Department of Neurophysiology, Keio University School of Medicine、has participated in World Brain Week activities 、named "The Recommendation of Brain Studies" 、for high school students who are interested in neuroscience and university research、Not just to know the excitement of brain science,、We hope this event will be an opportunity for you to learn some of the cutting edge of our research at Keio.。
This year、Although access to the university is restricted due to the COVID-19、we are preparing online lectures and virtual lab tours、as well as various projects such as live distribution.。We are looking forward to your participation 。

[Details]Keio University World Brain Week website
https://sites.google.com/view/keioneuroscience
World Brain Week Keio 2020 Poster_A4

Assistant Professor Takeo's paper”GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells”,was published in Neuron.。It was her work while studying abroad at Dr. Liqun Luo Lab at Stanford University.。Congratulations!。

Professor Yuzaki was featured in the digital edition of Asahi Shimbun, in the series of、Keio University and Asahi Shimbun joint project "This piece of research and life".。
It ’s a familiar cell for us、but it's beautiful。Assistant Professor Takeo took this artistic photo。

Rett syndrome is caused by a deletion or decrease in the amount of a nuclear protein called MeCP2 that binds to methylated DNA.、Highly associated with autism spectrum disorders。On the other hand、It is known that even if the amount of MeCP2 protein is increased, mental developmental disorders occur.。However、Until now, it was not well understood how the amount of MeCP2 causes mental illness.。In this study, the amount of MeCP2 regulates the three-dimensional structure of chromatin in nerve cells.、The possibility of changing the expression of various genes was clearly shown using a mouse model.。This work is based on the research conducted by Lecturer Ishida at Zogbhi Lab while studying abroad.、After returning to Japan, it wasPublished in J Neurosci.。

We start reading "Principles of neurobiology 2nd edition"。

Dr. Liqun Luo, a leading figure in the field of neuroscience、wrote this book based on her 20-year's of teaching neurobiology class at Stanford University.。2020The second edition was published in September as a revised edition for the first time in five years.。If you are interested in neurobiology、or English、join our reading circle。

Please e-mail us to attend。10First meeting wil be held at 18:00 on Thursday, 15th of March、.。

※ For further information、please contact Mari*.。

[Place] Held online

[Target] Anyone who wants to learn neurophysiology、or English、and who is interested in reading circle。Individuals of any backgrounds and ages are welcome。

Department of Neurophysiology, Keio University School of Medicine (Yuzaki Lab)  .

*Mari Shiozaki：mari.z6@keio.jp

Formed for the first time in TaiwanTaiwan Society for Neuroscience（TSfN)Tournament is between September 11th and 13th、Held as a hybrid of real conference and web conference。Yuzuzaki as Plenary Talk、「How to Build Synapses: New Mechanisms by Extracellular Scaffolding ProteinsI gave a lecture on。After playing a pre-recorded video lecture at the venue、A lively question-and-answer session was held by connecting Japan and Taiwan online in real time.。

Held from August 31st to September 2nd as a real and web hybrid tournament in Okayama61st Annual Meeting of the Japanese Neurological SocietyIn、"Basic-Clinical" at the Japan Neurological Society (clinical society of neurology) and the Japan Neuroscience Society / Japan Neurochemistry Association、Cross-society symposium：Let's turn our attention to basic science for the treatment of future diseases "。Yuzuzaki says "Recommendation of basic researchI gave a lecture entitled "。

Synapses, which are places for information transmission between nerve cells, are formed by proteins called synapse organizers.、Responsible for precise control of memory and movement。In this study、Based on the structure of synapse organizer proteins、we designed an artificial synapse organizer、and have developed an artificial synapse connector CPTX that can connect excitatory synapses in a wide range of the nervous system.。.、.、When CPTX is administered to the causative region of disease model mice caused by synaptic disruption such as Alzheimer's disease, or spinal cord injury、Reduced synapses recover within a few days、Found to significantly improve the condition。This research was the first successful achievement in the design of artificial synaptic connectors and their application to diseases.。Depending on the design of the artificial synapse connector, it is possible to control various types of neural circuits.、It is expected to lead to basic research and future therapeutic applications for psychiatric and neurological disorders.。For the summary,Click here. 。
This is an international joint research between Japan, the UK and Germany.、Dr. Hiroyuki Sasakura of Aichi Medical University、Professor Tsunesei Takeuchi、Dr. Elegheert, MRC Institute for Molecular Biology, UK、Professor Aricescu、Dr. Song of the German Center for Neurodegenerative Diseases、It is the result of the research with Professor Dityatev and his group.。Also、Assistant Professor Suzuki Kondo、Lecturer Keiko Matsuda、Associate Professor Wataru Kakegawa、Researcher Eriko Miura、Assistant Professor Shintaro Otsuka、 Former medical student Tatsuya Shimada、and many other researchers of our lab have contributed to this work。
For Press releaseClick here. 。

The illustrations were drawn byMr. Mizutani Michi.。

"Dynamic control of brain function by scrap and build" The 5th group meeting was held on the Web for the first time from August 17th to 19th.。This year, Yuzuzaki Lab was in charge of the group meeting.。The team of、Assistant Professors Ishikawa,、Yamazaki,、and Suyama,、with Secretaries Hirayama and Yoshikawa, worked together in preparation for the very first online group meeting and finished successfully.。

8A public panel discussion "Brain Science and Society in 2050" was held on the 2nd of March using Zoom webinar.。It is a future plan, outreach, industry-academia collaboration promotion committee collaboration project of the Japanese Society of Neuroscience.。It was also delivered to YouTube at the same time。Lecturer Ishida participated as a panelist from the laboratory。

The 43rd Japan Neuroscience Congress (Chairman Kitazawa)、It was held from July 29th to August 1st as the first web event in response to the corona disaster.。From the laboratory, Yuzuzaki will be the speaker of the special lecture and symposium (control of brain function and formation of pathological conditions by creative destruction).、Keiko Matsuda as a speaker at the Japan-China Neuroscience Society Joint Symposium、Ishida is a symposium organizer and performer (learning from pathological models)：(Cross-cutting approach to understanding developmental disabilities)。

Nagoya University (Faculty of Medicine on February 19)、20Faculty of Science on the dayAt)、Yuzu Saki gave a lecture。Title is "In the beginning there synapse - synaptic modification mechanism as the foundation of psychiatric and neurological disorders" was。