SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.

Araki Y, Rajkovich KE, Gerber EE, Gamache TR, Johnson RC, Tran THN, Liu B, Zhu Q, Hong I, Kirkwood A, Huganir R.

Science. 2024 Mar;383(6686):eadk1291. doi: 10.1126/science.adk1291. Epub 2024 Mar 1.

PMID: 38422154

https://pubmed.ncbi.nlm.nih.gov/38422154/

https://www.science.org/doi/10.1126/science.adk1291

Wang et al. (Dr. Bender group)

Neuron.. 2024 May 1;112(9):1444-1455.e5. doi: 10.1016/j.neuron.2024.01.029. Epub 2024 Feb 26.

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.

Neuron.. 2024 Apr 26:S0896-6273(24)00248-4. doi: 10.1016/j.neuron.2024.04.010.

ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells

Elizabeth P Lackey, Luis Moreira, Aliya Norton, Marie E Hemelt, Tomas Osorno, Tri M Nguyen, Evan From Macosko, Wei-Chung Allen Lee, Court A Hull, Wade G Regehr

PMID: 38692278

A paper co-authored with Jaime de Juan-Sanz of the Sorbonne University in France was published.Published in Cell Reportsit was done。LGI1, like Cbln1, is a synaptogenic molecule that belongs to the class of "extracellular scaffold proteins."。On this occasion、Like Cbln1, LGI1 is also secreted in response to neural activity and promotes synapse formation.、It was also found that it suppresses glutamate release.。Interestingly, Cbln1 is tetanus toxin (TeNT)(VAMP1-3 independent)、Secreted by Syntaxin-4 and SNAP49-dependent SNAREs。In contrast, LGI1 secretion was partially inhibited by TeNT.、Because it does not depend on SNAP29、found to be released by separate SNARE complexes。Yuzaki Lab provided analysis technology for the SNARE complex developed by Ibata。