Small molecules administered to adults、As a new technology that visualizes how and where in the brain it is distributed like a snapshot、We have developed a method for immobilizing small molecules using paraformaldehyde, which is often used in tissue fixation.。by this method、metabotropic glutamate receptor mGlu1、AMPA-type glutamate receptor、Succeeded in visualizing the localization pattern of dopamine receptors after ligand administration。This research was supported by ERATO/CREST.、In collaboration with Nagoya University Seichu Lab、published in Chemit was done。

Science Digest、Human Frontier Science Program (HFSP)is a new publication of。In HFSP-supported research、The most notable scientific achievements are highlighted。Commemorative first issue was published、We are the German Center for Neurodegenerative Diseases(DZNE)of Alexander Dityatev Laboratory、I was informed that the research I conducted with Dr. Radu Aricescu, Oxford University (at that time) has been published.。
HFSP home pagecan be read at。Also、excerpt isfrom hereavailable for download。

Goal 7 of the moonshot research and development project, "Understanding and application of intestinal bacterial action principle for extending healthy life expectancy" was adopted.、A kick-off meeting was held this time。Professor Kenya Honda is the project manager (PM))Is the、Yuzuzaki will participate as PM assistant and team leader of the "gut-brain linkage analysis team"。2022It is a research and development project for 6 years from FY 2019 (up to 9 years until FY 2030).。

Workshop 2022 was held to improve Presentation Skills。

Presentation skills for researchers、In addition to presenting research results and interacting with other researchers,、Returning research results to the general public、It is an essential technology when acquiring research funds。As an active brain science researcher,、Lectures and practical training were given by Professor George Augustine, who has a proven track record in teaching presentation methods.。
Graduate students belonging to Keio University Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, and Graduate School of Science and Engineering、Young researchers participated。

This program is a WPI (Bio2Q)It is scheduled to be held as one of the joint graduate school programs (STaMP) in。

*Click here for Lecture videos→Open to those who belong to Keio University。

※※Lecture and Workshophere (photo)

Japan-U.S. brain. Brain Research Cooperative Program) and Core-to-Core Program supported symposium Development and Plasticity of the Brain was held in Ise-Shima between October 21st and 23rd。This meeting also commemorates the retirement of Professor Nobuhiko Yamamoto.。From the laboratory, Nozawa and Yuzu participated and Nozawa gave an oral presentation in English.。Photos from the symposiumClick here. 。

The 15th ChemBio Lecture hosted by the Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo was held on September 28 at Hongo Campus.、Yuzuzaki<gave a lecture。Another speaker is Professor Makoto Arita (Keio/RIKEN)、Associate Professor Ayumi Ishii (Teikyo University of Science)、Associate Professor Hiroshi Inaba (Tottori University)、It was Professor Hirohisa Omiya (Kyoto University)。

9The 4th event was held in Karuizawa from 19th to 22nd of the month. UK-At the Japan Neuroscience Symposium (sponsored by AMED-MRC)、Ms. Shiozaki, a graduate student, was selected for the best poster award。One presentation from Japan、One topic will be selected from the UK side.、The supplementary prize is the next 5th held in the UK UK-Invitation to oral presentation at Japan Neuroscience Symposium (travel expenses included)。Congratulations!

Ms. DILINA Tuerde、JSPS Special Fellow for Foreigners(PD)Adopted by。Congratulations!。For outstanding young researchers from other countries who have just obtained their Ph.D.、This program provides opportunities to engage in research at Japanese universities and other research institutes.。Only 8 people in all of Japan are employed in biological sciences.。

4th year doctoral student Kazuya Nozawa's dissertationOnline version of Neuron.。For Press releaseClick here. 2022。
by improving Expansion Microscopy (ExM), a high-resolution microscopy technique、Molecules that determine the individuality of synapses in the brain at the nano level (one millionth of a millimeter is one nanometer)：nm) revealed the structure of。

The neural network that underpins the functioning of the brain、Nerve cells are connected to each other by synapses。Various molecules that connect synapses are、Because it is concentrated in a narrow region of about 100 to 1000 nm in the synapse、Its detailed distribution cannot be observed with the resolution of conventional optical microscopes (approximately 200 nm).。there、Nozawa-kun, together with Hayashi-san、We further improved ExM, a technology that expands the specimen itself to about 1000 times its volume.、By optimizing for synaptic observation、For the first time, we succeeded in clarifying the structure and interrelationships of molecular groups that connect excitatory synapses in mouse neural networks at the nano-level.。According to the comment, 、A group of synaptic molecules that bind to neurexin (neurexin ligand)、It was discovered that they accumulate as units of ``nanodomains'' of several tens of nanometers each within synapses.。further、Depending on the type of neurexin present at the presynaptic site、It has been found that the arrangement of nanodomains of post-synaptic synaptic molecules and glutamate receptors is determined。
From the results of this research、The characteristics of synapses that support brain function、It turns out that each specialized synaptic molecule is created by interacting at the nano level.。These molecular groups have been reported to be associated with many psychiatric disorders and neurodevelopmental disorders.、It is expected that the results of this research will lead to an understanding of the pathogenesis of these diseases and the developmental mechanisms of normal neural circuits.。Taku Sogabe, a fifth-year medical student, also contributed greatly to the development of ExM.。

The 151st BrainClub presenters include:、We invited Dr. Takuya Sasaki from the Graduate School of Pharmaceutical Sciences, Tohoku University (Friday, July 15, 2022).、Face-to-face and web hybrid format)。heavy rain、Welcome to Keio University、He gave a lecture titled "Operating Principles of the Hippocampal Circuit Controlling Learning and Memory".。from the hippocampus and related brain regionsin vivoCan be deciphered from analysis results using multi-unit recording、Changes in neural activity during individual learning and memory、He talked about the research results obtained so far.。Also、Please also make a presentation on a new attempt to expand the recording target beyond the brain with the latest knowledge.、Lively discussions took place。

The photo is a commemorative photo taken after the lecture。Sasaki-sensei is in the center back row。Yuzusaki lab has many electrophysiology members。* There is no deep meaning in blurring the background (automatic adjustment of a certain Google smartphone used for trial)。After all, clean up a little ry (conference)

Assistant Professor Takano received the Young Investigator Award from Keio University School of Medicine in the 4th year of Reiwa.。Congratulations!

To understand how neural circuits in the brain work、There is a need for technology that selectively activates glutamate receptors, which are neurotransmitter receptors that control memory and learning.。In this research、While maintaining the original glutamate response ability、Developed a mutant glutamate receptor (metabolized type) activated by an artificial compound。We created mice that actually expressed this artificial glutamate receptor in a specific cell type.、It was shown that the administration of artificial compounds activates metabotropic glutamate receptors in a cell-type selective manner.。It is expected that the understanding of neural circuits will be accelerated by using this new technology "coordination chemogenetics method".。This research was supported by ERATO / CREST, Nagoya University Kiyonaka Lab.、This is a joint research with Kyoto University Hamaji Lab.。Click here for the paper