above is the usual after the lecture、Commemorative photo while holding my breath @Yuzuzaki Laboratory。Okuyama-sensei is next to Yuzuzaki-sensei.。I'll do my best to clean up~ Aye oh…(Press conference)

Small molecules administered to adults、As a new technology that visualizes how and where in the brain it is distributed like a snapshot、We have developed a method for immobilizing small molecules using paraformaldehyde, which is often used in tissue fixation.。by this method、metabotropic glutamate receptor mGlu1、AMPA-type glutamate receptor、Succeeded in visualizing the localization pattern of dopamine receptors after ligand administration。This research was supported by ERATO/CREST.、In collaboration with Nagoya University Seichu Lab、published in Chemit was done。

Synaptic pruning through glial synapse engulfment upon motor learning

Yosuke M.. Morizawa, Mami Matsumoto, Yuka Nakashima, Narumi Endo, Tomomi Aida, Hiroshi Ishikane, Kaoru Beppu, Satoru Morito, Hitoshi Inada, Noriko Osumi, Eiji Shigetomi, Schuichi Koizumi, guangyang, Hirokazu Hirai, Kohichi Tanaka, Kenji F.. Tanaka, Nobuhiko Ohno, Yugo Fukazawa & Ko Matsui., Nature Neuroscience, Nov;25(11):1458-1469. (2022)

doi: 10.1038/s41593-022-01184-5.

PMID: 36319770

Science Digest、Human Frontier Science Program (HFSP)is a new publication of。In HFSP-supported research、The most notable scientific achievements are highlighted。Commemorative first issue was published、We are the German Center for Neurodegenerative Diseases(DZNE)of Alexander Dityatev Laboratory、I was informed that the research I conducted with Dr. Radu Aricescu, Oxford University (at that time) has been published.。
HFSP home pagecan be read at。Also、excerpt isfrom hereavailable for download。

Goal 7 of the moonshot research and development project, "Understanding and application of intestinal bacterial action principle for extending healthy life expectancy" was adopted.、A kick-off meeting was held this time。Professor Kenya Honda is the project manager (PM))Is the、Yuzuzaki will participate as PM assistant and team leader of the "gut-brain linkage analysis team"。2022It is a research and development project for 6 years from FY 2019 (up to 9 years until FY 2030).。

Programmable RNA sensing for cell monitoring and manipulation

Yongjun Qian, Jiayun Li, Shengli Zhao, Elizabeth A Matthews, Michael Adoff, Weixin Zhong, Xu An, Michelle Yeo, Christine Park, Xiaolu Yang, Bor-Shuen Wang, Derek G Southwell, Z Josh Huang.

Nature 2022 Oct;610(7933):713-721. doi: 10.1038/s41586-022-05280-1. Epub 2022 Oct 5.

PMID: 36198803

Workshop 2022 was held to improve Presentation Skills。

Presentation skills for researchers、In addition to presenting research results and interacting with other researchers,、Returning research results to the general public、It is an essential technology when acquiring research funds。As an active brain science researcher,、Lectures and practical training were given by Professor George Augustine, who has a proven track record in teaching presentation methods.。
Graduate students belonging to Keio University Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, and Graduate School of Science and Engineering、Young researchers participated。

This program is a WPI (Bio2Q)It is scheduled to be held as one of the joint graduate school programs (STaMP) in。

*Click here for Lecture videos→Open to those who belong to Keio University。

※※Lecture and Workshophere (photo)

Neuron., Volume 110, Issue 9, 2022, Pages 1532-1546.e4.

Differential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio

Mathieu Lafourcade, Marie-Sophie H. van der Goes, Dimitra Vardalaki, Norma J. Brown, Jakob Voigts, Dae Hee Yun, Minyoung E. Kim, Taeyun Ku, Mark T. Harnett

¹Department of Brain & Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

²Department of Brain & Cognitive Sciences, Picower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

doi: 10.1016/j.neuron.2022.01.025

Japan-U.S. brain. Brain Research Cooperative Program) and Core-to-Core Program supported symposium Development and Plasticity of the Brain was held in Ise-Shima between October 21st and 23rd。This meeting also commemorates the retirement of Professor Nobuhiko Yamamoto.。From the laboratory, Nozawa and Yuzu participated and Nozawa gave an oral presentation in English.。Photos from the symposiumClick here. 。

The 15th ChemBio Lecture hosted by the Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo was held on September 28 at Hongo Campus.、Yuzuzaki<gave a lecture。Another speaker is Professor Makoto Arita (Keio/RIKEN)、Associate Professor Ayumi Ishii (Teikyo University of Science)、Associate Professor Hiroshi Inaba (Tottori University)、It was Professor Hirohisa Omiya (Kyoto University)。

9The 4th event was held in Karuizawa from 19th to 22nd of the month. UK-At the Japan Neuroscience Symposium (sponsored by AMED-MRC)、Ms. Shiozaki, a graduate student, was selected for the best poster award。One presentation from Japan、One topic will be selected from the UK side.、The supplementary prize is the next 5th held in the UK UK-Invitation to oral presentation at Japan Neuroscience Symposium (travel expenses included)。Congratulations!