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Welcome to Yuzaki Lab
    慶應義塾大学医学部柚崎研(神経生理学)では「神経活動や環境の変化が、どのようにして記憶・学習を引き起こし、どのように神経回路網そのものを変化させるのか」というテーマに沿って研究を行っています
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意欲あふれる方の参加を待っています。これからの基礎科学を担う若手研究者を積極的に育てていきます。
   医学部修士過程はこちら
   医学部博士課程はこちら
   連絡先はこちら
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Journal Club

2017/8/21 Journal Club (Ishida)

Ian Schmitt et al., Nature vol.545, 219 (2017)

Thalamic amplification of cortical connectivity sustains attentional control.

http://www.nature.com/nature/journal/v545/n7653/pdf/nature22073.pdf

posted on 08/18/2017 6:50 PM

2017/7/24 Journal Club (Matsuda)

http://www.sciencedirect.com/science/article/pii/S0896627317305160

posted on 07/24/2017 10:42 AM

2017/7/10 Journal Club (Miura)

Contacts between the endoplasmic reticulum and other membranes in neurons.

PNAS 2017 114 (24) E4859E4867published ahead of print May 30, 2017doi:10.1073/pnas.1701078114

posted on 07/10/2017 10:03 AM

2017/07/03 Journal Club (Ibata)

Activation of cortical somatostatin interneurons prevents the development of neuropathic pain

Nature Neuroscience(2017)doi:10.1038/nn.4595 Published online 26 June 2017

posted on 07/02/2017 6:10 PM

2017/06/12 Journal Club (Nozawa)

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.

Neuron. 2017 May 17;94(4):840-854.e7. doi: 10.1016/j.neuron.2017.04.021.

posted on 06/11/2017 7:44 PM

2017/05/22 Journal Club (Aimi)

Nat Commun. 2017 Apr 4;8:14912. doi: 10.1038/ncomms14912.

Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

posted on 05/21/2017 5:45 PM

2017/05/15 Journal Club (Kakegawa)

Temkin et al. (Dr. Malenka group), Neuron (2017) 94:74-82

The Retromer Supports AMPA Receptor Trafficking During LTP.

posted on 05/14/2017 12:54 PM

2017/5/8 Journal club (Kono)

Assembly of excitatory synapses in the absence of glutamatergic neurotransmission

Richard Sando et al.

Neuron 94, 312-321, April 19, 2017

 

 

 

posted on 05/07/2017 8:56 AM

2017/5/1 Journal Club (Suzuki)

Mark J. Wagner, Tony Hyun Kim, Joan Savall, Mark J. Schnitzer & Liqun Luo

Nature. 2017 Apr 6;544(7648):96-100. doi: 10.1038/nature21726. Epub 2017 Mar 20.

Cerebellar granule cells encode the expectation of reward.

(I will mainly talk about this.)

 

Andrea Giovannucci, Aleksandra Badura, Ben Deverett, Farzaneh Najafi, Talmo D Pereira, Zhenyu Gao, Ilker Ozden, Alexander D Kloth, Eftychios Pnevmatikakis, Liam Paninski, Chris I De Zeeuw, Javier F Medina & Samuel S-H Wang

Nat Neurosci. 2017 May;20(5):727-734. doi: 10.1038/nn.4531. Epub 2017 Mar 20.

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

 

 

posted on 05/01/2017 1:55 AM

2017. 4. 17 Journal club by Arai

Nat Neurosci. 2017 Apr;20(4):529-539.

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation.

Petrovic MM, Viana da Silva S, Clement JP, Vyklicky L, Mulle C, González-González IM, Henley JM.

PMID: 28192396

posted on 04/08/2017 2:11 PM

2017/3/13 Journal Club (Otsuka)

Optogenetic Control of Synaptic Composition and Function

Brooke L. Sinnen, Aaron B. Bowen, Jeffrey S. Forte, Brian G. Hiester, Kevin C. Crosby, Emily S. Gibson, Mark L. Dell’Acqua, and Matthew J. Kennedy
Neuron, 93(3):646-660.

posted on 03/12/2017 6:50 PM

2017/2/20 Journal Club (Yuzaki)

Jin Li, Tamara Casteels, Thomas Frogne, …, Patrick Collombat, Jacob Hecksher-Sørensen, Stefan Kubicek
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Cell 168, 86–100, 2017

posted on 02/20/2017 2:18 AM

journal20170123(ibata)

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses

Xin-Sheng Wu,Sung Hoon Lee,Jiansong Sheng,Zhen Zhang5,,Wei-Dong Zhao,Dongsheng Wang,Yinghui Jin,Patrick Charnay,James M. Ervasti,Ling-Gang Wu
Neuron Volume 92, Issue 5, p1020–1035, 7 December 2016

posted on 01/22/2017 5:48 PM

1/16/2017 Jurnal Club (Motohashi)

Jeffrey D Martell, Masahito Yamagata, Thomas J Deerinck, Sébastien Phan, Carolyn G Kwa, Mark H Ellisman, Joshua R Sanes & Alice Y Ting

A split horseradish peroxidase for the detection of intercellular protein–protein interactions and sensitive visualization of synapses

Nature Biotechnology34,774–780(2016)doi:10.1038/nbt.3563

posted on 01/12/2017 10:51 AM

2016/12/12 Journal Club (Nozawa)

Bo Zhang and Thomas C. Südhof

J Neurosci. 2016 Aug 31;36(35):9070-83. doi: 10.1523/JNEUROSCI.1356-16.2016.

Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.

 

cf. Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses

posted on 12/10/2016 4:48 PM

2016/12/05 Journal Club (Aimi)

Neuron. 2016 Nov 4. pii: S0896-6273(16)30723-1. doi: 10.1016/j.neuron.2016.10.022. [Epub ahead of print]

Timing Rules for Synaptic Plasticity Matched to Behavioral Function.

Suvrathan A, Payne HL, Raymond JL.

http://www.cell.com/neuron/fulltext/S0896-6273(16)30723-1

posted on 12/02/2016 6:06 PM

2016/11/21 Journal Club (Suzuki)

Won-Suk Chung,Philip B. Verghese,Chandrani Chakraborty, Julia Joung, Bradley T. Hyman, Jason D. Ulrich,David M. Holtzman and Ben A. Barres

2016 Sep 6;113(36):10186-91. doi: 10.1073/pnas.1609896113. Epub 2016 Aug 24.

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

posted on 11/18/2016 7:51 PM

2016/11/14 Journal Club (Kono)

Guo et al., (Prof. Regehr’s group) Neuron 91, 1330–1341

Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex.

posted on 11/12/2016 12:39 PM

2016/11/07 Journal Club (Kakegawa)

Piochon et al. (Prof. Hansel’s group), PNAS (Early edition)

Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.

posted on 11/06/2016 12:59 PM

10.17.2016 Journal Club (Arai)

Carter BC & Jahr CE
Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction.
Nat Nerusorci, 2016, 19(9), 1218-24, PMID: 27399842

posted on 10/16/2016 2:05 PM

9/12/2016 Journal Club (Otsuka)

Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD

Cell. 2016 Jul 14;166(2):299-313

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs

 

 

posted on 09/09/2016 9:53 PM

9/5/2016 Journal Club (Takeo)

Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY.

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.

 

 

posted on 09/02/2016 2:16 PM

8/29/2016 Journal Club (Yuzaki)

Oh WC, Lutzu S, Castillo PE, Kwon HB.
De novo synaptogenesis induced by GABA in the developing mouse cortex.
Science. 2016 Aug 11. [Epub ahead of print] PubMed PMID: 27516412

posted on 08/28/2016 6:09 PM

8/8/2016 Journal Club (Suzuki)

Ai-Hui Tang, Haiwen Chen, Tuo P. Li, Sarah R. Metzbower, Harold D. MacGillavr  & Thomas A. Blanpied

Nature(2016)doi:10.1038/nature19058

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

posted on 08/04/2016 8:07 AM

8/1/2016 Journal Club (Miura)

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM

Yan Zhao, Shanshuang Chen, Craig Yoshioka, Isabelle Baconguis & Eric Gouaux

Nature (2016) doi:10.1038/nature18961

 

(参考)

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy

Edward C. Twomey1,2, Maria V. Yelshanskaya1, Robert A. Grassucci1,4, Joachim Frank1,3,4,*, Alexander I. Sobolevsky1,*

Science 01 Jul 2016: Vol. 353, Issue 6294, pp. 83-86

posted on 07/29/2016 12:18 PM

journal,20160725(ibata)

Hemi-fused structure mediates and controls fusion and fission in live cells
Wei-Dong Zhao,
Edaeni Hamid, Wonchul Shin, Peter J. Wen, Evan S. Krystofiak, Seth A. Villarreal, Hsueh-Cheng Chiang, Bechara Kachar & Ling-Gang Wu

posted on 07/24/2016 5:26 PM

7/11/2016 Journal Club (Nozawa)

Feng Gao, Xiao Z Shen, Feng Jiang, Yongqiang Wu, Chunyu Han.

DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

Nature Biotechnology 2016 May 2.

doi: 10.1038/nbt.3547. [Epub ahead of print]

 

posted on 07/08/2016 6:55 PM

7/4/2016 Journal Club (Aimi)

Lrp4 in astrocytes modulates glutamatergic transmission.

Nature Neuroscience(2016)doi:10.1038/nn.4326

Sun XD, Li L, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, Mei L.

Published online 13 June 2016

http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4326.html

posted on 07/01/2016 8:53 PM

6/20/2016 Journal Club (Kono)

Weilinger et al., Nat Neurosci (2016) 19, 432

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity.

posted on 06/17/2016 8:24 PM

6/9/2016 Journal Club (Arai)

Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation.

Boyce et al., Science  13 May 2016: Vol. 352, Issue 6287, pp. 812-816

posted on 06/05/2016 9:11 PM

5/30/2016 Journal Club (Otsuka)

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Dheeraj S. Roy , Autumn Arons , teryn I. Mitchell , Michele Pignatelli , tomás J. Ryan  & Susumu tonegawa

Nature531,508–512(24 March 2016)doi:10.1038/nature17172

posted on 05/28/2016 12:25 AM

5/16/2016 Journal Club (Takeo)

Lisa Traunmüller, Andrea M. Gomez, Thi-Minh Nguyen, Peter Scheiffele

Control of neuronal synapse specification by a highly dedicated alternative splicing program

Science 12 May 2016 (published online ahead of print)

DOI: 10.1126/science.aaf2397

posted on 05/15/2016 12:16 PM

5/9/2016 Journal Club (Takeo)

posted on 05/06/2016 7:38 PM

5/2/2016 Journal Club (Yuzaki)

Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
Nature 2016 Apr 27. doi:10.1038/nature17664. [Epub ahead of print] あまり面白くなかったですが・・・。

 

posted on 05/01/2016 10:28 PM

160411 Journal Club (Matsuda)

http://www.nature.com/nature/journal/v530/n7591/full/nature16971.html#ref10

posted on 04/09/2016 6:24 PM

2016.04.04 Jurnal Club (motohashi)

BIOLOGY OF REPRODUCTION (2016) 94(1):21, 1–8   DOI 10.1095/biolreprod.115.134023

High-Yield Superovulation in Adult Mice by Anti-Inhibin Serum Treatment Combined
with Estrous Cycle Synchronization

Ayumi Hasegawa, Keiji Mochida, Hiroki Inoue, Yoshihiro Noda, Tamao Endo,Gen Watanabe, and Atsuo Ogura

 

posted on 03/30/2016 7:21 PM

2016.3.28 JC (Suzuki)

Sekar, A. et al. Nature 530, 177–183 (2016).

Schizophrenia risk from complex variation of complement component 4

 

posted on 03/26/2016 2:45 PM

journal20160314(ibata)

Nature Neuroscience Published online 07 March 2016

Genetically targeted magnetic control of the nervous system

Michael A Wheeler,    Cody J Smith,    Matteo Ottolini,    Bryan S Barker,    Aarti M Purohit,    Ryan M Grippo,    Ronald P Gaykema,    Anthony J Spano,    Mark P Beenhakker,    Sarah Kucenas,    Manoj K Patel,    Christopher D Deppmann    & Ali D Güler

posted on 03/11/2016 4:26 PM

2016.3.7 Journal Club (Kakegawa)

Gao et al. (Dr. De Zeeuw group), Neuron 2016, 89(3):645-57.

Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning.

posted on 03/04/2016 1:29 PM

2016.2.15 Journal Club (by Arai)

Ten Brinke MM, Boele HJ, Spanke JK, Potters JW, Kornysheva K, Wulff P, IJpelaar AC, Koekkoek SK, De Zeeuw CI.

Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice.

Cell Rep. 2015 Dec 1;13(9):1977-88. doi: 10.1016/j.celrep.2015.10.057. Epub 2015 Nov 19.  PMID: 26655909

posted on 02/12/2016 7:52 PM

2016 1/25 Journal Club (Takeo)

Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo.

Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JD.

http://www.sciencedirect.com/science/article/pii/S1534580715007960

posted on 01/22/2016 5:58 PM

2015.12.14 Journal Club (Otsuka)

Origins of choice-related activity in mouse somatosensory cortex

Connor et al., Nat Neurosci., 2015

posted on 12/14/2015 1:13 AM

20151207 Journal Club (Yuzaki)

Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing
Kole MJ, Qian J, Waase MP, Klassen TL, Chen TT, Augustine GJ, Noebels JL.
J Neurosci. 2015 Aug 12;35(32):11433-44. doi: 10.1523/JNEUROSCI.1346-15.2015.

posted on 12/07/2015 1:41 AM

20151116 Journal Club (松田)

Rost BR, Schneider F, Grauel MK, Wozny C, G Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C.
Optogenetic acidification of synaptic vesicles and lysosomes.
Nat Neurosci. 2015 Nov 9. doi: 10.1038/nn.4161. [Epub ahead of print] PubMed PMID: 26551543.

posted on 11/13/2015 6:00 PM

20151109 Journal Club(三浦)

Glia-derived neurons are required for sex-specific learning in C. elegans

Michele Sammut1 , Steven J. Cook2 , Ken C. Q. Nguyen2 , Terry Felton1 , David H. Hall2 , Scott W. Emmons2,3, Richard J. Poole1 * & Arantza Barrios1 *

Nature, 15 October (Vol. 526), 2015

posted on 11/06/2015 3:13 PM

20151102 Journal Club (幸田)

Nature. 2015 Oct 29;526(7575):653-9. doi: 10.1038/nature15389. Epub 2015 Oct 5.

Projections from neocortex mediate top-down control of memory retrieval.

Rajasethupathy P, Sankaran S, Marshel JH, Kim CK, Ferenczi E, Lee SY, Berndt A, Ramakrishnan C, Jaffe A, Lo M, Liston C, Deisseroth K

http://www.nature.com/nature/journal/v526/n7575/pdf/nature15389.pdf

posted on 11/02/2015 10:00 AM

journal 20151019ibata

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals
The Journal of Neuroscience, 7 October 2015, 35(40): 13629-13647

Christian Neupert, Romy Schneider,Oliver Klatt,Carsten Reissner, Daniele Repetto, Barbara Biermann, Katharina Niesmann, Markus Missler, and Martin Heine

posted on 10/17/2015 6:03 PM

2015.9.7 JC (Suzuki)

Cell, Volume 162, Issue 4, 13 August 2015, Pages 808–822 doi:10.1016/j.cell.2015.07.018

Wen-Jie Bian, Wan-Ying Miao, Shun-Ji He, Zilong Qiu, Xiang Yu

Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

posted on 09/02/2015 2:21 PM

journal club 2015.08.31 (Kono)

Luo et al. (Sudhof group), Journal of Neuroscience (2015) 33, 11024-11033

Synaptotagmin-7 Is Essential for Ca2-Triggered Delayed Asynchronous Release But Not for Ca2-Dependent Vesicle Priming in Retinal Ribbon Synapses.

