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Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2019/7/8 Journal Club (Miura)

In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation

Margaret T. Davis, Ansel Hillmer, Sophie E. Holmes, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Richard E. Carson, John H. Krystal, and Irina Esterlis

This paper has been published in PNAS June 4, 2019 116 (23) 11490-11495

posted on 07/05/2019 9:39 PM

2019/7/1 Journal Club (Nozawa)

Hafner, A.-S., Donlin-Asp, P. G., Leitch, B., Herzog, E., & Schuman, E. M. (2019).

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments.

Science, 364(6441), eaau3644. https://doi.org/10.1126/science.aau3644

posted on 06/28/2019 5:29 PM

2019/6/17 Journal Club (Aimi,zh-CN)

Science. 2019 Apr 12;364(6436)

Ultrapotent chemogenetics for research and potential clinical applications.

Magnus CJ, Lee PH, Bonaventura J, Zemla R, Gomez JL, Ramirez MH, Hu X, Galvan, Basu J, Michaelides M, Sternson SM.

PMID: 30872534

posted on 06/14/2019 6:58 PM

2019.6.10 Journal Club (Suyama)

Neuron.. 2019;102:653–6.
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits
Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, et al. Neuron.. Cell Press; 2019.

Journal club by Shigetomo Suyama

posted on 06/10/2019 11:38 AM

2019.5.13 Journal Club (Bannai)

Cell Rep. 2019 Apr 16;27(3):658-665.e4. doi: 10.1016/j.celrep.2019.03.041.
Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer’s-Related Plasticity Impairment.
Cook SG, Goodell DJ, Restrepo S, Arnold DB, Bayer KU.

Journal club by Hiroko Bannai

posted on 04/22/2019 3:35 PM

2019/04/07 Journal Club (Yuzaki)

Orlandi C, Omori Y, Wang Y, high Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep. 2018 Oct 2;25(1):130-145.

Condomitti G, Wierda KD, Schroeder A, Rubio, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, their JN, de Wit J. An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron.. 2018 Oct 10;100(1):201-215.

posted on 04/07/2019 3:00 PM

2019/3/18 Journal Club (Kono)

Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

posted on 03/16/2019 8:33 PM

2019/03/11 Journal Club (Kakegawa)

Fossati et al., EMBO Journal (2019) e99529

Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and beta1-integrin.

posted on 03/01/2019 9:13 PM

2019/02/04 Journal Club (Motohashi)

Front. Behav. Neurosci., 14 June 2010 | https://doi.org/10.3389/fnbeh.2010.00029
Naoki Matsuo, Keizo Takao, Kazuo Nakanishi, Nobuyuki Yamasaki, Koichi Tanda and Tsuyoshi Miyakawa

posted on 02/04/2019 10:20 AM

2019/1/21 Journal club by Arai

Nature. 2018 Dec;564(7735):213-218
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Leroy F, Park J, The barbershops, Brann DH, Meira T, Boyle LM, buss EW, Kandel ER, Siegelbaum SA.

PMID: 30518859

posted on 01/20/2019 7:25 AM

2019/01/07 Journal Club (Yamasaki,,en,e3,,bg,j.neuron.2018.03.034,,en,Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors,,en,Regan MC,,en,Grant T,,en,McDaniel MJ,,en,Karakas E,,el,Zhang J,,zh-CN,Traynelis SF,,en,Grigorieff N,,af,Furukawa H,,en)

http://science.sciencemag.org/content/early/2018/12/12/science.aav1483.long#sec-11

 

posted on 01/04/2019 11:35 AM

2018/11/19 Journal Club (Ishida,,en,Ian Schmitt et al.,,en,Thalamic amplification of cortical connectivity sustains attentional control,,en,www.nature.com/nature/journal/v545/n7653/pdf/nature22073.pdf,,en)

https://www.nature.com/articles/s41586-018-0633-x

posted on 11/16/2018 3:10 PM