At the 37th Japan Glaucoma Society symposium held in Shizuoka, "Latest basic research aimed at restoring nerve function," Yuzaki gave a talk on glaucoma treatment by repairing retinal synapses using CPTX.。
University of Tokyo, Professor Megumi Honjo、Tokyo Medical Research Institute Takayuki Harada is the organizer。Other speakers are Dr. Akiko Sotozono, Tokyo Jikei Medical University、Tokyo Metropolitan Institute of Medical Science, Dr. Kazuhiko Namegata、It was Professor Shinichi Fukuda from the University of Tsukuba.。

Science Council of JapanPublic Symposium/34th Brain Century Symposiumwas held on Saturday, September 26th at the Science Council of Japan auditorium.。
The theme this time is “Brain and Generative AI”、The special lecture was titled "Brain and Artificial Intelligence - Two Intelligent Systems"、It was Professor Shunichi Amari, a specially appointed professor at Teikyo University Advanced Research Institute.。Next, “Understanding the Brain”、"Protect your brain"、"Creating a brain"、There were lectures on the latest research results from the four fields of "nurturing the brain"。Yuzaki is the chairperson of the Neuroscience Subcommittee of the Science Council of Japan, Committee on Basic Medicine.、Served as the opening greeting and moderator for the panel discussion.。
On-demand distribution will also be available at a later date.。

The dopamine synapse connector research project promoted by Yuzaki et al.、JST's Deep Tech Startup International Expansion Program (D-Global)was adopted by。After the kickoff meeting、A social gathering was held to celebrate the start of the project.。

Mr. Yamazaki (Tokyo University of Science)、The research results of Mr. Kakegawa (Gakushuin University) while he was a member of the Yuzaki laboratory are、Molecular Therapy .。
In this study、Two families with hereditary cerebellar ataxia caused by mutations in the CBLN1 gene, which plays an important role in synapse formation, were discovered.。further、We created mice with the same genetic mutation as the patient.、Abnormalities in CBLN1 impair synapse formation and function.、We have clarified the mechanism that causes cerebellar ataxia.。What is especially important is、The therapeutic effect was also obtained in adult mice that had already developed cerebellar ataxia.。By introducing the normal CBLN1 gene into cerebellar glial cells using an AAV vector,、Reduced synapses recover、It was also shown that the symptoms of cerebellar ataxia were significantly improved.。
This research、In addition to uncovering a new cause of hereditary cerebellar ataxia that was previously unknown.、This study demonstrates the possibility of improving neurological symptoms by rebuilding synapses even after the onset of symptoms.。It is expected that this will lead to the development of gene therapy for hereditary cerebellar ataxia in the future.。

Yuzaki gave a special lecture on September 15th at Nara Prefectural Medical University.。There was a lively question and answer session, which significantly extended the lecture time.。The audience includes high school and university juniors.、I also had a great time with my son's colleagues from his training days.。Unfortunately it was raining, but we were able to see the new school building and research building that matched the ancient capital.。(Dr. Saito, Physiologist, who planned the project)、Thank you)。

The ``Seminar for Exchange of Opinions in the Field of Brain Research'', a Japan-US science and technology cooperation project, has been held since 2000 based on an MOU between the US and Japanese governments.、2026Held at Rihga Royal Hotel Osaka from June 15th to 16th。

This year's theme is "Convergence of RNA Processing Alterations and Synaptic and Neuronal Dysfunction in Neurodegeneration."、Starford University Aaron Gitler on the US side、The Japanese side was organized by Professor Yuka Koike from Niigata University.。for 2 days、Pathological mechanisms of neurodegenerative diseases such as ALS and AD、There was a lively discussion from the perspective of RNA processing and synaptic disorders.。Professor Okano and Yuzaki participated from Keio University.。

Yuzaki was invited to the 68th Japanese Society of Child Neurology held in Utsunomiya on June 6th.、Special lecture "Psychiatric and neurological diseases and developmental disorders approaching through synapse research" was given.。