 

 

posted on 08/28/2015 11:48 PM

2015.8.24 Journal Club (Kakegawa)

Murphy-Royal et al. (Stéphane Oliet group), Nature Neuroscience (2015) 18, 219-226.

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission.

posted on 08/19/2015 11:13 AM

2015.8.17 Journal Club (by Arai)

He Q, Duguid I, Clark B, Panzanelli P, Patel B, Thomas P, Fritschy JM, Smart TG.

Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.

Nat Commun. 2015 Jul 16;6:7364. doi: 10.1038/ncomms8364.  PMID: 26179122

posted on 08/14/2015 5:04 PM

2015.7.13(竹尾)

Chen JL, Margolis DJ, Stankov A, Sumanovski LT, Schneider BL, Helmchen F.

Nat Neurosci. 2015 Jun 22. doi: 10.1038/nn.4046. [Epub ahead of print]

Pathwayspecific reorganization of projection neurons in somatosensory cortex during learning.

PMID:26098757

posted on 07/13/2015 10:10 AM

2015.07.06 Journal club (Otsuka)

Neuron. 2015 Jun 3;86(5):1277-89. doi: 10.1016/j.neuron.2015.05.027.

Parvalbumin Interneurons of Hippocampus Tune Population Activity at Theta Frequency

posted on 07/06/2015 11:12 AM

20150629 Journal Club (幸田)

Nature 522: 335-339, 2015 (PMID;26085274)

Ramirez, et al.

Activating positive memory engrams suppresses depression-like behaviour.

http://www.nature.com/nature/journal/v522/n7556/pdf/nature14514.pdf

 

 

posted on 06/29/2015 9:38 AM

2015.6.8 Journal Club (Matsuda)

Neuron. 2015 May 28. pii: S0896-6273(15)00420-1. doi: 10.1016/j.neuron.2015.05.013. [Epub ahead of print]

 

posted on 06/07/2015 9:46 PM

2015.6.1 Jurnal club (Motohashi)

Dan Zhu et al.   J Clin Invest. 2015 Apr;125(4):1497-508.

BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.

posted on 06/01/2015 10:28 AM

2015.5.25 Journal Club (Suzuki)

Nature 520, 499–504 (23 April 2015)  doi:10.1038/nature14402

Bianca J. Marlin, Mariela Mitre, James A. D’amour, Moses V. Chao & Robert C. Froemke

Oxytocin enables maternal behaviour by balancing cortical inhibition

posted on 05/25/2015 12:11 AM

20150518 journal (ibata)

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

Cell Volume 161, Issue 4, 7 May 2015, Pages 803–816

posted on 05/17/2015 8:16 PM

2015.05.11 journal club (Kono)

A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores

posted on 05/09/2015 7:01 PM

Journal Club on 2015. 04. 20 (by ARAI)

Neuron (2015) 86, 1-12

“Circuit Mechanisms Underlying Motor Memory Formation in the Cerebellum.”

Lee et al.

posted on 04/19/2015 3:01 PM

2015.4.13 Journal Club (Kakegawa)

Deidda et al., Nature Medicine 21, 318-326 (2015)

Reversing excitatory GABAA-R signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.

posted on 04/12/2015 9:18 PM

2015年3月31日 JC Takeo

Nat Commun. 2015 Mar 9;6:6464. doi: 10.1038/ncomms7464.

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo

Wilms CD, Häusser M.

posted on 03/31/2015 9:46 AM

2015.3.17 Journal club Otsuka

Huganir et al., Nature Neuroscience, 2015

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo

posted on 03/14/2015 5:42 PM

2015.03.02 Journal Club(Ida)

BDNF-dependent plasticity induced by peripheral inflammation in the primary sensory and the cingulate cortex triggers cold allodynia and reveals a major role for endogenous BDNF as a tuner of the affective aspect of pain

http://www.ncbi.nlm.nih.gov/pubmed/25355226

http://www.jneurosci.org/content/34/44/14739.full.pdf+html

よろしくおねがいいたします

 

posted on 03/02/2015 10:57 AM

2015年2月10日 Journal Club (Miura)

Three-dimensional head-direction coding in the bat brain
Finkelstein A, Derdikman D, Rubin A, Foerster JN, Las L, Ulanovsky N.
Nature. 2015 Jan 8;517(7533):159-64

posted on 02/06/2015 5:20 PM

2015年2月3日 松田

http://www.sciencedirect.com/science/article/pii/S0896627314011027

posted on 02/03/2015 9:58 AM

2015. 1. 19. Journal Club (Kohda)

The Journal of Neuroscience 34(45): 14845-14853, 2014

Cerebellar-Dependent Expression of Motor Learning during Eyeblink Conditioning in Head-Fixed Mice

Shane A. Heiney, Margot P. Wohl, Selmaan N. Chettih, Luis I. Ruffolo, and Javier F. Medina

http://www.jneurosci.org/content/34/45/14845.full.pdf+html

posted on 01/19/2015 10:10 AM

2014.12.8 Journal Club (Suzuki)

Nature Communications 5, Article number:5586 doi:10.1038/ncomms6586, 24 November 2014

