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Welcome to Yuzaki Lab
    慶應義塾大学医学部柚崎研(神経生理学)では「神経活動や環境の変化が、どのようにして記憶・学習を引き起こし、どのように神経回路網そのものを変化させるのか」というテーマに沿って研究を行っています
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意欲あふれる方の参加を待っています。これからの基礎科学を担う若手研究者を積極的に育てていきます。
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   医学部博士課程はこちら
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Older Papers

Dr. Yuzaki’s older papers


Matsuda, K., Kamiya, Y., Matsuda, S., Yuzaki, M. Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. Mol. Brain Res., 100:43-52, 2002.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12008020


Matsuda, S., Yuzaki, M. Mutation in hotfoot-4J mice results in retention of delta2 glutamate receptors in ER. Eur. J. Neurosci., 16:1507-1516, 2002.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12405964


Hirai, H., Launey, T., Mikawa, S., Yanagihara, D., Kasaura, T., Miyamoto, A., Yuzaki, M. Antibody against a putative ligand-binding site reveals delta2 glutamate receptor receptor function. In: Ann. NY. Acad. Sci. Vol.978. The Cerebellum-Recent Developments in Cerebellar Research. (Highstein, S.M., Thach, W.T. eds), pp519, New York Academy of Sciences, New York, 2002.


Tomomura, M., Rice, D.S., Morgan, J.I., Yuzaki, M. Purification of Purkinje cells by fluorescence-activated cell sorting from transgenic mice that express green fluorescent protein. Eur. J. Neurosci., 14, 57-63, 2001.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11488949


Tomomura, M., Fernandez-Gonzales, A., Yano, R., Yuzaki, M. Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS. Oncogene, 20, 1022-1032, 2001.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11314040


Kohda, K., Wang, Y., Yuzaki, M. Mutation of a glutamate receptor motif reveals its role in gating and d2 receptor channel properties. Nature Neurosci., 3:315-322, 2000.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10725919


Kurschner, C., Yuzaki, M. Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. J. Neurosci., 19, 7770-7780, 1999.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10479680


Yuzaki, M., Connor, J.A. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J. Neurophysiol., 82, 2820-2826, 1999.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10561449


Shiraiwa, N., Inohara, N., Okada, S., Yuzaki, M., Shoji, S., Ohta, S. An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J. Biol. Chem., 271, 13258-13265, 1996.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8662675


Yuzaki, M., Forrest, D., Curran, T., Connor, J.A. Selective activation of calcium permeability by aspartate in Purkinje cells. Science, 273, 1112-1114, 1996.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8688099


Yuzaki, M., Forrest, D., Verselis, L.M., Sun, S.C., Curran, T., Connor, J.A. Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture. J. Neurosci., 16, 4651-4661, 1996.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8764653


Forrest, D., Yuzaki, M., Soares, H.D., Ng, L., Luk, D.C., Sheng, M., Stewart, C.L., Morgan, J.I., Connor, J.A., Curran, T. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron, 13, 325-338, 1994.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8060614


Yuzaki, M., Furuichi, T., Mikoshiba, K., Kagawa, Y. A stimulus paradigm inducing long-term desensitization of AMPA receptors evokes a specific increase in BDNF mRNA in cerebellar slices. Learn. Mem., 1, 230-242, 1994.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10467600


Yuzaki, M., Mikoshiba, K., Kagawa, Y. Characterization of metabotropic glutamate receptors in cultured Purkinje cells. Ann. NY. Acad. Sci., 707, 505-508, 1993.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10467600


Yuzaki, M., Mikoshiba, K., Kagawa, Y. Cerebellar astrocytes specifically support the survival of Purkinje cells in culture. Biochem. Biophys. Res. Commun., 197, 123-129, 1993.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10467600


Miyazaki, S., Yuzaki, M., Nakada, K., Shirakawa, H., Nakanishi, S., Nakade, S., Mikoshiba, K. Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science, 257, 251-255, 1992.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=1321497


Yuzaki, M., Mikoshiba, K. Pharmacological and immunocytochemical characterization of metabotropic glutamate receptors in cultured Purkinje cells. J. Neurosci., 12, 4253-4263, 1992.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10467600


Miyazaki, S., Shirakawa, H., Nakada, K., Honda, Y., Yuzaki, M., Nakade, S., Mikoshiba, K. Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca2+-induced Ca2+ release and Ca2+ oscillations in hamster eggs. FEBS Lett., 309:180-184, 1992.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=1324195


Yoshikawa, S., Tanimura, T., Miyawaki, A., Nakamura, M., Yuzaki, M., Furuichi, T., Mikoshiba, K. Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster. J. Biol. Chem., 267:16613-16619, 1992.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=1322910


Kagawa, Y., Yuzaki, M., Ohta, S., Tominaga, K., Otsuka, M., Kanazawa, I. Multiple deletions of mitochondrial DNA in patients with familial mitochondrial myopathy. In: Prog in Neuropathol Vol.7. Mitochondrial Encephalomyopathies. (Sato, T., DiMauro, S. eds.), pp129-151, Raven Press, New York, 1991.


Yuzaki, M., Kudo, Y., Akita, K., Miyawaki, A., Mikoshiba, K. MK-801 blocked the functional NMDA receptors in identified cerebellar neurons. Neurosci. Lett., 119:19-22, 1990.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=2151466


Yuzaki, M., Miyawaki, A., Akita, K., Kudo, Y., Ogura, A., Ino, H., Mikoshiba, K. Mode of blockade by MK-801 of N-methyl-D-aspartate-induced increase in intracellular Ca2+ in cultured mouse hippocampal neurons. Brain Res., 517:51-56, 1990.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=2165437


Yuzaki, M., Ohkoshi, N., Kanazawa, I., Kagawa, Y., Ohta, S. Multiple deletions in mitochondrial DNA at direct repeats of non-D-loop regions in cases of familial mitochondrial myopathy. Biochem. Biophys. Res. Commun., 164:1352-1357, 1989.
http://www.ncbi.nlm.nih.gov/pubmed?term=2590206

Maeda, N., Wada, K., Yuzaki, M., Mikoshiba, K. Autoradiographic visualization of a calcium channel antagonist, [125I]w-conotoxin GVIA, binding site in the brains of normal and cerebellar mutant mice (pcd and weaver). Brain Res., 489:21-30, 1989.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=2743150


Ozawa, S., Nakamura, T., Yuzaki, M. Cation permeability change caused by L-glutamate in cultured rat hippocampal neurons. Brain Res., 443:85-94, 1988.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=2896060


Ozawa, S., Yuzaki, M. Patch-clamp studies of chloride channels activated by gamma-aminobutyric acid in cultured hippocampal neurones of the rat. Neurosci. Res., 1:275-293, 1984.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=6100323