The 174th Brain Club was held on April 10th.。Lipid Regulation of Ion Channels in Neuronal Excitability: With the theme of Molecular and Structural Mechanisms.、The following two speakers spoke.
Dr. Yasushi Okamura （Specially Appointed Researcher, WPI-PRIMe, Osaka University）
Electrophysiological Analysis of Lipid Regulation of Inhibitory Neurotransmitter Receptors and K+ Channels
Dr. Radu Aricescu (Group Leader, MRC Laboratory of Molecular Biology, UK）
Structural Basis of Lipid Regulation of GABAA Receptors

The 173rd Brain Club was held on March 31st.。send、The following 4 from the UK, France, US, and BelgiumInviting famous researchersKishita Mini-symposium on “Symposium on Synapses: From Assembly to Receptor Mechanisms"is。

• Ingo Greger (MRC Laboratory of Molecular Biology, UK) “Relating AMPA receptor structure to function at the synapse”
• Joris de Wit (VIB Center for Brain & Disease Research, Belgium) “From proteins to circuits: defining pyramidal neuron input architecture and remodeling in disease”
• Pierre Paoletti (Institute of Biology of the ENS, France) “Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites”
• Yimin Zou (University of California, San Diego, USA) “Emerging Roles of Planar Cell Polarity in Assembly, Maintenance, and Function of Glutamatergic Synapses”

Yuzaki gave an oral presentation and Assistant Professor Thomas Chater gave a poster presentation at the 5th UK-Japan Neuroscience Symposium (sponsored by MRC-AMED) held at Jesus College, Cambridge University, UK.。Mr. Thomas won the Excellence Award.、Obtained invitation to the 6th Symposium。

The 172nd Brain Club was held on Friday, November 7th.。This time, Dr. Florian Levet (Quantitative Imaging of the Cell team),The Interdisciplinary Institute for Neuroscience in Bordeaux) was invited as a lecturer.。The title of the presentation was “Making Sense of Synaptic Organization”: From Super-Resolution Imaging to Multimodal and Multidimensional Analysis」です。Dr. Florian、Using single molecule localization microscopy (SMLM)、Revealing the existence of discrete nanodomains in synapses and、Established quantitative methods for analyzing protein configuration at the nanoscale。Currently、We particularly focus on developing a computational framework specialized for nanoscale neuroimaging data analysis.、further、Deep 3D imaging with adaptive optics + single objective light sheet (soSPIM)、High-content soSPIM pipeline for large-scale analysis of organoids/neurospheres、Correlation between molecular arrangement and morphology STED–PALM、He also talked about spectral SMLM, which identifies multiple proteins simultaneously.。I once again realized that this kind of computational scientific approach is essential in order to utilize advanced microscopy techniques in biological science and neuroscience.。

The 171st Brain Club was held on October 2, 2025, co-sponsored by WPI-BIo2Q. This time, Dr. Kiyonaka Shigeki (Professor, Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University；We welcomed the lecturer to the Institute for Quantum Chemical Innovation, the Future Society Creation Organization (Director of the Institute for Quantum Chemical Innovation).。The topic is "Visualization of native receptors and development of cell-selective regulation techniques for elucidating higher brain functions."。Dr. Kiyonaka and others、Towards elucidating brain function、Integrated in neurons and glial cellsWe are developing receptor visualization and regulation technologies。In particular, we provide a precise and quantitative solution to the dynamic changes of glutamate receptors, which hold the key to the molecular mechanisms of memory and learning.We were introduced to the chemical methodology for analyzing。Also、Existing chemogenetics are cell-controlledIn contrast to the resolution、Endogenous receptorsWe also talked about technology to increase the time resolution that corresponds to activation.。I was once again impressed by the magical chemical modifications and compound synthesis based on the structure of receptors.。We hope to continue to elucidate brain functions through collaborative research using new tools.。