Piochon et al.,

Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

posted on 12/08/2014 1:34 AM

2014.12.1 Journal Club (Kono)

The Journal of Neuroscience, September 10, 2014 • 34(37):12289 –12303

Liu et al.,

The Active Zone Protein Family ELKS Supports Ca2+ Influx at Nerve Terminals of Inhibitory Hippocampal Neurons

posted on 12/01/2014 12:18 AM

20141117JournalClub(ibata)

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

posted on 11/16/2014 5:48 PM

2014.11.10 Journal Club (Tim)

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

posted on 11/09/2014 3:19 PM

2014.9.22 Journal Club (Kakegawa)

Jo et al. (C Justin Lee’s group), Nature Medicine (2014) 20: 886-896

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease.

posted on 09/20/2014 4:25 PM

2014.9.8 Journal Club (Yuzaki)

Samuel S.-H. Wang, Alexander D. Kloth, Aleksandra Badura
The Cerebellum, Sensitive Periods, and Autism
Neuron 83, 518-532, August 6, 2014

posted on 09/07/2014 11:35 PM

14/9/1 大塚

Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex

Namba et al.,2014, Cell

posted on 09/01/2014 10:21 AM

8/25 Journal Club (松田)

http://www.sciencedirect.com/science/article/pii/S2211124714005816

posted on 08/22/2014 11:34 AM

2014.8.4 竹尾

http://www.sciencemag.org/content/344/6188/1178.full.pdf

posted on 08/04/2014 9:49 AM

2014.7.28. (Kawauchi)

PNAS (2014) Vol.111 (6) 2337-2342.

TBC1D24 regulates neuronal migration and maturation through modulation of the Arf6-dependent pathway

http://www.pnas.org/content/111/6/2337.full

 

posted on 07/28/2014 9:22 AM

2014/07/14 Ida

http://www.nature.com/nmeth/journal/v10/n9/full/nmeth.2559.html#access

Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE.

よろしくお願いいたします。

posted on 07/13/2014 4:28 PM

2014/07/07 幸田

http://www.nature.com/nature/journal/v508/n7494/pdf/nature13028.pdf

posted on 07/07/2014 11:04 AM

2014年6月30日 松田恵

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain
Science 30 May 2014:Vol. 344 no. 6187 pp. 1020-1023
http://www.sciencemag.org/content/344/6187/1020.full

posted on 06/29/2014 7:55 PM

Journal 6/23 ibata

Non-Cell-Autonomous Mechanism of Activity-Dependent Neurotransmitter Switching
Alicia Guemez-Gamboa, Lin Xu, Da Meng, Nicholas C. Spitzer
http://www.cell.com/neuron/pdf/S0896-6273(14)00344-4.pdf

posted on 06/22/2014 2:25 AM

2014.6.16 JC Suzuki

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission
Nature (2014) doi:10.1038/nature13248

posted on 06/16/2014 4:15 AM

June 2, 2014 Journal Club (Tim)

Amygdala interneuron subtypes control fear learning through disinhibition
Nature 509, 453–458 (22 May 2014)
http://www.nature.com/nature/journal/v509/n7501/full/nature13258.html

posted on 06/02/2014 11:09 AM

2014/5/26 本橋

olfactory exposure to males, including men, causes stress and related analgesia in rodents

Nature Methods (2014) doi:10.1038/nmeth.2935

posted on 05/25/2014 3:53 PM

5月19日 Journal Club (松田)

http://ac.els-cdn.com/S0896627314002578/1-s2.0-S0896627314002578-main.pdf?_tid=ca72915a-dcce-11e3-9225-00000aab0f01&acdnat=1400226827_1b5cc780f51dc6d7562e6218ae003284

posted on 05/16/2014 4:51 PM

May 12, 2014 (Yuzaki)

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis
Cell Volume 157, Issue 3, p726–739, 24 April 2014

posted on 05/11/2014 9:00 PM

2014/4/21 大塚

A Map of LTP-Related Synaptic Changes in Dorsal Hippocampus Following Unsupervised Learning

posted on 04/20/2014 6:56 PM

2014/04/07 (掛川)

Lee et al. (Prof. Carla J. Shatz group), Nature (2014) AOP

Synapse elimination and learning rules co-regulated by MHC class I H2-Db.

http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature13154.pdf

posted on 04/05/2014 2:21 PM

2014年3月31日 竹尾

http://www.sciencemag.org/content/343/6173/857.full.pdf

posted on 03/31/2014 9:59 AM

2014.03.17 (kawauchi)

 

Journal of Neuroscience (2013) Vol. 33 (46), 18149-18160

N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration

 

http://www.jneurosci.org/content/33/46/18149.long

posted on 03/16/2014 10:12 PM

20140310 journal club 井田

http://onlinelibrary.wiley.com/doi/10.1002/ana.23892/pdf

Cell age specific Vulnerability of Neurons to Anesthetic Toxicity

よろしくお願いいたします

posted on 03/10/2014 10:24 AM

2月10日  幸田

http://www.sciencemag.org/content/early/2014/01/22/science.1244634.full.pdf

posted on 02/10/2014 10:06 AM

2013/2/3 松田(恵)

http://www.sciencedirect.com/science/article/pii/S0896627313005527

posted on 02/01/2014 4:40 PM

2014/01/20 Takkahashi

http://www.pnas.org/content/111/1/E188.full.pdf+html?with-ds=yes

posted on 01/20/2014 5:06 AM

2013年12月2日(井端)

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission
http://www.sciencedirect.com/science/article/pii/S0896627313007587/pdfft?md5=b33ae3281fa93fbac9d027e0ba6f897b&pid=1-s2.0-S0896627313007587-main.pdf

posted on 11/29/2013 6:01 PM

2013年11月11日(Tim)

GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
VOLUME 16 | NUMBER 10 | OCTOBER 2013 Nature Neuroscience
http://www.nature.com/neuro/journal/v16/n10/pdf/nn.3491.pdf

posted on 11/11/2013 9:48 AM

2013年10月21日(鈴木)

http://www.nature.com/neuro/journal/v16/n10/full/nn.3516.html

posted on 10/19/2013 8:59 PM

2013年9月9日(三浦)

 

An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells.

