The 160th Brain Club welcomed Dr. Teruyoshi Nakagawa (Vanderbilt University), who was temporarily returning to Japan.。The title is "Visualizing putative ions and water molecules in the ion conduction path of the AMPA receptor"。AMPA receptors are responsible for rapid excitatory transmission in the central nervous system、Elucidation of its structure and function is an important theme that expands the possibility of clinical application as well as basic science.。Dr. Nakagawa uses cryo-EM to、2.3Ca by resolution reaching Ų⁺The structure of transmissive AMPA receptor has been clarified。Interestingly, when a highly conserved gate (SYTANLAAF) in the AMPA receptor opens upon channel opening,、Ca in the same area²⁺you have told me to join。Probably Na⁺Along with inhibiting the influx of other ions such as、efficient Ca²⁺It is considered a mechanism for achieving transparency.、We all listened with great interest.。

Nat Commun. 2023 May 30;14(1):3113. doi: 10.1038/s41467-023-38854-2.

Afferent convergence to a shared population of interneuron AMPA receptors

Reagan L Pennock, Luke T Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I Wadiche

PMID: 37253743

The 159th Brain Club was held on August 10th with Dr. Mototaka Suzuki from the University of Amsterdam。Subject: General anesthesia decouples cortical pyramidal neurons: it's an update。Face-to-face only、And I was worried that there would be few people because it was during the summer vacation.、Many people participated and had lively discussions.。(I missed the timing to take a picture, so only some people are in the picture)。

Fund for the Promotion of International Joint Research (International Leading Research) "Multidimensional Analysis of Memory Mechanisms - From nm to mesoscale/millisecond to day scale"'s first Retreat in GotembaIt was held from August 5th to 8th at。Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience (IINS) -BordeauxNeurocampus(France) and domestic (Kyoto University, Keio University, Tokyo University, Niigata University, NIG) gathered many PIs, postdocs and researchers.、Discussions continued late into the night。Ms. Delina, who gave an oral and poster presentation from Yuzuzaki Lab, was selected as one of the three poster award winners.。Thank you for your visit。With the support of this grant, for the next 7 years (10 years if it passes the examination)、International exchange and joint research centered on graduate students, postdocs, and young researchers are expected to progress.。

Mr. Nozawa, who received his degree (Doctor of Medicine) in March this year,、2023Received the Toshihiko Tokizane Memorial Award for Outstanding Doctoral Research in Neuroscience at the Japan Neuroscience Conference in Sendai。Nozawa also attended the degree conferment ceremony held at Keio University in March.、Selected as a representative of the Graduate School of Medicine。Congratulations!。