Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2025/12/1 Journal Club (Oishi)

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth

Corina Anastasak, Rui Mu, Chloe M. in Kerna, Xuanwei Li, Rasha Barakat, Joshua P. Cholesterol, Yunqing Gao, Olivia M. Cobb, Xinguo Lu, Charles G. Eberhart, Joanna J. Phillips, Jennifer M. Rays, Sonika Dahiya, Steven J. Mennerick, Fausto J. Rodriguez, David H. Gutmann

https://www.cell.com/neuron/fulltext/S0896-6273(25)00591-4

posted on 11/17/2025 8:36 PM

2025Journal Club (Matsuda) on November 10th

https://www-sciencedirect-com.kras.lib.keio.ac.jp/science/article/pii/S0896627325007482?via=ihub

posted on 11/08/2025 4:56 PM

2025/10/06 Journal Club (Ishikawa)

Arousal as a universal embedding for spatiotemporal brain dynamics
Ryan V. Raut, Zachary P. Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E. Racele, Adam Q. Bauer, Steven L. Brunton, Bingni in. Brunton & J. Nathan Kutz

Nature, Published: 24 September 2025

posted on 10/04/2025 1:22 AM

2025/09/29 Journal Club (Li)

Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays

So, Longyou Xiao, Junwu Ma, Kaixi Shi, 李六后六后, Feng Feng, Pengfei Xie, Yu Dai, Qiuju Yuan, Wutian Wu, Limin Rong, and Liumin He

Science Advances, 3 Jul 2024, Flight 10, Issue 27
DOI: 10.1126/sciadv.ado9120

posted on 09/28/2025 5:57 PM

2025.9.22. Journal club (Takeo)

Lace et al.

Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA

Science 2025 Aug 7;389(6760) doi: 10.1126/science.ads3204. Epub 2025 Aug 7

PMID: 40773560

posted on 09/19/2025 4:10 PM

2025/9/8 Journal Club (Suyama)

Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling.

Feetham et al., 2024 Nat. Comm

posted on 09/07/2025 11:59 PM

2025/08/04 Journal Club (Dilina)

Nanobody therapy rescues behavioral deficits of NMDA receptor hypofunction

Mathieu Oosterlaken, Angelina Rogliardo, Tatiana Lipina, Pierre-André Lafon1,……Julie Kniazeff, Philippe Rondard

Published online: Nature. 23 July 2025

https://www.nature.com/articles/s41586-025-09265-8

posted on 08/01/2025 8:03 PM

2025/7/28 Journal Club (Thomas)

Thomas presented this paper –

Nutrients activate distinct patterns of small-intestinal enteric neurons, Nature, 2025

https://www.nature.com/articles/s41586-025-09228-z

 

posted on 07/27/2025 8:23 PM

2025/07/07 Journal Club (Oishi)

A parallel tonotopically arranged thalamocortical circuit for sound processing

Zhikai Zhao, Xiaojing Tang, Yiheng Chen, Jie Tao, Mahiber Platt, Zhiqi Yang, Linhan Yang, Meng Wang, Shanshan Liang, Kuan Zhang, Yun Zhang, Chunqing Zhang, Lina Wang, Yanjiang Wang, Arthur Konnerth, Hongbo Jia, ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder,
Xiang Liao, Sunny C. Li, Xiaowei Chen.

Neuron., doi: : 10.1016/j.neuron.2025.03.022 (2025).

posted on 07/06/2025 12:24 PM

2025/06/16 Journal Club (Ishikawa)

Nonlinear recurrent inhibition through facilitating serotonin release in the raphe
Michael B. Lynn, Sean D. Geddes, Mohamad Chahrrour, Sébastien Maillé, Léa Caya-Bissonnette, Emerson Harkin, They ripen Harvey-girard, Samir haj-dahmane, Richard Naud & Jean-Claude Béique
Nature Neuroscience volume 28, pages1024–1037 (2025)

posted on 06/15/2025 3:12 PM

2025/05/26 Journal Club (Li)

Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons

Tatsuya Osaki, Tomoya Duenki, Siu yu a. Chow, Yasuhiro Ikegami, Romain Beaubois, Timothy Levi, Nao made-laugh, Yoji Hirano & Yoshiho Ikeuchi
Nat Commun 15, 2945 (2024).
https://doi.org/10.1038/s41467-024-46787-7

posted on 05/26/2025 9:14 AM

2025.5.19. Journal club (Takeo)

 

Science 1 May 2025 Flight 388, Issue 6746 pp. 538-54

Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit

Cheng Lyu, Zhuoran Li, Chuanyun Xu, Kenneth Kin Lam Wong, David J. Luginbuhl, Colleen N. McLaughlin, Qijing Xie, Tongchao Li, Hongjie Li, and Liqun Luo

PMID: 40310920 DOI: 10.1126/science.ads7633

posted on 05/16/2025 8:33 PM