Neuron 79, 680-695, August 21, 2013

 

posted on 09/05/2013 3:46 PM

2013年9月2日(松田)

http://www.nature.com/nature/journal/v500/n7463/fp/nature12466_ja.html

posted on 08/30/2013 9:33 AM

2013年8月19日 大塚

Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Daejong Jeon, Sangwoo Kim, Mattu Chetana, Daewoong Jo, H Earl Ruley, Shih-Yao Lin, Dania Rabah, Jean-Pierre Kinet & Hee-Sup Shin
Nature neuro sci., 2010

posted on 08/18/2013 4:42 PM

2013年8月5日 (竹尾)

http://www.jneurosci.org/content/33/29/11916.full.pdf+html

posted on 08/02/2013 3:30 PM

2013年7月22日 岩室

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4027-32. doi: 10.1073/pnas.1219454110. Epub 2013 Feb 19.

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.

Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R.

posted on 07/19/2013 1:52 PM

2013.7.8. (Kawauchi)

 

Nature Neuroscience (2013) 16, 416-425.

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism

 

http://www.nature.com/neuro/journal/v16/n4/full/nn.3336.html

posted on 07/08/2013 10:00 AM

2013/07/01 (掛川)

Michalski et al., Neuron 78, 855-868 (2013)

Robo3-Driven Axon Midline Crossing Contributes Functional Maturation of a Large Commissural Synapse.

http://ac.els-cdn.com/S0896627313003085/1-s2.0-S0896627313003085-main.pdf?_tid=b8a064e6-e17c-11e2-8e0d-00000aab0f27&acdnat=1372593836_86d332f9ae072649f3d90141019c0892

posted on 06/30/2013 9:05 PM

2013/06/24 Journal club

2013/06/24 journal club 井田

http://www.jneurosci.org/content/33/17/7184.full.pdf+html

 

posted on 06/21/2013 11:07 AM

2013/06/17 幸田

http://www.jneurosci.org/content/33/23/9794.long

これだけでは、短い(?)ので・・・

よろしければ、

http://www.jneurosci.org/content/33/19/8301.long

も・・・

 

posted on 06/17/2013 10:11 AM

2013. 06. 10 JC takahashi

http://www.nature.com/neuro/journal/v16/n6/pdf/nn.3387.pdf

posted on 06/09/2013 2:00 PM

2013年6月3日 Journal Club (松田恵)

http://www.sciencedirect.com/science/article/pii/S0092867413001475

posted on 06/03/2013 9:15 AM

松田5/20 Journal

http://jcb.rupress.org/content/201/2/293.long

posted on 05/16/2013 11:55 AM

5/13 journal

5/13 ibata

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

http://www.nature.com/neuro/journal/v16/n5/full/nn.3356.html

posted on 05/10/2013 2:01 PM

大塚 4/21/2013

Jocelyn F Krey, Sergiu P Paşca, Aleksandr Shcheglovitov, Masayuki Yazawa, Rachel Schwemberger, Randall Rasmusson & Ricardo E Dolmetsch
T imothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

Nat Neurosci. 2013 Feb;16(2):201-9.

posted on 04/21/2013 5:30 PM

柚崎 4/8/2013

Condon KH, Ho J, Robinson CG, Hanus C, Ehlers MD.
The Angelman Syndrome Protein Ube3a/E6AP Is Required for Golgi Acidification and Surface Protein
Sialylation.
J Neurosci. 2013 Feb 27;33(9):3799-814.

posted on 04/07/2013 7:34 PM

2013年4月1日 (林)

http://www.sciencedirect.com/science/article/pii/S089662731200267X#

posted on 03/30/2013 4:25 PM

2013年3月11日 岩室

Neuron. 2012 Nov 21;76(4):762-75. doi: 10.1016/j.neuron.2012.10.013.
DeNardo LA, de Wit J, Otto-Hitt S, Ghosh A.

posted on 03/06/2013 9:50 AM

2013/3/4 本橋

Effects of Climbing Fiber Driven Inhibition on Purkinje Neuron Spiking

The Journal of Neuroscience, December 12, 2012 32(50):17988–17997

Paul J. Mathews, Ka Hung Lee, Zechun Peng, Carolyn R. Houser, and Thomas S. Otis

 

posted on 03/04/2013 12:47 AM

2013/02/04 (掛川)

Granger et al., Nature (Article) 493, 495-500 (2013)

LTP requires a reserve pool of glutamate receptors independent of subunit type.

http://www.nature.com/nature/journal/v493/n7433/pdf/nature11775.pdf

posted on 02/04/2013 10:08 AM

2013/01/21(川内)

POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration

Yang T, Sun Y, Zhang F, Zhu Y, Shi L, Li H, Xu Z.

