Interview-kun's paper "C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity” was published in Molecular Brain magazine。Cerebellar Purkinje cells form multiple climbing fibers and synapses when young、Unnecessary synapses are pruned during development, except for one climbing fiber。In this paper、climbing fiber：1 Purkinje cell：1Even in the mature cerebellum, which has established the control mode of、By increasing the expression of C1ql1 and Bai3、Purkinje cells create multiple climbing fibers and synapses again、Climbing fibers usually branch in the anterior-posterior direction,、Newly formed synapses originate from branches of climbing fibers that diverge in the medial-lateral direction、They discovered that the presence of electrical activity in climbing fibers and Purkinje cells is necessary for new synapse formation.。Even when the GluD2 glutamate receptor is knocked out after maturation,、It is known that the internal and external branches of multiple climbing fibers form synapses with Purkinje cells.、We also found that this phenomenon is also dependent on C1ql1-Bai3 signaling。

The 158th Brain Club was held on July 14th。This time, Professor Yusaku Iwasaki of Kyoto Prefectural University gave a lecture titled "Direct effects of food-related factors on vagal afferent nerves and their relationship to eating, metabolism, and mental functions."。
It was a semi-closed event that was held onsite only.、A lively discussion took place over time。

The 157th Brain Club was held on June 15th。This time, Professor Imayoshi from Kyoto University.、This is a double feature by Mr. Michikawa.。
・Dr. Itaru Imayoshi (Graduate School of Life Sciences/Institute of Medical Biology, Kyoto University) "Optogenetic analysis of transcription factor expression dynamics that determines the differentiation fate of neural stem cells"
・Dr. Takaaki Michikawa (Institute of Biomedical Sciences, Kyoto University) "Technology and prospects for observing the whole brain"
It was held on-site only.、Enthusiasm for science by both professors led to a lively discussion.。

alreadyGuidanceHowever, Yuzu Lab has been selected for the International Joint Research Acceleration Fund (International Leading Research) ``Multidimensional analysis of memory mechanism – from nm to mesoscale / millisecond to day scale''。Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

postdocs and graduate students、Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience using this framework (IINS) -Short-term and mid-term study abroad at Bordeaux Neurocampus (France)。Interested graduate students and postdocs should visit Grant's website。the poster isInternational Leading Research Poster 230613

At the 156th BrainClub、Dr., Laboratory for Learning and Memory Neural Networks, RIKEN Center for Brain Science. Joshua P. We invited Dr. Johansen (5/10)(Wed) 16:00~17:30）。The title is "Constructing Emotional Representations in the Brain"。sensory input、physiological state of the body、and the cognitive component、Mechanisms controlling memory formation via emotion、He talked about hierarchical and distributed neural network models with recent findings.。The day was held in a hybrid format, and lively discussions took place over time.。

Engineered adhesion molecules drive synapse organization.
In Dylan Hale, Thomas C Südhof, Richard L Huganir
Proc Natl Acad Sci USA 120(3):e2215905120, 2023.

FYI:

Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
--Richard Sando, Milan Lyndie Ho, Xinran Liu, Thomas C. Südhof
J Cell Biol (2022) 221 (2): e202109111.

2022Annual (54th) Naito Memorial Prize for Science Promotionwas awarded to Yuzuzaki。3The presentation ceremony was held at the Industrial Club of Japan on the 16th of the month.。
The award-winning research theme is "Elucidation of the molecular mechanisms that control functional and structural synaptic plasticity"。Thank you to the collaborators, Yuzu Lab's colleagues and OB。

34 days from 6th to 9th of the month、Okinawa Institute of Science and Technology Graduate University (OIST))Meeting after a long time atWorkshop “Nervous System Assembly”It has been made。Poster presentation + Flash talk by Oishi, a graduate student from Yuzaki Lab、Yuzuzaki gave a talk。Blessed with good weather, a lively discussion took place.。                                                                                       Tomi Yoshida of OIST was the organizer。

On November 10, 2018, Keio University launched the World Premier International Research Center Initiative (WPI).)Adopted as a base for、2The kick-off meeting was held on March 3rd.。(Human Biology x MicroBiome x Quantum computing = Bio2Q)As、Focusing on the Microbiome、How human homeostasis is controlled by mucosal epithelium, immunity, nerves, metabolism, etc.、A 10-year project that aims to elucidate using quantum computing with AI。Under Director Honda、Yuzuzaki as the representative of the neural control team、I will also participate as a special assistant to the center director.。

2022JSPS International Joint Research Acceleration Fund (International Leading Research) to “Multidimensional Analysis of Memory Mechanisms”–from nm to mesoscale/millisecond to day scale”.。Bordeaux Neuroscience Institute（Dr. Choquet）、Max Planck Florida Institute（Drs. Yasuda & Fitzpatrick) and Japan.。Represented by Professor Yasunori Hayashi of Kyoto University、At domestic bases of Keio University, NIG, Niigata University, and the University of Tokyo、Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

For postdocs and graduate studentsSupport for short-term and long-term study abroadPlease spread the information so that you can watch it.。AlsoSupport for young researchers when they become independentYou can do it, so please make the most of your chance.。

Yuzaki gave a special lecture on January 21, 2023 at the 11th Neuro Conference Wakayama (Wakayama Medical University Kimiidera Campus)。Invited by Dr. Norimitsu Inoue, Department of Molecular Genetics, a leading expert in complement research。The photo is Professor Murai of the Department of Neurology, International University of Health and Welfare, another special lecturer.。

Core-to-core program symposium “Molecular Physiology of Neuronal Signaling” of the core-to-core program “Research Center for Interdisciplinary Neuronal Signaling” (Doshisha University, Free University of Berlin, IST, Austria, University of Copenhagen), Circuits and Behavior” January 12-14、Yuzu gave an invited talk at Doshisha University in Kyoto。