The ``Seminar for Exchange of Opinions in the Field of Brain Research'', a Japan-US science and technology cooperation project, has been held since 2000 based on an MOU between the US and Japanese governments.、2026Held at Rihga Royal Hotel Osaka from June 15th to 16th。

This year's theme is "Convergence of RNA Processing Alterations and Synaptic and Neuronal Dysfunction in Neurodegeneration."、Starford University Aaron Gitler on the US side、The Japanese side was organized by Professor Yuka Koike from Niigata University.。for 2 days、Pathological mechanisms of neurodegenerative diseases such as ALS and AD、There was a lively discussion from the perspective of RNA processing and synaptic disorders.。Professor Okano and Yuzaki participated from Keio University.。

Yuzaki was invited to the 68th Japanese Society of Child Neurology held in Utsunomiya on June 6th.、Special lecture "Psychiatric and neurological diseases and developmental disorders approaching through synapse research" was given.。

The 174th Brain Club was held on April 10th.。Lipid Regulation of Ion Channels in Neuronal Excitability: With the theme of Molecular and Structural Mechanisms.、The following two speakers spoke.
Dr. Yasushi Okamura （Specially Appointed Researcher, WPI-PRIMe, Osaka University）
Electrophysiological Analysis of Lipid Regulation of Inhibitory Neurotransmitter Receptors and K+ Channels
Dr. Radu Aricescu (Group Leader, MRC Laboratory of Molecular Biology, UK）
Structural Basis of Lipid Regulation of GABAA Receptors

The 173rd Brain Club was held on March 31st.。send、The following 4 from the UK, France, US, and BelgiumInviting famous researchersKishita Mini-symposium on “Symposium on Synapses: From Assembly to Receptor Mechanisms"is。

• Ingo Greger (MRC Laboratory of Molecular Biology, UK) “Relating AMPA receptor structure to function at the synapse”
• Joris de Wit (VIB Center for Brain & Disease Research, Belgium) “From proteins to circuits: defining pyramidal neuron input architecture and remodeling in disease”
• Pierre Paoletti (Institute of Biology of the ENS, France) “Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites”
• Yimin Zou (University of California, San Diego, USA) “Emerging Roles of Planar Cell Polarity in Assembly, Maintenance, and Function of Glutamatergic Synapses”

Yuzaki gave an oral presentation and Assistant Professor Thomas Chater gave a poster presentation at the 5th UK-Japan Neuroscience Symposium (sponsored by MRC-AMED) held at Jesus College, Cambridge University, UK.。Mr. Thomas won the Excellence Award.、Obtained invitation to the 6th Symposium。

The 172nd Brain Club was held on Friday, November 7th.。This time, Dr. Florian Levet (Quantitative Imaging of the Cell team),The Interdisciplinary Institute for Neuroscience in Bordeaux) was invited as a lecturer.。The title of the presentation was “Making Sense of Synaptic Organization”: From Super-Resolution Imaging to Multimodal and Multidimensional Analysis」です。Dr. Florian、Using single molecule localization microscopy (SMLM)、Revealing the existence of discrete nanodomains in synapses and、Established quantitative methods for analyzing protein configuration at the nanoscale。Currently、We particularly focus on developing a computational framework specialized for nanoscale neuroimaging data analysis.、further、Deep 3D imaging with adaptive optics + single objective light sheet (soSPIM)、High-content soSPIM pipeline for large-scale analysis of organoids/neurospheres、Correlation between molecular arrangement and morphology STED–PALM、He also talked about spectral SMLM, which identifies multiple proteins simultaneously.。I once again realized that this kind of computational scientific approach is essential in order to utilize advanced microscopy techniques in biological science and neuroscience.。