Cell Rep. (2012) Vol.2 (3) 640-651.

http://dx.doi.org/10.1016/j.celrep.2012.08.007

posted on 01/18/2013 5:51 PM

12/10/12 幸田

Raf Kinase Inhibitory Protein is Required for Cerebellar Long-Term Synaptic Depression by Mediating PKC-Dependent MAPK Activation.

Yamamoto Y, Lee D, Kim Y, Lee B, Seo C, Kawasaki H, Kuroda S, Tanaka-Yamamoto K. JNS 2012
http://www.jneurosci.org/content/32/41/14254.full.pdf

posted on 12/10/2012 9:53 AM

2012/12/03 高橋

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

Nature. 2012 Aug 30;488(7413):647-51

http://www.nature.com/nature/journal/v488/n7413/pdf/nature11310.pdf

よろしくお願いします。

posted on 12/01/2012 8:18 PM

2012年11月19日 松田(恵)

http://www.sciencedirect.com/science/article/pii/S0896627312006551

posted on 11/19/2012 10:34 AM

2012年11月5日(三浦)

http://www.pnas.org.kras2.lib.keio.ac.jp:2048/content/109/41/16737.full.pdf+html

Dynamics of the leading process, nucleus, and Golgi apparatus of migrating cortical interneurons in living mouse embryos

Yanagida M, Miyoshi R, Toyokuni R, Zhu Y, Murakami F.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16737-42.

posted on 11/04/2012 12:31 AM

10/29 journal(ibata)

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer’s disease
http://www.nature.com/neuro/journal/v15/n10/full/nn.3199.html

posted on 10/25/2012 10:03 PM

2012/10/15 (松田)

http://www.sciencedirect.com/science/article/pii/S0896627312006563

posted on 10/12/2012 11:10 AM

2012/9/3 (大塚)

2012/9/3 (大塚)

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

Alice M Stamatakis1 & Garret D Stuber1,2

Nature neuroscience. 24 June 2012; doi:10.1038/nn.3145

posted on 09/01/2012 6:38 PM

8/27/2012 (Yuzaki)

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.

Lefebvre JL, Kostadinov D, Chen WV, Maniatis T, Sanes JR.

Nature. 2012 Aug 22;488(7412):517-21.

 

posted on 08/26/2012 7:06 PM

2012年7月23日 (岩室)

posted on 07/20/2012 11:17 AM

2012年7月9日 (本橋)

Reduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin
Toru Takeo and Naomi Nakagata

BIOLOGY OF REPRODUCTION 85, 1066–1072 (2011)

posted on 07/09/2012 10:31 AM

2012/07/02 (林)

http://www.pnas.org/content/109/22/8740.full.pdf+html?with-ds=yes

PNAS 2012

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease.

 

posted on 07/02/2012 10:26 AM

2012/06/18 (掛川)

Allen et al., Nature (2012) doi:10.1038/nature11059

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.

http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature11059.pdf

posted on 06/16/2012 10:41 PM

2012/06/11  幸田

http://www.nature.com/nature/journal/vnfv/ncurrent/pdf/nature11028.pdf

posted on 06/11/2012 10:39 AM

2012年6月4日 高橋

GABAergic Inhibition Regulates Developmental Synapse Elimination in the Cerebellum

Neuron. 2012 Apr 26;74(2):384-96.

posted on 06/01/2012 3:32 PM

2012.5.14(ibata)

Cell Reports
Visualization of Subunit-Specific Delivery of Glutamate Receptors to Postsynaptic Membrane during Hippocampal Long-Term Potentiation

Hiromitsu Tanaka, Tomoo Hirano

http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=280959&_user=1730089&_pii=S2211124712000472&_check=y&_origin=article&_zone=toolbar&_coverDate=19-Apr-2012&view=c&originContentFamily=serial&wchp=dGLbVBA-zSkWb&md5=2297a9e6a191ebdac8a825170e4d922c/1-s2.0-S2211124712000472-main.pdf

posted on 05/11/2012 5:00 PM

2012年4月16日(三浦)

Pinceau Organization in the Cerebellum Requires Distinct Functions of Neurofascin in Pukinje and Basket Neurons during Postnatal Development

The Journal of Neuriscience, vol. 32:4724-4742, 2012

posted on 04/12/2012 10:06 PM

松田(4月9日)

http://www.nature.com/neuro/journal/v15/n4/pdf/nn.3053.pdf

posted on 04/06/2012 9:08 AM

2012年4月2日(大塚)

Jun B Ding, Won-Jong Oh, Bernardo L Sabatini & Chenghua Gu

Semaphorin 3E–Plexin-D1 signaling controls   pathway-specific synapse formation in the striatum

http://www.nature.com/neuro/journal/v15/n2/full/nn.3003.html

posted on 04/02/2012 11:30 AM

2012年3月26日(柚崎)

Shinji Miyata, Yukio Komatsu, Yumiko Yoshimura, Choji Taya & Hiroshi Kitagawa

Persistent cortical plasticity by upregulation of chondroitin 6-sulfation

Nature Neuroscience 15, 414–422 (2012) doi:10.1038/nn.3023

posted on 03/25/2012 6:04 PM

2012年3月12日(岩室)

Hippocampus. 2012 Jan 23.
Selective facilitation of LTP in the ventral hippocampus by calcium stores.
 
