Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons

Tatsuya Osaki, Tomoya Duenki, Siu yu a. Chow, Yasuhiro Ikegami, Romain Beaubois, Timothy Levi, Nao made-laugh, Yoji Hirano & Yoshiho Ikeuchi
Nat Commun 15, 2945 (2024).
https://doi.org/10.1038/s41467-024-46787-7

Science 1 May 2025 Flight 388, Issue 6746 pp. 538-54

Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit

Cheng Lyu, Zhuoran Li, Chuanyun Xu, Kenneth Kin Lam Wong, David J. Luginbuhl, Colleen N. McLaughlin, Qijing Xie, Tongchao Li, Hongjie Li, and Liqun Luo

PMID: 40310920 DOI: 10.1126/science.ads7633

Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

Míriam Toledo, Sara Martínez-Martínez, Matthias of their…Patrice of dogs , Rubén Nogueiras, Marc Claret
Night Metab. 2025 Apr 22.
doi: 10.1038/s42255-025-01280-3.

Thomas presented the following paper

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Wright et al., Science, 2025

https://www.science.org/doi/10.1126/science.ads4706#supplementary-materials

The 168th Brain Club was held on April 25, 2025, co-hosted with WPI-BIo2Q. This time, Dr. Eric Hosy (IINS) will be the lecturer., CNRS-University of Bordeaux, Bordeaux, France) welcomed。The presentation is "Super-resolution microscopy to resolve the intimate organization and function of the synapse.". Dr. Hosy is one of the developers of PAINT technology.、Using this technology and super-resolution microscopes such as STORM, we observe multiple synaptic molecules at a spatial resolution of approximately 10 nm.、We talked about changes in localization of synaptic molecules before and after synaptic plasticity.

It has been announced that the International Union of Physiological Societies (IUPS))was establishedAcademy FellowHe was elected to。

IUPS was founded in 1889, and was founded by the International Conference on Physiological Sciences (Association for the Universal Physiology).、1953It is the only international academic organization representing the physiological researcher community, officially established in 2019.。Incidentally, Dr. Kato Motoichi, the first professor of physiology at Keio University School of Medicine, was first published internationally on unattenuated conduction at the IUPS Congress held in Stockholm in 1926.。

Associate Professor Kakegawa will be promoted to the Department of Life Sciences, Faculty of Science, Gakushuin University from April.。

We have been participating in Yuzuzaki Lab since April 2003, so we have been researching together for 22 years.。I wish you more and more success。

3On the 12th of the month, Yuzuzaki gave a final lecture, "Bridge Over Troubled Synapse: C1q protein、wheels、And then beyond"I did it。movieHere。

We then held a celebration of the resignation ceremony at the Meiji Memorial Museum.。Researchers who once again conducted research together in the lab、Maya Kono、technician、Secretaries、Furthermore, to all those involved in the Faculty of Medicine and Keio University.、We would like to express our sincere gratitude。photographHere。

4From Monday onwards, I will be transferred to Keio University WPI-Bio2Q.、I had the opportunity to continue my research。in recent years、.、schizophrenia、Many mental and neurological disorders such as autism spectrum disorders and developmental disorders、It is becoming increasingly thought to be a "synaptic disease" caused by synaptic abnormalities。Until now, I、We investigate how central nervous system synapses are formed and maintained.、Based on this knowledge, we have aimed to clarify the pathology of synaptic disease and develop treatment methods.。In WPI-Bio2Q、In addition to the central nervous system、Enteroinal nervous system、Autonomic nervous system、Peripheral nervous system、Furthermore, we will continue our research focusing on the synapse formation mechanism that connects these nervous systems with each organ.。With this approach、Understand the mechanism by which multiple organs connect to each other and maintain homeostasis、We hope to help you understand the pathology of diseases and develop new treatments。

Yuzuzaki is2024Uehara Prize in 2019Awarded、The award ceremony was held on March 11th.。It was a great opportunity to receive this award with Dr. Kamitori Hideki from Nagoya Institute of Technology, who has been doing joint research on Optogenetics Tools.。”

The award-winning lecture will be available on YouTubeIt is listed in。Suddenly, the screen was pitch black and I was panicked.。

3It was held on the 7th of the monthThe 3rd Keio University WPI-Bio2Q International SymposiumAt the poster presentation held at、Graduate student Shiozaki won the Poster Award (first prize).。

Visual experience reduces the spatial redundancy between cortical feedback inputs and primary visual cortex neurons
Neuron. (2024)112(19):3329-3342.. doi: 10.1016/j.neuron.2024.07.009. Epub 2024 Aug 12.

Rodrigo F Dias , Radhika Rajan , Margarida Baeta , Beatriz Belbut , Tiago Marques , Leopoldo Petreanu