The 171st Brain Club was held on October 2, 2025, co-sponsored by WPI-BIo2Q. This time, Dr. Kiyonaka Shigeki (Professor, Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University；We welcomed the lecturer to the Institute for Quantum Chemical Innovation, the Future Society Creation Organization (Director of the Institute for Quantum Chemical Innovation).。The topic is "Visualization of native receptors and development of cell-selective regulation techniques for elucidating higher brain functions."。Dr. Kiyonaka and others、Towards elucidating brain function、Integrated in neurons and glial cellsWe are developing receptor visualization and regulation technologies。In particular, we provide a precise and quantitative solution to the dynamic changes of glutamate receptors, which hold the key to the molecular mechanisms of memory and learning.We were introduced to the chemical methodology for analyzing。Also、Existing chemogenetics are cell-controlledIn contrast to the resolution、Endogenous receptorsWe also talked about technology to increase the time resolution that corresponds to activation.。I was once again impressed by the magical chemical modifications and compound synthesis based on the structure of receptors.。We hope to continue to elucidate brain functions through collaborative research using new tools.。

The 170th Brain Club was held on September 3, 2025, co-hosted with WPI-BIo2Q. This time, Dr. Yasuda Ryoheio (Max Planck Florida Institute for Neuroscience and Scientific Director) was invited as the lecturer.。The theme is "Decoding Synaptic Signaling Dynamics Underlying Plasticity"is。Behavioral Time Scale Plasticity (BTSP) is、It has attracted attention as synaptic plasticity that occurs on time scales (in seconds) related to individual-level learning.、The molecular mechanism is unknown。Dr. Yasuda and colleagues explored this problem using improved Ca2+/calmodulin-dependent kinase II (CaMKII) sensors.、10-100 seconds after BTSP induction、Delayed CaMKII activation in the dendrites was found to occur stocastically.、It was discovered that IP3-dependent intracellular Ca2+ release is involved in this phenomenon。It was an extremely interesting story that explored the individual-level learning mechanisms.。

The 169th Brain Club was held on July 28, 2025, co-sponsored by WPI-BIo2Q. This time, we welcomed Dr. Hasegawa Tetsuo (Leader of the Immunology Unit, Institute of Medicine, Cambridge University) as our lecturer.。The presentation is "3D imaging of the synovium defines an intricate immunological defense system at the blood-joint barrier". Joint pain is a systemic inflammation、Often observed。This phenomenon is thought to be mediated by circulating IgG immune complexes.、The cause was not well understood。Dr. Hasegawa、This problem was solved by developing a new technique to observe the entire synovium of the mouse knee joint。Beautiful 3D imaging of synovium、Everyone once again felt the importance of "seeing" in the way new insights can bring to mind.。

Gordon Research Conference held at New Hampshire from June 8th to 13th (The topic was on the Excitatory Synapses and Brain Function) .。Oishi Mitsuhiro-kun, a graduate student who accompanied him, made a poster presentation.、He has achieved the great achievement of being selected as a poster award from among the many excellent poster presentations.。13After the GRC, we visited Harvard Medical School and held a seminar hosted by Dr. Pascal Kaeser.。Photo: Nozawa, who is studying abroad at Kaeser Research Institute.、Oishi-kun、Dinner with Pascal (after meals)。

The 168th Brain Club was held on April 25, 2025, co-hosted with WPI-BIo2Q. This time, Dr. Eric Hosy (IINS) will be the lecturer., CNRS-University of Bordeaux, Bordeaux, France) welcomed。The presentation is "Super-resolution microscopy to resolve the intimate organization and function of the synapse.". Dr. Hosy is one of the developers of PAINT technology.、Using this technology and super-resolution microscopes such as STORM, we observe multiple synaptic molecules at a spatial resolution of approximately 10 nm.、We talked about changes in localization of synaptic molecules before and after synaptic plasticity.

It has been announced that the International Union of Physiological Societies (IUPS))was establishedAcademy FellowHe was elected to。

IUPS was founded in 1889, and was founded by the International Conference on Physiological Sciences (Association for the Universal Physiology).、1953It is the only international academic organization representing the physiological researcher community, officially established in 2019.。Incidentally, Dr. Kato Motoichi, the first professor of physiology at Keio University School of Medicine, was first published internationally on unattenuated conduction at the IUPS Congress held in Stockholm in 1926.。