Suzuki assistant、Lecturer Keiko Matsuda、And Yuzusaki is、On May 27, respectivelySymposium was held at the University of Bordeaux Neurocampus "Molecular Mechanisms of Glutamate Receptor SignalingIt gave the invited talks at "。

University of Lyon Yuzusaki seminar at (Université Claude Bernard Lyon 1)The we。Jean-Louis Bessereau professor was the host。

Yuzusaki were carried out at in France of Roscoff on May 20-24 daysJacques Monod ConferenceIt gave a (ligand-gated ion channels from atomic structure to synaptic transmission) in the invited talk。Suzuki from lab Assistant Professor、Keiko Matsuda lecturer also participated had s Mai performs each poster presentation。

Ibata's paper、In Neuron magazine May 6, online version (US Eastern time 11:00).。Protein Cbln1 which has a function to create a new synapses、That is secreted from the lysosomes of nerve cells in response to neuronal activity、This study, which was revealed by the experiments using a mouse。
Lysosomes is、A cell organelles with enzymes that break down proteins、It plays a decomposition of no longer needed intracellular protein。Cbln1 was found to be present in the lysosome in the axons of nerve cells by this time of the study。Also, when the neural activity is enhanced、The contents of the lysosomes from axons that (a proteolytic enzyme and Cbln1) are both secreted out of the cells was found for the first time。From these experimental results、Destruction and synapse formation by Cbln1 extracellular environment by proteolytic enzymes、By working in concert、Possibility that the restructuring takes place in the synapse in response to neural activity is suggested。Synaptic reorganization is an entity of memory and learning、The failure have been reported in a number of mental illnesses and neurodevelopmental disorder、The results of this research are expected to lead to the development of understanding and new treatments for the normal development mechanism and these conditions。
Press releaseHere

Suzuki KuniMichisuke Christian papers of (Adjunct)Frontiers in Neurosci誌.。As part of its international activities support business Young Glia of the new academic area (glial assembly) is the result of joint research with Alexander Ditytatev Institute of Germany DZNE。Suzuki-kun is co-first author。Congratulations!。

135th Brain Club was held titled "dementia and the prion-like propagation" to welcome the Naruhito Hasegawa teacher (Tokyo Medical Research Institute, dementia, higher brain function research field)。

Orlandi C, Omori Y, Wang Y, high Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep. 2018 Oct 2;25(1):130-145.

Condomitti G, Wierda KD, Schroeder A, Rubio, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, their JN, de Wit J. An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron.. 2018 Oct 10;100(1):201-215.

Brain Bee (Brain Science Olympics)Japan representative candidate 4 people came to visit the laboratory。1After the time of the lecture、I was eager to learn to slow down the training, such as an electrical recording by the patch-clamp technique in the prism adaptation and brain sections。

Brain Bee is in the event that the NPO "the century of the brain" is performed in order to foster the next generation to learn the brain science、Japan Neuroscience Society and JapanBrain Science Society of AssociationThere has sponsored。northeast·Shikoku medium andKyushu, Kanto, the four people who won the district of qualifying Kansai Japan representative candidates will head to the world tournament after this。Also7Japan Neuroscience Society of the monthAlso done award ceremony at。

134th Brain Club is Matthew P. Mr. Anderson (Harvard Medical School)Welcomed Shi、It was held titled "Mapping the Circuits that Control Aggression via Autism Gene Convergence"。

133rd Brain Club is Shi welcomed Haruhiko Shiomi teacher (Keio University School of Medicine molecular biology classroom)、It was held titled "De novo DNA methylation and chromatin architecture during mouse gonocyte" (methylation and chromatin structure of DNA in the mouse Gore Roh site)。

Kono-san's doctoral paper、which was published in the Journal of Physiology, was featured in Perspective.。According to the comment, ”These results by Kono et al. (2019) represent a major step forward to cut the Gordian knot regarding the precise subcellular localization of NMDARs in the cerebellar microcircuitry and the cellular mechanism of PF–CF signal integration”.、They also describe that this paper represents a major step to fully understand where and how NMDA receptors function in the cerebellar circuit。The expression "cut the Gordian knot"、means "put an end to a long-standing question in an unexpected way."。Since it was tied by Gordius King、nobody was able to untie it (the Gordian knot)、when the Alexander the Great cut the knot by the sword。

Kaichi as part of the "quest activities" of high school、1Grade of Omino Mr.、3 people's Seino has been come to yuzu Saki Research。After a brief lecture、It gave a enthusiastic question and answer session with the laboratory tour。I hope you went interested in neuroscience even a little to the people of the next generation。