 

posted on 03/07/2012 4:03 PM

2012年3月5日 (林)

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo.

Fu M, Yu X, Lu J, Zuo Y. Nature 2012

http://www.nature.com/nature/journal/v483/n7387/pdf/nature10844.pdf

posted on 03/05/2012 10:40 AM

2012年2月13日 (本橋)

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

Nature Neuroscience Advance online publication

http://www.nature.com/neuro/journal/vaop/ncurrent/pdf/nn.3020.pdf

posted on 02/10/2012 6:21 PM

2012/02/06 (掛川)

Marin-Burgin et al., Science (in press)

Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons.

http://www.sciencemag.org/content/early/2012/01/25/science.1214956.full.pdf

posted on 02/06/2012 10:27 AM

1/16/12  幸田

http://www.sciencemag.org/content/334/6061/1415.full.pdf

posted on 01/16/2012 10:26 AM

2011.12.5 野村

http://www.jneurosci.org/content/31/24/8862.full.pdf+html

posted on 12/03/2011 4:42 PM

2011年11月21日 松田(恵)

遅くなりまして申し訳ありません。
http://www.nature.com/neuro/journal/v14/n7/full/nn.2837.html
プリントしたものをセミナー室に置いてあります。

posted on 11/21/2011 10:27 AM

10月31日(松田)

http://www.nature.com/neuro/journal/v14/n10/full/nn.2907.html

posted on 10/28/2011 12:31 PM

2011年10月17日 (三浦)

Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.

PNAS 2011, vol.108, E265-274

http://www.pnas.org/content/108/27/E265.full.pdf+html?sid=fed19acd-e7b4-4a7f-af6f-d4d73458da65

 

posted on 10/17/2011 10:34 AM

2011年8月29日 (本橋)

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13764-9

http://www.pnas.org.kras2.lib.keio.ac.jp:2048/content/108/33/13764.full.pdf+html

posted on 08/27/2011 12:50 PM

http://www.nature.com/neuro/journal/v14/n8/pdf/nn.2844.pdf

Zinc alleviates pain through high- afinity binding to the NMDA receptor NR2A subunit.

 8/22  井田

posted on 08/22/2011 10:46 AM

2011年8月8日 (岩室)

Fidzinski P, Wawra M, Dugladze T, Gloveli T, Heinemann U, Behr J.
Low-Frequency Stimulation of the Temporoammonic Pathway Induces Heterosynaptic Disinhibition in the Subiculum
Hippocampus. 2011 Jul;21(7):733-43. doi: 10.1002/hipo.20791. Epub 2010 Apr 13.
 
 

posted on 08/01/2011 4:45 PM

2011年8月1日(大塚)

PLoS ONE  April 2011

Neurodevelopmental Disruption of Cortico-Striatal
Function Caused by Degeneration of Habenula Neurons

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019450

posted on 08/01/2011 11:34 AM

2011年7月11日 (林)

Nature

Xiaowei Chen, Ulrich Leischner, Nathalie L. Rochefort, Israel Nelken & Arthur Konnerth

Functional mapping of single spines in cortical neurons in vivo.

http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature10193.pdf

posted on 07/10/2011 5:20 PM

2011/06/27 (掛川)

Okamoto et al., Journal  of Neuroscience (2011) 31, 8958-8966.

Role of cerebellar cortical protein synthesis in transfer of memory trace of cerebellum-dependent motor learning.

http://www.jneurosci.org/content/31/24/8958.full



posted on 06/25/2011 10:34 PM

2011年6月21日  幸田

Nature
Hyung-Bae Kwon1 & Bernardo L. Sabatini
Glutamate induces de novo growth of functional spines in developing cortex

http://www.nature.com/nature/journal/v474/n7349/full/nature09986.html

posted on 06/20/2011 10:34 AM

2011年6月6日(野村)

Probing TARP Modulation of AMPA Receptor Conductance with Polyamine Toxins.

Jackson AC, Milstein AD, Soto D, Farrant M, Cull-Candy SG, Nicoll RA.

J Neurosci. 2011 May 18;31(20):7511-20.

posted on 06/06/2011 7:49 PM

2011年5月16日(松田恵)

Temporally matched subpopulations of selectively interconnected principal neurons in the hippocampus

http://www.nature.com/neuro/journal/v14/n4/full/nn.2768.html

posted on 05/16/2011 10:16 AM

2011年5月9日(井端)

Molecular Motor KIF17 Is Fundamental for Memory and Learning via Differential Support of Synaptic NR2A/2B Levels.

Neuron. 2011 Apr 28;70(2):310-25.

http://www.cell.com/neuron/retrieve/pii/S0896627311002066

posted on 05/06/2011 3:29 PM

2011年5月2日 (松田)

The AAA+ ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior
Cell 145: 284-299, 2011

posted on 04/27/2011 2:50 PM

2011年4月17日 (柚崎)

The neural substrates of rapid-onset Dystonia-Parkinsonism
Nature Neuroscience 14.357–365 (2011)
http://www.nature.com/neuro/journal/v14/n3/abs/nn.2753.html

posted on 04/17/2011 6:37 PM

2011年4月11日 (本橋)

β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment

Neuron. 2011 Mar 24;69(6):1132-46.

http://download.cell.com/neuron/pdf/PIIS0896627311001565.pdf?intermediate=true

posted on 04/11/2011 10:10 PM