Translation

Welcome to Yuzaki Lab

・Yuzaki Laboratory has been relocated to the Center for Human biology - Microbiota - Quantum Computational Research (Keio University)WPI-Bio2Q.。

In addition to the central nervous system、focusing on synaptic formation mechanisms in the peripheral, autonomic and enteric nervous system、we aim to clarify the linkage between the nervous system and multiple organs, and the pathology caused by its failure, and to develop new treatments.。

Past News

Journal Club

2017/5/1 Journal Club (Suzuki)

Mark J. Wagner, Tony Hyun Kim, Joan Savall, Mark J. Schnitzer & Liqun Luo

Nature. 2017 Apr 6;544(7648):96-100. doi: 10.1038/nature21726. Epub 2017 Mar 20.

Cerebellar granule cells encode the expectation of reward.

(I will mainly talk about this.)

 

Andrea Giovannucci, Aleksandra Badura, Ben Deverett, Farzaneh Najafi, Talmo D Pereira, Zhenyu Gao, Ilker Ozden, Alexander D Kloth, Eftychios Pnevmatikakis, Liam Paninski, Chris I De Zeeuw, Javier F Medina & Samuel S-H Wang

Nat Neurosci. 2017 May;20(5):727-734. doi: 10.1038/nn.4531. Epub 2017 Mar 20.

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

 

 

posted on 05/01/2017 1:55 AM

2017. 4. 17 Journal club by Arai,,en,Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation,,en,Petrovic MM,,en,Viana da Silva S,,gl,Clement JP,,en,Vyklicky L,,en,I C,,et,González-González IM,,en,Henley JM,,en

Nat Neurosci. 2017 Apr;20(4):529-539.

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation.

Petrovic MM, Viana da Silva S, Clement JP, Vyklicky L, Mulle C, González-González IM, Henley JM.

PMID: 28192396

posted on 04/08/2017 2:11 PM

2017/3/13 Journal Club (Otsuka)

Optogenetic Control of Synaptic Composition and Function

Brooke L. muse, Aaron B. Bowen, Jeffrey S. Strong, Brian G. Hiester, Kevin C. Crosby, Emily S. Gibson, Mark L. Dell'Acqua, and Matthew J. Kennedy
Neuron., 93(3):646-660.

posted on 03/12/2017 6:50 PM

2017/2/20 Journal Club (Yuzaki)

Jin Li, Tamara Casteels, Thomas Frogner, …, Patrick Collombat, Jacob Hecksher-Sørensen, Stefan Kubicek
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Cell 168, 86–100, 2017

posted on 02/20/2017 2:18 AM

journal20170123(ibata)

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses

Xin-Sheng Wu,Sung Hoon Lee,Jiansong Sheng,Zhen Zhang5,,Wei-Dong Zhao,Dongsheng Wang,Yinghui Jin,Patrick Charnay,James M. Ervasti,Ling-Gang Wu
Neuron Volume 92, Issue 5, p1020–1035, 7 December 2016

posted on 01/22/2017 5:48 PM

1/16/2017 journal Club (Motohashi)

Jeffrey D Martell, Masahito Yamagata, Thomas J Deerinck, Sébastien Phan, By Carolyn G, Mark H Ellisman, Joshua R Sanes & Alice Y Ting

A split horseradish peroxidase for the detection of intercellular protein–protein interactions and sensitive visualization of synapses

Nature Biotechnology34,774–780(2016)doi:10.1038/nbt.3563

posted on 01/12/2017 10:51 AM

2016/12/12 Journal Club (Nozawa)

Bo Zhang and Thomas C. Südhof

J Neurosci. 2016 Aug 31;36(35):9070-83. doi: 10.1523/JNEUROSCI.1356-16.2016.

Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.

 

cf. Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses

posted on 12/10/2016 4:48 PM

2016/12/05 Journal Club (Aimi,zh-CN)

Neuron.. 2016 Nov 4. <HTML><HEAD><meta http-equiv="content-type" content="text/html;charset=utf-8"> <TITLE>302 Moved</TITLE></HEAD><BODY> <H1>302 Moved</H1> The document has moved <A HREF="http://ipv4.google.com/sorry/IndexRedirect?continue=http://translate.google.com/translate_a/t?client=a&q=pii&q=S0896-6273&q=j.neuron.2015.05.013&q=elegans+Punctin+Clusters+GABAA+Receptors+via&q=Neuroligin&q=Binding+and+UNC-40%2FDCC+Recruitment&tl=en&sl=auto&amp;q=CGMSBMu9aZ8Y2OjZqwUiGQDxp4NLW_vuiJQA0cSRRi_F4WdisaRqdCQ">here</A>. </BODY></HTML> : S0896-6273(16)30723-1. doi: 10.1016/j.neuron.2016.10.022. [Epub ahead of print]

Timing Rules for Synaptic Plasticity Matched to Behavioral Function.

A Suvrathan, Payne HL, Raymond JL.

http://www.cell.com/neuron/fulltext/S0896-6273(16)30723-1

posted on 12/02/2016 6:06 PM

2016/11/21 Journal Club (Suzuki)

Won-Suk Chung,Philip B. Verghese,Chandrani Chakraborty, Julia Joung, Bradley T. Hyman, Jason D. Ulrich,David M. Holtzman and Ben A. Barres

2016 Sep 6;113(36):10186-91. doi: 10.1073/pnas.1609896113. Epub 2016 Aug 24.

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes,en

posted on 11/18/2016 7:51 PM

2016/11/14 Journal Club (Kono)

Guo et al., (Prof. Regehr’s group) Neuron. 91, 1330–1341

Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex.

posted on 11/12/2016 12:39 PM

2016/11/07 Journal Club (Kakegawa)

Piochon et al. (Prof. Hansel’s group), This paper has been published in PNAS (Early edition)

Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.

posted on 11/06/2016 12:59 PM

10.17.2016 Journal Club (Arai)

Carter BC,ro & year CE
Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction.
Nat Nerusorci, 2016, 19(9), 1218-24, PMID: 27399842

posted on 10/16/2016 2:05 PM