Thesis of Nishiyama Assistant Professor is now Accept the Journal of Neuroscience。Re-evaluation of neurodegeneration in "error char mouse：Sustained ion influx is not the cell death by autophagy、Is the paper that cause cell death accompanied by autophagy "。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.jneurosci.org/cgi/content/abstract/30/6/2177

A phenomenon that neuronal cell death caused by glutamate receptors hyperexcitability、It has been known as the "excitable cell death"。Error char mouse、The point mutations δ2 type glutamate receptor、Cerebellar Purkinje cells by modifying be a mutant mice that cause cerebellar ataxia、It has been used as a model of excitable cells death for a long time。In the error char mouse、Or cells to die by hyperactivity of the "autophagy" the Purkinje cells engulf yourself、Or die by other causes was a long time unknown。In this paper、Autophagy is a phenomenon to be associated with cell death、It was revealed for the first time that it is not the cause。

12/24/2009 9:09 PM | What's New