× 21 (July 2013 numbers)「Transport Saum and brain」A review of Kakegawa, Koda-Yuzusaki "new synaptic plasticity mechanism by'm not -δ2 type glutamate receptors and Cbln1 that just to form a synapse" was published in the。

2013It was held at the Niigata University Brain Science Institute on July 26, years43rd Niigata neurology Summer SeminarAt yuzu Saki gave a lecture。

Between July 23 to 25, 2013 in Shiga Prefecture Laforet Biwako、I took part in the new academic area "nerve sugar chain biology" group meeting。Yuzusaki from our laboratory、Matsuda、Otsuka、Suzuki will participate、I made a hot debate。

2013July 18 - The was carried out in the United States Seattle US-Japan Brain Research Collaborative Program was held in 20 days。今回のテーマは“Current Trends and Future Directions of Synaptic Plasticity Research”です。Mr. Suzuki of Assistant Professor in addition to the invited talk of Yuzusaki from our department、Graduate students of Otsuka Mr. gave a poster presentation。

Iijima TakashiToshi Dr. our laboratory born (Assistant Professor → Switzerland while studying) is、2013Of the yearJapanese Neural Chemical Society Award for YoungIt was won。congratulations! Double award in conjunction with Ishida's Neuroscience Society。

2013Gordon meeting held in Switzerland · Les Diablerets from June 9 year up to 14 days Yuzusaki at (excitatory synapses and brain function) gave the invited talk。Control mechanism and structure at the front and rear of excitatory synapses、And hot discussion from a variety of approaches for functional and morphological plasticity and pathology associated with memory and learning have been made。

幸田講師（専任）が准教授に昇進しました　 😀 　また、鈴木邦道くん(TA (Extraordinary))、Timotheus Budisantosoくんが研究室に参加しました。

This laboratory acquired Aya Ishida Dr. degree in (currently the United States during the study) is、2013Of the yearby the Japan Neuroscience SocietyIt was won。Congratulations!

Yuzu Saki than the Ministry of Education, Culture, Sports, Science and Technology、Was awarded the Education, Culture, Sports, Science Minister's Commendation of the 2013 fiscal year the field of science and technology。Photo Kaoru Inokuchi teacher of Toyama, which became a winner at the same time、National Institute for Physiological Sciences of Tadashi Isa teacher groups (Kyoto University, Watanabe large teacher、Fukushima Prefectural Medical University Kazuto Kobayashi teacher)、It is a commemorative photo of the Osaka University, 栁澤 teacher of young science Award。MoreClick here. 。

Exchange of information between nerve cells takes place in the synapse。Long-term suppression of transmission efficiency of synaptic (LTD) is、Is the foundation process of learning and memory in the brain。In the cerebellum、Cerebellar granule cells by learning - LTD in synaptic transmission between Purkinje cells)It plays an essential role in memory to be involved in the movement that occurs (such as dexterity and timing)。LTD In general postsynaptic neurons、Caused by a reduction in the number of AMPA receptor to receive the glutamic acid。Features of cerebellar LTD is、It is to require delta type 2 glutamate receptor specifically present in Purkinje cells in addition to。The cause and mechanism had been left for many years remains a mystery。Finally succeeded in solving this mystery in this paper。Delta 2 receptors by controlling the phosphorylation state of the AMPA receptor、It was found that acts as a so-called master key to determine whether or not occur or LTD occurs。

In this study, Drs. Kohda and Kakegawa showed that the serine phosphorylation of AMPA receptors required prior dephosphorylation of the nearby tyrosine residue. By interaction with a tyrosine phosphatase, δ2 glutamate receptors regulated tyrosine dephosphorylation status of GluA2 to gate inducibility of LTD. These findings will provide better understanding of general mechanisms regulating AMPA receptor endocytosis during synaptic plasticity. This paper has been published in PNAS.。For Press releaseClick here. 。

2012Dr. Ishida's paper, whichappeared in Neuron has beenThere has been introduced in the Preview as paper should be noted in Developmental Cell magazine。

Read the Preview at: Choreographing the axo-dendritic dance. Dev Cell 23:923-924,2012.

Keiko Matsuda's paper, which was published in the European Journal of Neuroscience (EJN) in 2011 hasbeen selected asthe EJN most cited papers in 2011-12He was elected to。

The original articles is here→Matsuda K, Yuzaki M. Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci 33:1447-1461,2011