Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2021/6/21 Journal Club(Shiozaki)

Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder

Naosuke Hoshina, Erin M. Johnson-Venkatesh, Miyuki Hoshina, Hisashi Umemori

DOI: 10.1126/science.aaz3893

posted on 06/21/2021 9:24 AM

2021/06/14 Journal Club (Ohgaki)

Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice

Matthew B. Veldman, Chang Sin Park, Charles M. Eyermann, Jason y. Zhang, Elizabeth Zuniga-Sanchez, Arlene A. Hirano, Tanya L. Daigle, Nicholas N. Foster, Muye Zhu, Peter Langfelder, Ivan A. Lopez, Nicholas C. Gap, S. Lawrence Zipursky, Hongkui Zeng, Hong-Wei Dong, X. William Yang

Neuron., Volume 108, Issue 1, 14 October 2020, Pages 111-127. e6
DOI:https://doi.org/10.1016/j.neuron.2020.07.019

posted on 06/14/2021 11:18 AM

2021/05/31 Journal Club (Dilina)

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2-autoreceptor activity.

Matthew D. Lycas, Ash L. Ejdrup, Andreas T. Sørensen, Nicolai O. Haahr, Søren H. Jørgensen, Daryl A. Guthrie, Jonatan F. Noises, Christian Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gether

bioRxiv, Posted March 10, 2021.
https://doi.org/10.1101/2021.03.09.434538

posted on 05/28/2021 11:06 AM

2021/05/17 Journal Club (Nozawa)

Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons

Diogo Bessa-Neto, Alexander Kuhlemann, Drink Beliu, Valeria Pecoraro, Sören Doose, Natacha Retailleau, Nicolas Chevrier, David Perrais, Markus Sauer, and Daniel Choquet
bioRxiv, Posted February 28, 2021.

posted on 05/14/2021 8:25 PM

2021/05/10 Journal Club (Suyama)

The Journal of Clinical Investigation. 2021 Apr 13

Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward auto-activation loop in mice

Luis Varela, Bernardo Stutz, Jae Eun Song, Jae Geun Kim, Zhong-Wu Liu, Xiao-Bing Gao, and Tamas L. Horvath

DOI: 10.1172/JCI144239

posted on 05/10/2021 1:45 AM

2021/04/19 Journal Club (Aimi,zh-CN)

bioRxiv. Posted March 25, 2021

Neural circuitry for maternal oxytocin release induced by infant cries

Silvana Valtcheva, Habon A. Issa, Kathleen A. Martin, Kanghoon Jung, Hyung-Bae Kwon and Robert C. Froemke

doi: https://doi.org/10.1101/2021.03.25.436883

This article is a preprint and has not been certified by peer review.

posted on 04/16/2021 10:09 PM

2021-01-25 Journal Club (Ayako Ishikawa)

posted on 04/09/2021 12:59 PM

2021/03/29 Journal Club (Kakegawa)

Lee et al., Nature (Article). 2021 Feb;590(7847):612-617. doi: 10.1038/s41586-020-03060-3.

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis.

posted on 03/27/2021 12:09 AM

Journal Club 03/15/2021 (M. Yuzaki)

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Casarotto,…Eero Castrén

Cell 184:1299-1313, 2021 

posted on 03/15/2021 12:21 AM

Journal Club 2021/03/08 (M. Itoh)

The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65.

Jiang CH, Wei M, Zhang C, Shi YS.

Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2019194118. doi: 10.1073/pnas.2019194118.

PMID: 33627404

https://pubmed.ncbi.nlm.nih.gov/33627404/

posted on 03/05/2021 6:29 PM

2021.2.15 Journal club (Arai)

. 2021 Jan 6;109(1):123-134.e4.

doi: 10.1016/j.neuron.2020.09.037. Epub 2020 Oct 22.

Relocation of an Extrasynaptic GABA A Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory

Christopher M Davenport 1, Rajit Rajappa 1, Lyudmila Katchan 1, Charlotte R Taylor 1, Ming-Chi Tsai 1, Caleb M Smith 1, Johannes W de Jong 1, Don B Arnold 2, Stephan Lammel 1, Richard H Kramer 3

posted on 02/15/2021 8:29 AM

2021-01-25 Journal Club (Tokiwa Yamasaki)

Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation

Affiliations

  • 1Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • 2Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. mzhang@ust.hk.
  • 3Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. mzhang@ust.hk.

posted on 01/22/2021 9:51 PM