The 169th Brain Club was held on July 28, 2025, co-sponsored by WPI-BIo2Q. This time, we welcomed Dr. Hasegawa Tetsuo (Leader of the Immunology Unit, Institute of Medicine, Cambridge University) as our lecturer.。The presentation is "3D imaging of the synovium defines an intricate immunological defense system at the blood-joint barrier". Joint pain is a systemic inflammation、Often observed。This phenomenon is thought to be mediated by circulating IgG immune complexes.、The cause was not well understood。Dr. Hasegawa、This problem was solved by developing a new technique to observe the entire synovium of the mouse knee joint。Beautiful 3D imaging of synovium、Everyone once again felt the importance of "seeing" in the way new insights can bring to mind.。

Thomas presented this paper –

Nutrients activate distinct patterns of small-intestinal enteric neurons, Nature, 2025

https://www.nature.com/articles/s41586-025-09228-z

A parallel tonotopically arranged thalamocortical circuit for sound processing

Zhikai Zhao, Xiaojing Tang, Yiheng Chen, Jie Tao, Mahiber Platt, Zhiqi Yang, Linhan Yang, Meng Wang, Shanshan Liang, Kuan Zhang, Yun Zhang, Chunqing Zhang, Lina Wang, Yanjiang Wang, Arthur Konnerth, Hongbo Jia, ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder,
Xiang Liao, Sunny C. Li, Xiaowei Chen.

Neuron., doi: : 10.1016/j.neuron.2025.03.022 (2025).