On this occasion、Conference-kun of the graduate students of this laboratory (D3)And Nozawa-kun (D1)Each but、Japan Society for the Promotion of Science Research Fellow (DC)It became a pre - approved in。Congratulations!。

Yuzusaki reblogged Talk in place the Cold Spring Harbor Asia symposium in Awaji Island。Conference (D3)And Nozawa (D1)Each also、I gave a poster presentation。

Development process of the dendrites of nerve cells are not fully reproduced in the in vitro。For example, juvenile type of neurites but will be trimmed once in the in vivo、This behavior does not know the mechanism may not be observed in in vitro。In this study by observing neurite development process in in vivo by performing intrauterine electroporation、It was revealed that Caveolin-1 controls the development process of dendrites via endocytosis of N- cadherin and L1。It is the job of when the Sendai's has been stayed's with Shikanai to yuzu Saki Research。Paper is here →

Activity-dependent endocytosis of AMPA receptors at postsynaptic sites、which underlies long-term depression (LTD), is thought to mediate certain forms of learning and memory in vivo。However、whether LTD at synaptic levels is causally related to learning and memory at system levels has remained unclear。In thisNeuron paper、using a new optogenetic tool, termed PhotonSABER, which could acutely and reversibly inhibit LTD in a light-dependent manner、we show that LTD at parallel fiber-Purkinje cell synapses、is essential for eye movement-based motor learning in vivo。Dr. Kakegawa, Associate Professor at Keio University、and Dr. Matsuda, Associate Professor at the University of Electro-Communications、performed all experiments with great helps from Dr. Kato, Associate Professor (Tokai Univ.), Dr. Fukasawa, Professor (Fukui Univ) and Dr. Kohda, Professor (St. Mali University School of Medicine)。

TheVideo Abstract has been published in Neuron.。YouTube is here.→。

On this occasion、With the expansion of personnel changes and Research、Newly started the recruitment of Assistant Professor (Adjunct) 1 person。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

As the field
１．Electrophysiological(Brain slices and in vivo) orImagingPeople with a strong background in the field
２．Molecular biology, morphologyPeople with a strong background in the field
I assume any of the。Taking advantage of each of the background、Let's by all means greatly developed from Japan synapse research together。Also I think you'll connect to the future of the step up to learn a new technique in the lab。

If you are interested, please prepare 1) CV with、 2) Research proposal、3) wrote two people Reference destination (name and contact information)、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。

Nozawa-kun, a freshman in the PhD course, has published hisvery first paper in "the Cerebellum."。As there are no antibodies that can be used for immunohistochemical staining、cellular and subcellular localization of Neuroligin-1 has been unclear。Nozawa-kun, together with Hayashi-san、generated a mouse line, in which an HA epitope tag was knocked in the neuroligin-1 gene、Using anti-HA antibody, Nozawa-kun has clarified cellular and sucellular localization of endogenous Neuroligin-1 in the cerebellum。

In good offices All of Keio University School of Medicine and biology classroom, Kajimura Professor、This year also from 2:00 July 14, Saturday, to the laboratory, which was intended for first-year medical school tours have been made。In spite prior to the test、Faculty of Science and Technology, two students + medical students 11 people took part in the eagerly lecture and practice。Some from this will expect to grow up to become a species that aspire to medical research in the future。Photos here（Updated on September2PageThere is also a)。

Since Shimada and Mr. Obata's has been participating in the new labLunch meeting of welcomeThe we。Thank you very much。

It gave a farewell party of Otsuka-kun to study in Anis Contractor Institute of Northwestern University。We prayed all the more and more active。Photos here。

A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse
Keum S, Kim A, Shin JJ, Kim JH, Park J, Shin HS. Neuron. 98:588-601, 2018 (PMID: 29681532)

We ate the cake with everyone to celebrate the secretary of the day。Thank you very much。Photos here

Per the Center for Molecular Neuroscience launched at Stanford University、4月20日にシンポジウムIt has been made。Yuzusaki is I will call on the Nobel Prize scholar Thomas Sudhof、It gave a Keynote address。The Center for Molecular Neuroscience is in a virtual organization、So far long Then came the "Synapse Club" development to eliminate the、We aim to understand the neural circuits and normal and abnormal brain function by understanding the workings of at the molecular level of the synapse。Stanford University School of Medicine、Neuroscience researcher of nearby universities such as UCSF and UCSD not only neurobiology faculty had gathered。Of this timeOther Speaker,,ja,はKang Sheng,,zh-CN,Christian Rosenmund,,en,Lu Chen,,zh-CN,Julia Lalitsschmidt,,en,Li Gan,,zh-CN,He is Dr. Sue Ackerman.,,jaはKang Sheng, Christian Rosenmund, Lu Chen, Julia Lalitsschmidt, Li Gan, Sue Ackerman is Dr.。