Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2025/5/12 Journal Club (Suyama)

Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

Míriam Toledo, Sara Martínez-Martínez, Matthias of their…Patrice of dogs , Rubén Nogueiras, Marc Claret
Night Metab. 2025 Apr 22.
doi: 10.1038/s42255-025-01280-3.

posted on 05/10/2025 8:26 PM

2025/4/28 Journal club (Thomas)

Thomas presented the following paper

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Wright et al., Science, 2025

https://www.science.org/doi/10.1126/science.ads4706#supplementary-materials

posted on 04/28/2025 1:44 PM

2025/04/21 Journal Club (Dilina)

TNF-NF-kB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

Tae Wan Kim, So Yeon Koo, Markus Riessland, …, Ralph Garippa, Doron Betel, Lorenz Studer.

Cell. 187,3671–3689, Published. July11,2024.

PMID: 38866017. DOI: 10.1016/j.cell.2024.05.030

posted on 04/18/2025 8:16 PM

2025.02.17 Journal club (Ishikawa)

Visual experience reduces the spatial redundancy between cortical feedback inputs and primary visual cortex neurons
Neuron. (2024)112(19):3329-3342.. doi: 10.1016/j.neuron.2024.07.009. Epub 2024 Aug 12.

Rodrigo F Dias , Radhika Rajan , Margarida Baeta , Beatriz Belbut , Tiago Marques , Leopoldo Petreanu

posted on 02/16/2025 1:12 PM

2025.2.10 Journal club (Thomas)

“Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites.” Cell flight. 188,2 (2025): 484-500.e22. doi:10.1016/j.cell.2024.11.029 Benedetti, Lorena et al.

posted on 02/10/2025 11:44 AM

2025.1.27 Journal club (Arai)

Nat Commun. 2024 Dec 12;15(1):10340. doi: 10.1038/s41467-024-53901-2.
Membrane potential states gate synaptic consolidation in human neocortical tissue
Mittermaier and Geiger et al.

posted on 01/27/2025 8:34 AM

2025/1/20 Journal Club (Shiozaki)

Defects in hair cells disrupt the development of auditory peripheral circuitry

Bottom, R.T., Coin, Y., Siebald, C. et al. Defects in hair cells disrupt the development of auditory peripheral circuitry. Nat Commun 15, 10899 (2024). https://doi.org/10.1038/s41467-024-55275-x

posted on 01/18/2025 9:14 PM

2025January 6, 2019 Journal Club (Matsuda)

https://www.nature.com/articles/s41593-024-01813-1#Sec1

posted on 01/04/2025 5:25 PM

2024/12/16 Journal Club (Haowei Li)

Hypothalamic deep brain stimulation augments walking after spinal cord injury.

For, N., Squair, J.W., Aurelius, V. et al.
Night With 30, 3676–3686 (2024).
https://doi.org/10.1038/s41591-024-03306-x

posted on 12/14/2024 8:14 PM

2024/12/2 Journal Club (Takasugi)

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.

Nees, T.A., Wang, N., Adamek, P. et al. Nat Commun 14, 1899 (2023). https://doi.org/10.1038/s41467-023-37602-w

posted on 12/02/2024 3:38 PM

2024/1125 Journal Glub(A.Ishikawa)

NMDA receptors regulate the firing rate set point
of hippocampal circuits without altering
single-cell dynamics

Neuron.
. 2024 Nov 5:S0896-6273(24)00735-9. doi: 10.1016/j.neuron.2024.10.014. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

 

posted on 11/24/2024 8:06 PM

2024/11/18 Journal Club (M. Itoh)

Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization.

Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH.

Nat Struct Mol Biol. 2024 Oct;31(10):1601-1613. doi: 10.1038/s41594-024-01369-5. Epub 2024 Aug 13.

PMID: 39138332

https://pubmed.ncbi.nlm.nih.gov/39138332/

https://www.nature.com/articles/s41594-024-01369-5

posted on 11/15/2024 5:03 PM