A reunion party of Keio Physiology Laboratories was held on February 11, 2017. A lecture was also given by Dr. Shibata,ja. See photo.

On February 3 and 6, Dr. Radu Aricescu, a visiting professor from Oxford University, gave two lectures on entitled “Introduction to Modern Structural Biology.”

A review on the delta glutamate receptors (wheels) “A GluD Coming-Of-Age Story (A GluD Coming-of-Age Story)” has been published in Trends in Neuroscience.

Dr. Yuzaki participated and gave a talk at the NUS-Keio Joint Symposium at the National University of Singapore on January 10-11th, 2017. See photos.

Symposium held at the "brain circuit creation of Elucidation and control technology of the formation and operation principle of the forefront 2017- brain circuit of research" is January 20 (Friday) 10:00 30 minutes to Conference Square M (Marunouchi Mitsubishi building 10F) willTodid。This symposium by eight research team that has been adopted in AMED-CREST research expenses。People Ya, which is engaged in the life science and medical research、Planning is that target to the general public who are interested in the mechanism of the brain。Alone with participation tightening is up to 13 days。Click here for detailsUntil。

Otsuka-kun’s thesis paper has been published in J Neurosci. This work was done in collaboration with Dr. Konno (co-first author) in Prof. Watanabe’s laboratory and Dr. Abe in Prof. Sakimura’s laboratory. It was featured as “It has been featured in "This Week in The Journal." .”

 Dr. Yuzaki gave a talk at The 47th NIPS International Symposium “Decoding Synapses,” held at the National Institute of Physiological Science on October 26-28, 2016.

Prof. Yuzaki gave a talk at the OIST mini-symposium/the Core-to-Core program of JSPS, entitled “Nanoscale mechanisms of synaptic functions,” which was held on September 25- 27 at Okinawa. Other speakers include: Larry Trussell, Robert Edwards, Volker Hauck, Nils Brose, If Kavalalı, Ian Forsythe, Peter Jonas, Stephan Sigrist, Reinhard Jahn,Ryuichi Shigemoto, Stephan Hallermann, Alan Marty, Tobias Moser, Ko Matsui, Hiroaki Misonou, Haruhiko Bito, Shinya Kawaguchi, Toshihisa Otsuka, Sumiko Mochida and Tomoyuki Takahashi.

A review for general readers"Science in Keio University School of Medicine"A review of Keiko Matsuda lecturer was published in the。

A new group grantIn the "dynamic control of brain function due to scrap and build" Kakenhi new academic area studies、As kick-off symposium and public research briefing the following will be heldYou。、It ended on a high note。
Date and time：2016On September 8 (wood) 13:00-17:00
Meeting place：The University of Tokyo Faculty of Science, Building No. 1 Koshiba Hall
http://www.u-tokyo.ac.jp/campusmap/cam01_00_25_j.html

For more details, until the Grants-in-Aid for Scientific Research Scientific Research on Innovative Areas "dynamic control of by the scrap-and-build brain function."。
http://www.scrapandbuild.bs.s.u-tokyo.ac.jp/

Oh WC, Wang S, Castillo PE, Kwon HB.
De novo synaptogenesis induced by GABA in the developing mouse cortex.
Science. 2016 Aug 11. [Epub ahead of print] PubMed PMID: 27516412

A new paper, based on collaboration with Dr. Arisesuku's lab at Oxford University, 7has been published in Science on July 15th..。In this research、It is a joint of nerve cells and nerve cells to reveal the structure of the bridge that connects the "synapse"、Nerve cells in conjunction with each other was to elucidate the new mechanisms regulating neural network function。The results of this research”It was featured in the "This week in Science“But it was introduced as "Transmitting signals across the synapse (signal beyond the synapse)."。

In the synapse、Glutamate is released from presynaptic、Excitement to the next nerve cell is transmitted by binding to the glutamate receptor of postsynaptic。Furthermore, from presynaptic、It has been revealed in our laboratory that the group of molecules similar to "complement" of the immune system be released to adjust the synaptic function so far。However、And excitement transmission path through the glutamic acid、How to work and how synaptic regulatory pathways by complement family molecules did not know well。

In small brain circuit、Presynaptic releases complement family molecules referred to as CB El N. 1 (Cbln1)、And then binds to a receptor that neurexins (Nrx) present in the presynaptic。On the other hand、Cbln1 will cause the synapse formed by combining at the same time also to the postsynaptic delta type 2 glutamate receptor (GluD2)。Nozawa-kun, together with Hayashi-san、Nrx-Cbln1-GluD2 the structure of the three-party complex that was the first time Tokiakasa。as a result、Cbln1 not only serve to anchor the presynaptic and postsynaptic as adhesive、By adjusting the working styles itself postsynaptic GluD2 the subtle、It was found to control the happened ease of excitement transmission in the synapse (= memory and learning process)。

Complement family molecules · Nrx · glutamate receptors are also present in various brain regions other than the cerebellum。Therefore、This was revealed、Functional regulation mechanism of glutamate receptors by complement family molecules are expected to be working as well in a variety of neural circuits。